DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sgg and MYLK

DIOPT Version :9

Sequence 1:	NP_001259193.1	Gene:	sgg / 31248	FlyBaseID:	FBgn0003371	Length:	1168	Species:	Drosophila melanogaster
Sequence 2:	XP_024309300.1	Gene:	MYLK / 4638	HGNCID:	7590	Length:	1924	Species:	Homo sapiens

Alignment Length:	952	Identity:	197/952 - (20%)
Similarity:	309/952 - (32%)	Gaps:	349/952 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 QLPPPRSSS--------GSLSLPQAPPGGKWRQK------QQRQQLLLSQDSGIENGV------- 130
            ::|||:.::        |...|| |..|....:.      :..:.|..:|.||....|
Human   980 KVPPPKPATPDFRSVLGGKKKLP-AENGSSSAETLNAKAVESSKPLSNAQPSGPLKPVGNAKPAE 1043

  Fly   131 ------TTRPSKAKDNQGAGKASHNATS-SKE----------------SGAQSNSS-SESLGSNC 171
                  ..:|::.....|..|...|..| |||                :|...|.. |||.|:..
Human  1044 TLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRGHAGTTDNEKRSESQGTAP 1108

  Fly   172 SEAQEQQRVRASSALEL-----SSVDTPVIVGGVVSGGNSILRSRIKYKSTNSTGTQGFDVEDRI 231
            :..|:.|.|..:...:|     .|.|.|..:...::|           |:..:|.......|..:
Human  1109 AFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNG-----------KTLKTTKFIILSQEGSL 1162

  Fly   232 DEVDICDDDDVDCDDRGSEIEEEEEEEEDDGVNVDDDVEEADNQSDNQSGIIINLKSQTEQEEEV 296
            ..|.|                 |:...||.|:.......:| .|::....:.::....:|..:..
Human  1163 CSVSI-----------------EKALPEDRGLYKCVAKNDA-GQAECSCQVTVDDAPASENTKAP 1209

  Fly   297 DEVDAKPKNRLLPP---DQAELTVAAAMARRRDAKSLATDGHIYFPLLKISEDPHIDS----KLI 354
            :....:||:. |||   .:::.||....|.:...|:......|.||     ||..:.:    :|.
Human  1210 EMKSRRPKSS-LPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFP-----EDQKVRAGESVELF 1268

  Fly   355 NRKDGLQD-TMYYLDEFGSPKLREKFARKQKQLLAKQQKQLMKRERRSEEQRKKRNTTVASNLAA 418
            .:..|.|. |..::          || |||.|               ..|..|..|:...|.|..
Human  1269 GKVTGTQPITCTWM----------KF-RKQIQ---------------ESEHMKVENSENGSKLTI 1307

  Fly   419 SGAVVDDTKDDYKQQPHCDTSSRSKNNSV--------------PNPPSSHLHQNHNHLVVDVQED 469
            ..|          :|.||...:....|.:              |:||:
Human  1308 LAA----------RQEHCGCYTLLVENKLGSRQAQVNLTVVDKPDPPA----------------- 1345

  Fly   470 VDDVNVVATSDVDSGVVKMRRHSHDNHYDRIPRSNAATITTRPQIDQQSSHHQNTEDVEQGAEPQ 534
                .....||:                    ||::.|::.     ..||:
Human  1346 ----GTPCASDI--------------------RSSSLTLSW-----YGSSY-------------- 1367

  Fly   535 IDGEADLDADADADSDGSGENVKTAKLARTQSCVSWTKVVQKFKNILGMKQLIGKLNDLWPEHSV 599
             ||             ||.        .::.|...|....:.:|.:...:.....:.||.|:|..
Human  1368 -DG-------------GSA--------VQSYSIEIWDSANKTWKELATCRSTSFNVQDLLPDHEY 1410

  Fly   600 -----ALSIPKEVDRSKEKLEGAWETTGRDGSKITTVVATPGQGTDRVQ---------EVSY--- 647
                 |:::....:.|:|             |::|||...|.:..|.|:         ||.|
Human  1411 KFRVRAINVYGTSEPSQE-------------SELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTV 1462

  Fly   648 ---TDTKV---------IGNGSFGVVFQAKLCDTGELVAIK--KVLQDRRFK----------NRE 688
               |:.||         :|:|.||.||:        ||..|  ||...:.||          .:|
Human  1463 TINTEQKVSDFYDIEERLGSGKFGQVFR--------LVEKKTRKVWAGKFFKAYSAKEKENIRQE 1519

  Fly   689 LQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLE----------YIPETVYKVARQYAKTKQT 743
            :.||..|.|..:|:.:..|   .||.:.|   :|||          .|.|......|:..|
Human  1520 ISIMNCLHHPKLVQCVDAF---EEKANIV---MVLEIVSGGELFERIIDEDFELTERECIK---- 1574

  Fly   744 IPINFIRLYMYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAV-LKLCDFGSAKQL--------L 799
                    ||.|:...:.|||..||.|.|:||:|::...:|.. :||.|||.|::|        |
Human  1575 --------YMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKVL 1631

  Fly   800 HGEPNVSYICSRYYRAPELI-FGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKV 863
            .|.|.        :.|||:| :..|.|.|  |:||.|.:...|:.|...|.||:..:.|..|...
Human  1632 FGTPE--------FVAPEVINYEPIGYAT--DMWSIGVICYILVSGLSPFMGDNDNETLANVTSA 1686

  Fly   864 LGTPTREQIREMNPNYTEF-------------KFPQIKSHPW 892
            ......|...|::.:..:|             ...|...|||
Human  1687 TWDFDDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPW 1728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgg	NP_001259193.1	STKc_GSK3	643..934	CDD:271039	85/319 (27%)
sgg	NP_001259193.1	S_TKc	647..931	CDD:214567	83/306 (27%)
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352	19/117 (16%)
		Ig8_hMLCK_like	1248..1345	CDD:143239	27/137 (20%)
		FN3	1341..1433	CDD:238020	25/186 (13%)
		STKc_MLCK1	1471..1729	CDD:271093	79/294 (27%)
		I-set	1819..1909	CDD:254352
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000