DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH3B and Hand1

DIOPT Version :9

Sequence 1:	NP_525055.1	Gene:	HLH3B / 31249	FlyBaseID:	FBgn0011276	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_032239.1	Gene:	Hand1 / 15110	MGIID:	103577	Length:	216	Species:	Mus musculus

Alignment Length:	129	Identity:	37/129 - (28%)
Similarity:	61/129 - (47%)	Gaps:	8/129 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 RSHSRNGLLT-APASSGSSVGG-------SGGGGGNGSGGNASSGGGSGVGATGGVRKVFTNTRE 174
            |.:.::.||: |.|:.....||       :....|..:..:.|.|....:|:....||.....:|
Mouse    39 RPYFQSWLLSPADAAPDFPAGGPPPTTAVAAAAYGPDARPSQSPGRLEALGSRLPKRKGSGPKKE 103

  Fly   175 RWRQQNVSGAFAELRKLVPTHPPDKKLSKNEILRSAIKYIKLLTGILEWQQRQAPSHPIRAQME 238
            |.|.::::.||||||:.:|..|.|.||||.:.||.|..||..|..:|....:.......:|:::
Mouse   104 RRRTESINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDVLAKDAQAGDPEAFKAELK 167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	HLH	171..222	CDD:197674	22/50 (44%)
Hand1	NP_032239.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..109		11/55 (20%)
		HLH	103..152	CDD:197674	23/48 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..203		0/3 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810