Protein Alignment HLH3B and NEUROD1

DIOPT Version :10

• Sequence 1: NP_525055.1
• Gene: HLH3B / 31249
• FlyBaseID: FBgn0011276
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_002491.3
• Gene: NEUROD1 / 4760
• HGNCID: 7762
• Length: 356
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 63/306 - (20%)
• Similarity: 105/306 - (34%)
• Gaps: 82/306 - (26%)

  Fly    65 LQPKTESISDGDGDAELSDFSLNDTEEDEEDLRDYIVLNGNQADANRSLSSSPRSHSRNGLLTAP 129
            :..:.:|:.:| |:.|..|..|.:.||:||:       :.:|....|.......:.:|.....
Human    46 MNAEEDSLRNG-GEEEDEDEDLEEEEEEEEE-------DDDQKPKRRGPKKKKMTKARLERFK-- 100

  Fly   130 ASSGSSVGGSGGGGGNGSGGNASSGGGSGVGATGGVRKVFTNTRERWRQQNVSGAFAELRKLVPT 194
                                               :|::..|.|||.|...::.|...|||:||.
Human   101 -----------------------------------LRRMKANARERNRMHGLNAALDNLRKVVPC 130

  Fly   195 HPPDKKLSKNEILRSAIKYIKLLTGILEWQQRQAPSHPIRAQMEPNNNDNRMANGHAADGENL-- 257
            :...:||||.|.||.|..||..|:.||    |...|..:.:.::      .:..|.:....||
Human   131 YSKTQKLSKIETLRLAKNYIWALSEIL----RSGKSPDLVSFVQ------TLCKGLSQPTTNLVA 185

  Fly   258 -------------ENPDVPPVRHIKCERTDGQMHRNGIGHGHANGNAGNDLLMIAPGAVVKSELL 309
                         :|.|:||  |:........:      |.::..:.|   |...|...:.|..:
Human   186 GCLQLNPRTFLPEQNQDMPP--HLPTASASFPV------HPYSYQSPG---LPSPPYGTMDSSHV 239

  Fly   310 LESTLPLGHPLNGPPLPLTTAPLAMAETQRISGTVSGVKSASGRSS 355
            .. ..|..|..:....|...:||....:....|.:|...|.:|..|
Human   240 FH-VKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFS 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	bHLH_TS_dHLH3B_like	166..225	CDD:381551	25/58 (43%)
NEUROD1	NP_002491.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..94		12/55 (22%)
		bHLH_TS_NeuroD1	75..160	CDD:381562	29/132 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	87..93		0/5 (0%)
		Neuro_bHLH	160..284	CDD:463621	23/141 (16%)