Protein Alignment HLH3B and NEUROD2

DIOPT Version :10

• Sequence 1: NP_525055.1
• Gene: HLH3B / 31249
• FlyBaseID: FBgn0011276
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_006151.3
• Gene: NEUROD2 / 4761
• HGNCID: 7763
• Length: 382
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 63/309 - (20%)
• Similarity: 106/309 - (34%)
• Gaps: 84/309 - (27%)

  Fly     4 LPSSSNGADNADERSTASSGSSGHSQTNESPRSGHLNGNGSMRDTAAGRHPPALLRHATPHLQPK 68
            :|..::..|..|:...:..|.:       .|......|.|:.....|.:..|......|.....:
Human    15 VPKFASWGDGEDDEPRSDKGDA-------PPPPPPAPGPGAPGPARAAKPVPLRGEEGTEATLAE 72

  Fly    69 TESISDGDGDAELSDFSLNDTEEDEEDLRDYIVLNGNQADANRSLSSSPRSHSRNGLLTAPASSG 133
            .:...:..|:.|       :.||:||.|        ::|:..|.....|:...    :|......
Human    73 VKEEGELGGEEE-------EEEEEEEGL--------DEAEGERPKKRGPKKRK----MTKARLER 118

  Fly   134 SSVGGSGGGGGNGSGGNASSGGGSGVGATGGVRKVFTNTRERWRQQNVSGAFAELRKLVPTHPPD 198
            |.                             :|:...|.|||.|..:::.|...|||:||.:...
Human   119 SK-----------------------------LRRQKANARERNRMHDLNAALDNLRKVVPCYSKT 154

  Fly   199 KKLSKNEILRSAIKYIKLLTGILEWQQR---------------QAPSHPIRAQMEPNNND---NR 245
            :||||.|.||.|..||..|:.||...:|               |..::.:...::.|:.:   .:
Human   155 QKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQ 219

  Fly   246 MANG----HAADGENLENPDVPPVRHIKCERTDGQMHR--NGIGHGHAN 288
            .|:|    |.:.|....:|...|     |.|..|...:  .|:|.|.|:
Human   220 GADGAGRFHGSGGPFAMHPYPYP-----CSRLAGAQCQAAGGLGGGAAH 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	bHLH_TS_dHLH3B_like	166..225	CDD:381551	25/58 (43%)
NEUROD2	NP_006151.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..129		24/168 (14%)
		bHLH_TS_NeuroD2	88..180	CDD:381563	34/132 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	107..113		0/9 (0%)
		Neuro_bHLH	180..310	CDD:463621	16/89 (18%)