DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sgg and gsk3b

DIOPT Version :9

Sequence 1:	NP_001259193.1	Gene:	sgg / 31248	FlyBaseID:	FBgn0003371	Length:	1168	Species:	Drosophila melanogaster
Sequence 2:	XP_017945668.1	Gene:	gsk3b / 100489648	XenbaseID:	XB-GENE-487098	Length:	426	Species:	Xenopus tropicalis

Alignment Length:	399	Identity:	303/399 - (75%)
Similarity:	338/399 - (84%)	Gaps:	11/399 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 RDGSKITTVVATPGQGTDRVQEVSYTDTKVIGNGSFGVVFQAKLCDTGELVAIKKVLQDRRFKNR 687
            :||||:||||||||||.||.|||||||||||||||||||:|||||||||||||||||||:|||||
Frog    32 KDGSKVTTVVATPGQGPDRQQEVSYTDTKVIGNGSFGVVYQAKLCDTGELVAIKKVLQDKRFKNR 96

  Fly   688 ELQIMRKLEHCNIVKLLYFFYSSGEKRDEVFLNLVLEYIPETVYKVARQYAKTKQTIPINFIRLY 752
            ||||||||:|||||:|.|||||||||:|||:|||||:|:|||||:|||.|::.||.:|:.:::||
Frog    97 ELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQALPMIYVKLY 161

  Fly   753 MYQLFRSLAYIHSLGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLLHGEPNVSYICSRYYRAPE 817
            |||||||||||||.||||||||||||||||||||||||||||||||:.|||||||||||||||||
Frog   162 MYQLFRSLAYIHSFGICHRDIKPQNLLLDPETAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPE 226

  Fly   818 LIFGAINYTTKIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEVIKVLGTPTREQIREMNPNYTEF 882
            |||||.:||:.|||||||||||||||||||||||||||||||:||||||||||||||||||||||
Frog   227 LIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEF 291

  Fly   883 KFPQIKSHPWQK------VFRIRTPTEAINLVSLLLEYTPSARITPLKACAHPFFDELRMEGNHT 941
            ||||||:|||.|      |||.|||.|||.|.|.||||||:||:|||.||||.|||||| :.|..
Frog   292 KFPQIKAHPWTKGYVFLQVFRARTPPEAIALCSRLLEYTPTARLTPLDACAHSFFDELR-DPNLK 355

  Fly   942 LPNGRDMPPLFNFTEHELSIQPSLVPQLLPKHLQN-ASGPGGNRPSAGGAASIAASGSTSVSSTG 1005
            |||||:.|.|||||..|||..|||...|:|.|.:| ||.|   .||...:||..::|....|:..
Frog   356 LPNGREFPALFNFTTQELSSNPSLSSILIPAHARNQASVP---TPSNSTSASETSTGERCTSTNA 417

  Fly  1006 SGASVEGSA 1014
            :.||...|:
Frog   418 ASASASNSS 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sgg	NP_001259193.1	STKc_GSK3	643..934	CDD:271039	250/296 (84%)
sgg	NP_001259193.1	S_TKc	647..931	CDD:214567	243/289 (84%)
gsk3b	XP_017945668.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	509	1.000	Domainoid score	I326
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	615	1.000	Inparanoid score	I884
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D990896at2759
OrthoFinder	1	1.000	-	-		FOG0000635
OrthoInspector	1	1.000	-	-		otm48031
Panther	1	1.100	-	-	O	PTHR24057
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160