DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH3B and MESP2

DIOPT Version :9

Sequence 1:	NP_525055.1	Gene:	HLH3B / 31249	FlyBaseID:	FBgn0011276	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001035047.1	Gene:	MESP2 / 145873	HGNCID:	29659	Length:	397	Species:	Homo sapiens

Alignment Length:	328	Identity:	74/328 - (22%)
Similarity:	105/328 - (32%)	Gaps:	113/328 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 TAPASSGSSVGGSGGGGGNG-------------SGGNASSGGGSGVGATGGVRKVFTNTRERWRQ 178
            |:||||..|.|.....|..|             :...|::...:..|..||.|: ..:.||:.|.
Human    31 TSPASSSDSSGSCPCDGARGLPQPQPPSCSSRAAEAAATTPRRARTGPAGGQRQ-SASEREKLRM 94

  Fly   179 QNVSGAFAELRKLVPTH--PPDKKLSKNEILRSAIKYIKLLTGI-------LEWQQRQ------- 227
            :.::.|..|||:.:|..  |..:.|:|.|.||.||:||..|:.:       |:.::||
Human    95 RTLARALHELRRFLPPSLAPAGQSLTKIETLRLAIRYIGHLSAVLGLSEESLQCRRRQRGDAGSP 159

  Fly   228 --APSHPIRAQMEPNNNDNRMANGHAADGENLENPDVPPVRHIKCERTDGQMHRNGIGHGHANGN 290
              .|..|.|...|..........|..                    :..||....|.|.|...|.
Human   160 WGCPLCPDRGPAEAQTQAEGQGQGQG--------------------QGQGQGQGQGQGQGQGQGQ 204

  Fly   291 AGNDLLMIA-------------PGAVVKSELL------------------LES------------ 312
            .....|:.|             |||....|.|                  ::|
Human   205 GRRPGLVSAVLAEASWGSPSACPGAQAAPERLGRGVHDTDPWATPPYCPKIQSPPYSSQGTTSDA 269

  Fly   313 ---TLPLGHPL-------NGPPLPLTTAPLAMAETQRISG-TVS-------GVKSASGRSSKRRL 359
               |.|.|.|.       ..||:|.|.||..:.......| :||       |..|.....|.:||
Human   270 SLWTPPQGCPWTQSSPEPRNPPVPWTAAPATLELAAVYQGLSVSPEPCLSLGAPSLLPHPSCQRL 334

  Fly   360 KPE 362
            :|:
Human   335 QPQ 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	HLH	171..222	CDD:197674	19/59 (32%)
MESP2	NP_001035047.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..92		16/61 (26%)
		HLH	82..135	CDD:278439	19/53 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..208		12/75 (16%)
		13 X 2 AA tandem repeats of G-Q	179..204		6/44 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	222..295		13/72 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..376
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810