DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HLH3B and Ptf1a

DIOPT Version :9

Sequence 1:	NP_525055.1	Gene:	HLH3B / 31249	FlyBaseID:	FBgn0011276	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_446416.1	Gene:	Ptf1a / 117034	RGDID:	621709	Length:	326	Species:	Rattus norvegicus

Alignment Length:	220	Identity:	57/220 - (25%)
Similarity:	84/220 - (38%)	Gaps:	55/220 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 TNESPRSGHLNGNGSMRDTAAG-------------RHPPALLRHATPHLQPKTESISDGDGDAEL 81
            |::|.|....:|:..:.|..|.             |....||....|...|..           |
  Rat    28 TDQSSRDPLEDGDELLGDEQAEVEFLSHQLHEYCYRDGACLLLQPAPSAAPHA-----------L 81

  Fly    82 SDFSLNDTEEDEEDLRDYIVLNGNQ-ADANRSLSSSPRS-HSRNGLL----TAPASSGSSVGGSG 140
            :...|.|..|.|:        :|:. .||...|.:.|.| .|....|    ||..|.|:.:.|..
  Rat    82 APPPLGDPGEPED--------SGSYCCDAGAPLGAFPYSPGSPPSCLAYPCTAVLSPGTRLRGLN 138

  Fly   141 GGGGNGSGGNASSGGGSGVGATGGVR--------KVFTNTRERWRQQNVSGAFAELRKLVPTHPP 197
            |         |::...:.......||        :...|.|||.|.|:::.||..||..:||.|.
  Rat   139 G---------AAAAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPY 194

  Fly   198 DKKLSKNEILRSAIKYIKLLTGILE 222
            :|:|||.:.||.||.||..|:.:::
  Rat   195 EKRLSKVDTLRLAIGYINFLSELVQ 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HLH3B	NP_525055.1	HLH	171..222	CDD:197674	24/50 (48%)
Ptf1a	NP_446416.1	bHLH_TS_PTF1A	164..218	CDD:381423	24/53 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..249
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..326
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4029
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810