DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH3B and Lyl1

DIOPT Version :9

Sequence 1:	NP_525055.1	Gene:	HLH3B / 31249	FlyBaseID:	FBgn0011276	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_032561.2	Gene:	Lyl1 / 17095	MGIID:	96891	Length:	278	Species:	Mus musculus

Alignment Length:	244	Identity:	83/244 - (34%)
Similarity:	98/244 - (40%)	Gaps:	80/244 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TAAGRHPPALLRHATPHLQPKTESISDGDGDAELSDFSLNDTEEDEEDLRDYIVLNGNQADANRS 112
            ||.||.||.|..|..||  |...|:..|..    ..||:                     ..|..
Mouse    90 TALGRAPPTLAVHYHPH--PFLNSVYIGPA----GPFSI---------------------FPNSR 127

  Fly   113 LSSSPRSHSRNGLLTAPASSGSSVGGSGGGGGNGSGGNASSGGGSGVGATGGVRKVFTNTRERWR 177
            |...| |||...|  |.......|                            .|:||||:|||||
Mouse   128 LKRRP-SHSELDL--ADGHQPQKV----------------------------ARRVFTNSRERWR 161

  Fly   178 QQNVSGAFAELRKLVPTHPPDKKLSKNEILRSAIKYIKLLTGILEWQQR------QAPSH---PI 233
            ||:|:|||||||||:||||||:||||||:||.|:|||..|..:|..|..      .||..   |.
Mouse   162 QQHVNGAFAELRKLLPTHPPDRKLSKNEVLRLAMKYIGFLVRLLRDQTAVLTSGPSAPGSRKPPA 226

  Fly   234 RAQMEPNNNDNRMANGHAADGENLENPDVP---------PVRHIKCERT 273
            |..:|   ...|...||..:... ..|.:|         .||.||.|:|
Mouse   227 RRGVE---GSARFGAGHRVEAAR-SQPVLPGDCDGDPNGSVRPIKLEQT 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	HLH	171..222	CDD:197674	37/50 (74%)
Lyl1	NP_032561.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		bHLH_TS_LYL1	145..209	CDD:381548	43/91 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..278		16/64 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7447
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43728
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13864
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5855
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.900