Protein Alignment Pi4KIIIalpha and PIK1

DIOPT Version :10

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_014132.1
• Gene: PIK1 / 855454
• SGDID: S000005211
• Length: 1066
• Species: Saccharomyces cerevisiae
• Alignment Length: 1173
• Identity: 261/1173 - (22%)
• Similarity: 427/1173 - (36%)
• Gaps: 405/1173 - (34%)

  Fly  1225 IICSEISRKLLHAVASSQLELFTESAMETAVECWQWVLT-------ARQDLELCFIQE-----MV 1277
            ::|.......:|.....:|..|..|.::..:.....||.       |.:||.|....|     ::
Yeast    40 LLCKHSENIGIHYYLCQKLATFPHSELQFYIPQLVQVLVTMETESMALEDLLLRLRAENPHFALL 104

  Fly  1278 SAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPIL-----------------------IAPH 1319
            :.||        |.|..|:::...|:| |.: |::.:|                       :||.
Yeast   105 TFWQ--------LQALLTDLSTDPASY-GFQ-VARRVLNNLQTNLFNTSSGSDKNVKIHENVAPA 159

  Fly  1320 LIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLS----- 1379
            |:    ||.|:.:|        ..|..|.....|::: |:..||.:.|   |||.:..:.
Yeast   160 LV----LSSMIMSA--------IAFPQLSEVTKPLVE-SQGRRQKAFV---FKLARSAMKDFTKN 208

  Fly  1380 -LLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCP----------------------------- 1414
             .|:...:.|..||:   :|:.||.    ...||.|
Yeast   209 MTLKNTLLNKKTSRS---KRVSSNR----SSTPTSPIDLIDPIKTKEDASFRKSRHSEVKLDFDI 266

  Fly  1415 -----NQSREQLLEDIMILLKFWQTMRSEKKHLVTSEV-GDYDLTN----ASVSSTQMLAVRNNP 1469
                 ||..|:.:...:.|.|      .:.|:|..|.| ..||..|    .|:|:
Yeast   267 VDDIGNQVFEERISSSIKLPK------RKPKYLDNSYVHRTYDGKNINRDGSISN---------- 315

  Fly  1470 ETASLISGGGLVNDY--TRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQ 1532
             ||..:.|.  ..||  .:..:...|.:|......||                         ..:
Yeast   316 -TAKALDGN--KGDYISPKGRNDENNEIGNNEDETGG-------------------------ETE 352

  Fly  1533 YQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPDL--IVP-----------GEEQITEWR 1584
            ...|:.:.|:.                      .:|:|||  |.|           |..::....
Yeast   353 EDADALNSDHF----------------------TSSMPDLHNIQPRTSSASSASLEGTPKLNRTN 395

  Fly  1585 NRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALK---YL 1646
            ::|...                      |..||::..:..:|:.:....::.....:.||   :.
Yeast   396 SQPLSR----------------------QAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFR 438

  Fly  1647 CTTK---NLLQESPDLVYILSWSPVTPIQA-LAYFSRQYPS----------------HPL---TA 1688
            |.|:   .|...|..|..:.:.:.::.::| |...:|..|:                |.|   ||
Yeast   439 CETQFAIALETISQRLARVPTEARLSALRAELFLLNRDLPAEVDIPTLLPPNKKGKLHKLVTITA 503

  Fly  1689 QYAVKTLSSYPAESVLPYIPQLVQALRHD-----TMGYVVEFIKNISRRSQIVAHQ--LIWNMQT 1746
            ..| :.|:|  ||.| ||: .|::.||.:     |.......:|.||      .:|  ||:::.
Yeast   504 NEA-QVLNS--AEKV-PYL-LLIEYLRDEFDFDPTSETNERLLKKIS------GNQGGLIFDLN- 556

  Fly  1747 NMYMDEDQQHKDPNLYEALDQLSQSII---ASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGI 1808
              ||:..:.:::.|........::|.:   .||:..|.| .|.........:|.:..:|:..
Yeast   557 --YMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASR-NEGLSSTSRSDSASTAHVRTEV--- 615

  Fly  1809 ERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLA--------------- 1858
             .|...|..:|.:||:.    .::.||      |.:...:||||..|.|.
Yeast   616 -NKEEDLGDMSMVKVRN----RTDDEA------YRNALVIQSAANVPILPDDSQDRSPELNFGSN 669

  Fly  1859 ------------------------RFRVYRCGITEL------------ETRAMEVSNNPNSQ--- 1884
                                    :.||....:.:|            :.||..:|:....|
Yeast   670 LDEVLIENGINSKNIHSQTDALADQMRVSAVMLAQLDKSPQQLSESTKQIRAQIISSMKEVQDKF 734

  Fly  1885 -----------------EDAKMTLGV-------------------------ESWQ--AAIFKVGD 1905
                             |:..||.|:                         |:|.  :.|.|.||
Yeast   735 GYHDLEALHGMAGERKLENDLMTGGIDTSYLGEDWATKKERIRKTSEYGHFENWDLCSVIAKTGD 799

  Fly  1906 DVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQ------- 1963
            |:||:..|.|:|....||:.:..:|:::...:::.|:...|::|.:.||.|...:.:.
Yeast   800 DLRQEAFAYQMIQAMANIWVKEKVDVWVKRMKILITSANTGLVETITNAMSVHSIKKALTKKMIE 864

  Fly  1964 ----TDSG----LSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKD 2020
                .|.|    |:::|...:|:.:..:::.|:.||..|:||||:|.||||:|||||||||||.:
Yeast   865 DAELDDKGGIASLNDHFLRAFGNPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDNE 929

  Fly  2021 GHIIHIDFGFMFESSPGGNIGFE-PDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQD 2084
            ||:.|||||||..:|| |::||| ...|||.|.:.::|| ::..|||.|.||...:|.|:|.|.|
Yeast   930 GHVSHIDFGFMLSNSP-GSVGFEAAPFKLTYEYIELLGG-VEGEAFKKFVELTKSSFKALRKYAD 992

  Fly  2085 AIVSLVSLM-LDTGLPCFRG--QTINLLKQRFVATKNNKEA---AAHMLAVIRNSYQNFRTRTYD 2143
            .|||:..:| .|...|||..  ||...|:|||....:.||.   ..:.|  |..|..:..||.||
Yeast   993 QIVSMCEIMQKDNMQPCFDAGEQTSVQLRQRFQLDLSEKEVDDFVENFL--IGKSLGSIYTRIYD 1055

  Fly  2144 MIQ 2146
            ..|
Yeast  1056 QFQ 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	75/427 (18%)
		PI4Ka	1600..1775	CDD:238443	41/210 (20%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	124/431 (29%)
PIK1	NP_014132.1	TEL1	<1..1066	CDD:227365	261/1173 (22%)