Protein Alignment HLH3B and Neurod2

DIOPT Version :10

• Sequence 1: NP_525055.1
• Gene: HLH3B / 31249
• FlyBaseID: FBgn0011276
• Length: 376
• Species: Drosophila melanogaster
• Sequence 2: NP_035025.3
• Gene: Neurod2 / 18013
• MGIID: 107755
• Length: 383
• Species: Mus musculus
• Alignment Length: 309
• Identity: 64/309 - (20%)
• Similarity: 112/309 - (36%)
• Gaps: 83/309 - (26%)

  Fly     4 LPSSSNGADNADERSTASSGSSGHSQTNESPRSGHLNGNGSMRDTAAGRHPPALLRHATPHLQPK 68
            :|..::..|..|:...:..|.:       .|:.....|:|:.....|.:  |..||......:|.
Mouse    15 VPKFASWGDGDDDEPRSDKGDA-------PPQPPPAPGSGAPGPARAAK--PVSLRGGEEIPEPT 70

  Fly    69 TESISDGDGDAELSDFSLNDTEEDEEDLRDYIVLNGNQADANRSLSSSPRSHSRNGLLTAPASSG 133
            ...:.: :|:       |...||:||:..:.:    ::|:..|.....|:...    :|......
Mouse    71 LAEVKE-EGE-------LGGEEEEEEEEEEGL----DEAEGERPKKRGPKKRK----MTKARLER 119

  Fly   134 SSVGGSGGGGGNGSGGNASSGGGSGVGATGGVRKVFTNTRERWRQQNVSGAFAELRKLVPTHPPD 198
            |.                             :|:...|.|||.|..:::.|...|||:||.:...
Mouse   120 SK-----------------------------LRRQKANARERNRMHDLNAALDNLRKVVPCYSKT 155

  Fly   199 KKLSKNEILRSAIKYIKLLTGILEWQQR---------------QAPSHPIRAQMEPNNND---NR 245
            :||||.|.||.|..||..|:.||...:|               |..::.:...::.|:.:   .:
Mouse   156 QKLSKIETLRLAKNYIWALSEILRSGKRPDLVSYVQTLCKGLSQPTTNLVAGCLQLNSRNFLTEQ 220

  Fly   246 MANG----HAADGENLENPDVPPVRHIKCERTDGQMHR--NGIGHGHAN 288
            .|:|    |.:.|....:|...|     |.|..|...:  .|:|.|.|:
Mouse   221 GADGAGRFHGSGGPFAMHPYPYP-----CSRLAGAQCQAAGGLGGGAAH 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	bHLH_TS_dHLH3B_like	166..225	CDD:381551	25/58 (43%)
Neurod2	NP_035025.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..130		25/168 (15%)
		bHLH_TS_NeuroD2	89..181	CDD:381563	30/128 (23%)
		Nuclear localization signal. /evidence=ECO:0000255	108..114		0/9 (0%)
		Neuro_bHLH	181..311	CDD:463621	16/89 (18%)