Protein Alignment HLH3B and Atoh8

DIOPT Version :10

• Sequence 1: NP_525055.1
• Gene: HLH3B / 31249
• FlyBaseID: FBgn0011276
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_722473.1
• Gene: Atoh8 / 71093
• MGIID: 1918343
• Length: 322
• Species: Mus musculus
• Alignment Length: 241
• Identity: 66/241 - (27%)
• Similarity: 90/241 - (37%)
• Gaps: 55/241 - (22%)

  Fly    46 RDTAAGRHPPALLRHATPHLQPKTESISDGDGDAELSDFSLNDTEEDEEDLRDYIVLNGNQADAN 110
            |..|.|...|.|   .||...|.::|::.||.:|.  .|.       |:.||..|:|....|...
Mouse   112 RGFALGTVGPGL---PTPPPPPASQSLAPGDPEAH--SFR-------EQALRPRILLCAPPARPT 164

  Fly   111 RSLSSSP-----RSHSRNGLLTAPA-SSGSSVGGSGGGGGNGSGGNASSGGGSGVGATGGV---- 165
            :|...:|     .|..|....|.|. ||.||:..........|..:.....|....|:..:
Mouse   165 QSAPLAPPAAPQESPVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASTEIKALQ 229

  Fly   166 --RKVFTNTRERWRQQNVSGAFAELRKLVPTHPPDKKLSKNEILRSAIKYIKLLTGILEWQQRQA 228
              |::..|.|||.|...:|.||..|||.||.:...:||||..|||.|..||..|.
Mouse   230 QTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLA---------- 284

  Fly   229 PSHPIRAQMEPNNNDNRMAN-GHAADGENLENPDVPPVRHIKCERT 273
                            |:|: .::||..||...:...    :|.||
Mouse   285 ----------------RLADLDYSADHSNLSFSECVQ----RCTRT 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	bHLH_TS_dHLH3B_like	166..225	CDD:381551	25/58 (43%)
Atoh8	NP_722473.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..96
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..144		12/36 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	159..221		13/61 (21%)
		bHLH_TS_ATOH8	225..292	CDD:381427	27/92 (29%)
		Basic motif, degenerate. /evidence=ECO:0000255|PROSITE-ProRule:PRU00981	231..244		5/12 (42%)
		Helix-loop-helix motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00981	245..283		18/37 (49%)