Protein Alignment HLH3B and Twist1

DIOPT Version :10

• Sequence 1: NP_525055.1
• Gene: HLH3B / 31249
• FlyBaseID: FBgn0011276
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_035788.1
• Gene: Twist1 / 22160
• MGIID: 98872
• Length: 206
• Species: Mus musculus
• Alignment Length: 169
• Identity: 56/169 - (33%)
• Similarity: 81/169 - (47%)
• Gaps: 41/169 - (24%)

  Fly    82 SDFSLNDTEEDEEDLRDYIVLNGNQADANRSLSSSPRSHSR---NGLLTAPASSGSSVGG----- 138
            :|.||:::||:.:          .|..|:....:..|..||   .|......::|..:||
Mouse    13 ADDSLSNSEEEPD----------RQQPASGKRGARKRRSSRRSAGGSAGPGGATGGGIGGGDEPG 67

  Fly   139 -----------SGGGGGNGSGGNASSGGGSGVGATGG---------VRKVFTNTRERWRQQNVSG 183
                       :|||||.|:||....||||..|  ||         .::|..|.|||.|.|:::.
Mouse    68 SPAQGKRGKKSAGGGGGGGAGGGGGGGGGSSSG--GGSPQSYEELQTQRVMANVRERQRTQSLNE 130

  Fly   184 AFAELRKLVPTHPPDKKLSKNEILRSAIKYIKLLTGILE 222
            |||.|||::||.|.| ||||.:.|:.|.:||..|..:|:
Mouse   131 AFAALRKIIPTLPSD-KLSKIQTLKLAARYIDFLYQVLQ 168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	bHLH_TS_dHLH3B_like	166..225	CDD:381551	27/57 (47%)
Twist1	NP_035788.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..109		29/107 (27%)
		bHLH_TS_TWIST1	102..178	CDD:381418	28/68 (41%)
		Sufficient for transactivation activity	165..195		1/4 (25%)