DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH3B and FERD3L

DIOPT Version :9

Sequence 1:	NP_525055.1	Gene:	HLH3B / 31249	FlyBaseID:	FBgn0011276	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_690862.1	Gene:	FERD3L / 222894	HGNCID:	16660	Length:	166	Species:	Homo sapiens

Alignment Length:	169	Identity:	48/169 - (28%)
Similarity:	68/169 - (40%)	Gaps:	53/169 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 PAL-LRHATPHLQPKTESISDGDGDAELSDFSLNDTEEDEEDLRDYIVLNGNQADANRSLSSSPR 118
            ||| ||...|....:.|   :||.:.|..:....|.||:||:.|...|          ||...|:
Human    42 PALALREGRPRRMARFE---EGDPEEEECEVDQGDGEEEEEEERGRGV----------SLLGRPK 93

  Fly   119 SHSRNGLLTAPASSGSSVGGSGGGGGNGSGGNASSGGGSGVGATGGVRKVFTNTRERWRQQNVSG 183
               |..::|.                                    .::...|.|||.|..|::.
Human    94 ---RKRVITY------------------------------------AQRQAANIRERKRMFNLNE 119

  Fly   184 AFAELRKLVPTHPPDKKLSKNEILRSAIKYIKLLTGILE 222
            ||.:||:.|||...:|:||:.|.||.||.||..:|.:||
Human   120 AFDQLRRKVPTFAYEKRLSRIETLRLAIVYISFMTELLE 158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	HLH	171..222	CDD:197674	24/50 (48%)
FERD3L	NP_690862.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..88		11/43 (26%)
FERD3L	NP_690862.1	bHLH_TS_FERD3L_NATO3	94..157	CDD:381421	26/98 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810