DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH3B and Ptf1a

DIOPT Version :9

Sequence 1:	NP_525055.1	Gene:	HLH3B / 31249	FlyBaseID:	FBgn0011276	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_061279.2	Gene:	Ptf1a / 19213	MGIID:	1328312	Length:	324	Species:	Mus musculus

Alignment Length:	180	Identity:	54/180 - (30%)
Similarity:	82/180 - (45%)	Gaps:	28/180 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RDTAAGRHPPALLRHATPHLQPKTESISDGDGDAELSDFSLNDTEEDEEDLRDYIVLNGNQADAN 110
            ||.|.....||  ..|.||               .|:...|.|..|.|::: .|.      .||.
Mouse    63 RDGACLLLQPA--PSAAPH---------------ALAPPPLGDPGEPEDNV-SYC------CDAG 103

  Fly   111 RSLSSSPRS-HSRNGLLTAPASSGSSVGGSGGGGGNGSGGNASSGGGSGVGATGGVRKV--FTNT 172
            ..|::.|.| .|....|..|.::..| .|:..||.||:...|::.....|.:...::::  ..|.
Mouse   104 APLAAFPYSPGSPPSCLAYPCAAVLS-PGARLGGLNGAAAAAAARRRRRVRSEAELQQLRQAANV 167

  Fly   173 RERWRQQNVSGAFAELRKLVPTHPPDKKLSKNEILRSAIKYIKLLTGILE 222
            |||.|.|:::.||..||..:||.|.:|:|||.:.||.||.||..|:.:::
Mouse   168 RERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQ 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	HLH	171..222	CDD:197674	24/50 (48%)
Ptf1a	NP_061279.2	HLH	162..217	CDD:238036	24/54 (44%)
Ptf1a	NP_061279.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..324
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810