DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HLH3B and TAL1

DIOPT Version :9

Sequence 1:	NP_525055.1	Gene:	HLH3B / 31249	FlyBaseID:	FBgn0011276	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001274276.1	Gene:	TAL1 / 6886	HGNCID:	11556	Length:	331	Species:	Homo sapiens

Alignment Length:	324	Identity:	92/324 - (28%)
Similarity:	119/324 - (36%)	Gaps:	122/324 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NGADNADERSTASS------GSSGHSQTNESPRSGHLNGNGSMRD-------TAAGRH---PPAL 57
            ||......|:.|:.      |:.|      .|..|...|.|:.||       ||..||   ...|
Human    35 NGVAKETSRAAAAEPPVIELGARG------GPGGGPAGGGGAARDLKGRDAATAEARHRVPTTEL 93

  Fly    58 LRHATPHLQPKTESIS---DGDGDAELSDFSLNDTEEDEEDLRDYIVLNGNQADANRSLSSSPRS 119
            .|...|...|...|::   .|||                                 |.:..||.:
Human    94 CRPPGPAPAPAPASVTAELPGDG---------------------------------RMVQLSPPA 125

  Fly   120 HSRNGLLTAPASSG-------SSVGGSGGGGGNGSGG--------------------NASSGGGS 157
                  |.|||:.|       |....|.|.|..|...                    ..:.|..:
Human   126 ------LAAPAAPGRALLYSLSQPLASLGSGFFGEPDAFPMFTTNNRVKRRPSPYEMEITDGPHT 184

  Fly   158 GVGATGGVRKVFTNTRERWRQQNVSGAFAELRKLVPTHPPDKKLSKNEILRSAIKYIKLLTGILE 222
            .|     ||::|||:|||||||||:|||||||||:||||||||||||||||.|:|||..|..:|.
Human   185 KV-----VRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLN 244

  Fly   223 WQQRQA--------------------------PSHPIRAQMEPNNNDNRMANGHAADGENLENP 260
            .|:.:.                          |...::..:.||::.....:|.|:.....|.|
Human   245 DQEEEGTQRAKTGKDPVVGAGGGGGGGGGGAPPDDLLQDVLSPNSSCGSSLDGAASPDSYTEEP 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	HLH	171..222	CDD:197674	40/50 (80%)
TAL1	NP_001274276.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..86		12/51 (24%)
		HLH	193..243	CDD:197674	40/49 (82%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..331		7/60 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7474
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007786
OrthoInspector	1	1.000	-	-		otm41680
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5855
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.900