DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sgg and MRK1

DIOPT Version :9

Sequence 1:	NP_001259193.1	Gene:	sgg / 31248	FlyBaseID:	FBgn0003371	Length:	1168	Species:	Drosophila melanogaster
Sequence 2:	NP_010204.1	Gene:	MRK1 / 851480	SGDID:	S000002237	Length:	501	Species:	Saccharomyces cerevisiae

Alignment Length:	603	Identity:	204/603 - (33%)
Similarity:	307/603 - (50%)	Gaps:	139/603 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   401 SEEQRKKRNTTVASNLAASGAVVDDTKDDYKQQPHCDT----SSRSKNNSVPNPPSSHLHQNHNH 461
            |:..:.|..|::.||.|.         :..|::|  ||    |....:::|||      ..|.:.
Yeast    17 SDNLQLKHKTSIQSNTAL---------EKKKRKP--DTIKKVSDVQVHHTVPN------FNNSSE 64

  Fly   462 LVVDVQEDVDDVNVVATSDVDSGVVKMRRHSHDNHYDRIPRSNAATITTRPQIDQQSSHHQNTED 526
            .:.|::      |::.:..:|.|                          :..|......|.|.
Yeast    65 YINDIE------NLIISKLIDGG--------------------------KEGIAVDHIEHANI-- 95

  Fly   527 VEQGAEPQIDGEADLDADADADSDGSGENVKTAKLARTQSCVSWTKVVQKFKNILG--MKQLIGK 589
                              :|:.:||                    ||..|.:||..  .|:.:.|
Yeast    96 ------------------SDSKTDG--------------------KVANKHENISSKLSKEKVEK 122

  Fly   590 LNDL------WPEHSVALSIPK-----EVDRSKEKLEGAWETTGRDGSKITTVVATPGQGTDRVQ 643
            :.:.      ..|.::...:.|     :|||...            |..|
Yeast   123 MINFDYRYIKTKERTIHKRVYKHDRKTDVDRKNH------------GGTI--------------- 160

  Fly   644 EVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFY 708
            ::||..|:|:|:||||||....:.:|.:.|||||||||||:|||||:.|:.|.|.|.|.|.|:||
Yeast   161 DISYPTTEVVGHGSFGVVVTTVIIETNQKVAIKKVLQDRRYKNRELETMKMLCHPNTVGLQYYFY 225

  Fly   709 SSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSL-GICHRD 772
            ...|: |||:|||||:|:|:::|:..|.:...|..:|...|:.|.||||::|.|:|:: .|||||
Yeast   226 EKDEE-DEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRICHRD 289

  Fly   773 IKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCV 837
            |||||||:||.|...|:|||||||.|...:||||||||||||||||:|||.||:.::||||:.||
Yeast   290 IKPQNLLVDPTTFSFKICDFGSAKCLKPDQPNVSYICSRYYRAPELMFGATNYSNQVDVWSSACV 354

  Fly   838 LAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPT 902
            :||||||:|:|.|:||:|||||:||::|.||:::|..|||||.:..||.||.....::|:...|
Yeast   355 IAELLLGKPLFSGESGIDQLVEIIKIMGIPTKDEISGMNPNYEDHVFPNIKPITLAEIFKAEDP- 418

  Fly   903 EAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNF-TEHELSIQPSLV 966
            :.::|::..|:|.|..|:.||:.....:|||.:.....|....::: .:|:| .|.||...|.:.
Yeast   419 DTLDLLTKTLKYHPCERLVPLQCLLSSYFDETKRCDTDTYVKAQNL-RIFDFDVETELGHVPLVE 482

  Fly   967 PQLLPKHLQN-ASGPGGN 983
            ...:.:.|:: .|.|..:
Yeast   483 RPAIEERLKHFVSAPSSS 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgg	NP_001259193.1	STKc_GSK3	643..934	CDD:271039	154/291 (53%)
sgg	NP_001259193.1	S_TKc	647..931	CDD:214567	151/284 (53%)
MRK1	NP_010204.1	STKc_GSK3	159..449	CDD:271039	154/306 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343773
Domainoid	1	1.000	344	1.000	Domainoid score	I149
eggNOG	1	0.900	-	-		E2759_KOG0658
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	354	1.000	Inparanoid score	I387
Isobase	1	0.950	-	0	Normalized mean entropy	S376
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000635
OrthoInspector	1	1.000	-	-		mtm9205
orthoMCL	1	0.900	-	-		OOG6_100482
Panther	1	1.100	-	-	O	PTHR24057
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X378
TreeFam	1	0.960	-	-
	12	11.700