DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sgg and gsk3aa

DIOPT Version :9

Sequence 1:	NP_001259193.1	Gene:	sgg / 31248	FlyBaseID:	FBgn0003371	Length:	1168	Species:	Drosophila melanogaster
Sequence 2:	NP_001038386.2	Gene:	gsk3aa / 560194	ZFINID:	ZDB-GENE-060503-796	Length:	462	Species:	Danio rerio

Alignment Length:	497	Identity:	311/497 - (62%)
Similarity:	357/497 - (71%)	Gaps:	54/497 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 AEPQID-GEAD----LDADADADSDGSGENVKTAKLARTQSCVSWTKVVQKFKNILGMKQLIGKL 590
            |..|:| |.||    ...:..:|..||| ..:|:..|..|. .|.|....     .|...::|.
Zfish     5 APGQVDEGSADRRPTASVNFQSDMSGSG-RPRTSSFAEPQG-ASGTAAAS-----AGTAAVVGS- 61

  Fly   591 NDLWPEHSVALSIPKEVDRSKE----KLEGAWETTGRDGSKITTVVATPGQGTDRVQEVSYTDTK 651
            |...|..|.|     ..|.|..    ||       .||..|:||||||||||.||.|||||||.|
Zfish    62 NAGKPGVSQA-----SADSSSACANLKL-------ARDSGKVTTVVATPGQGPDRPQEVSYTDIK 114

  Fly   652 VIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNRELQIMRKLEHCNIVKLLYFFYSSGEKRDE 716
            ||||||||||:||:|.||.|.|||||||||:|||||||||||||:|||||:|.||||.||||:||
Zfish   115 VIGNGSFGVVYQARLIDTHEWVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYCSGEKKDE 179

  Fly   717 VFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLD 781
            |:|||||:|:|||||:|||.::|.|..|||.::::||||||||||||||.|:|||||||||||:|
Zfish   180 VYLNLVLDYVPETVYRVARHFSKAKTIIPIFYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVD 244

  Fly   782 PETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPELIFGAINYTTKIDVWSAGCVLAELLLGQP 846
            |||||||||||||||||:.||||||||||||||||||||||.:||:.||:|||||||||||||||
Zfish   245 PETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSNIDIWSAGCVLAELLLGQP 309

  Fly   847 IFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEFKFPQIKSHPWQKVFRIRTPTEAINLVSLL 911
            |||||||||||||:||||||||||||||||||||||||||||:|||.|||:.|||.|||.|.|.|
Zfish   310 IFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKPRTPPEAIALCSRL 374

  Fly   912 LEYTPSARITPLKACAHPFFDELRMEGNHTLPNGRDMPPLFNFTEHELSIQPSLVPQLLPKHLQN 976
            |||||..|::||:||||.||||||..|.. ||:||::|||||||..||.|||.|...|:|.|.:
Zfish   375 LEYTPVTRLSPLQACAHAFFDELRQPGTR-LPSGRELPPLFNFTTTELMIQPQLNSTLIPPHAR- 437

  Fly   977 ASGPGGNRPSAGGAASIAASGSTSVSSTGSGASVEGSAQPQS 1018
                                 :.:|:|:..|:  |||.||.|
Zfish   438 ---------------------AQTVASSNDGS--EGSVQPGS 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgg	NP_001259193.1	STKc_GSK3	643..934	CDD:271039	238/290 (82%)
sgg	NP_001259193.1	S_TKc	647..931	CDD:214567	231/283 (82%)
gsk3aa	NP_001038386.2	STKc_GSK3	105..397	CDD:271039	238/291 (82%)
gsk3aa	NP_001038386.2	Pkinase	110..394	CDD:278497	231/283 (82%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580560
Domainoid	1	1.000	514	1.000	Domainoid score	I304
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	631	1.000	Inparanoid score	I822
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D990896at2759
OrthoFinder	1	1.000	-	-		FOG0000635
OrthoInspector	1	1.000	-	-		otm25264
orthoMCL	1	0.900	-	-		OOG6_100482
Panther	1	1.100	-	-	O	PTHR24057
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R530
SonicParanoid	1	1.000	-	-		X378
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.930