DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and TOR1

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_012600.1 Gene:TOR1 / 853529 SGDID:S000003827 Length:2470 Species:Saccharomyces cerevisiae


Alignment Length:2270 Identity:404/2270 - (17%)
Similarity:722/2270 - (31%) Gaps:879/2270 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   324 IQHLQTIFAVSK--KLLTKDTLEHLDEQASDIFSLHQIKGY-----CYKSFSETLNLVLVTLLRE 381
            ::::::.|::.:  :::....:||.|.:...:.:|...:.|     |.::...:||.|...|.:.
Yeast   572 LKNIKSRFSLVEFVRIVALSYIEHTDPRVRKLAALTSCEIYVKDNICKQTSLHSLNTVSEVLSKL 636

  Fly   382 LLQHQVDLPTPFTKDVQ-EFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMANAAC 445
            |   .:.:..|. :|:: |.:|.  ||...:.|..|.|..|                        
Yeast   637 L---AITIADPL-QDIRLEVLKN--LNPCFDPQLAQPDNLR------------------------ 671

  Fly   446 VDLLVWAIRDETVDVD----------------YNVPSLQNGLQFLLKK------------EADKL 482
              ||..|:.||:.::.                |.:||::..|..||.|            .|..|
Yeast   672 --LLFTALHDESFNIQSVAMELVGRLSSVNPAYVIPSIRKILLELLTKLKFSTSSREKEETASLL 734

  Fly   483 CGRL-SQK----------LNL---------------------ELS------HKIVM-DHMPLLM- 507
            |..: |.|          ||:                     |||      .||.: |..||:: 
Yeast   735 CTLIRSSKDVAKPYIEPLLNVLLPKFQDTSSTVASTALRTIGELSVVGGEDMKIYLKDLFPLIIK 799

  Fly   508 ------------VCLEGLGKLAHK----------FPNIAGTSISYL--------RDFLVAPSPIL 542
                        ..|:.||:||..          :|.:.|..::.|        |...|....||
Yeast   800 TFQDQSNSFKREAALKALGQLAASSGYVIDPLLDYPELLGILVNILKTENSQNIRRQTVTLIGIL 864

  Fly   543 GKLHDHAMQSLAQQKKEKELT------------PFKIAV-------QHSDSRTAVVIYGDNQKPP 588
            |.:..:       ::||:|:|            |..||:       .:.:..|.|||        
Yeast   865 GAIDPY-------RQKEREVTSTTDISTEQNAPPIDIALLMQGMSPSNDEYYTTVVI-------- 914

  Fly   589 GSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNRLFTAEKSGSESQGECHK 653
                    |...:.|:|.       :|.:.||       |::                 |...|.
Yeast   915 --------HCLLKILKDP-------SLSSYHT-------AVI-----------------QAIMHI 940

  Fly   654 SNLVSLNIIVMLGHVAVALKDTSKT-TQNILQFFIQRFCKVPSEQNALIVDQLGCMIISQCETHV 717
            ...:.|..:..|..:...:.|..:| :|::|:|:.|:.|       :||:      |:.|   |:
Yeast   941 FQTLGLKCVSFLDQIIPTILDVMRTCSQSLLEFYFQQLC-------SLII------IVRQ---HI 989

  Fly   718 FDEIMKMFSRVTVQSASLAYTSDPEHRKQFHHVSD---AVVNALGNIAANIQGDAEMLELLGKLL 779
            ...:..:|..:                |.|..|:.   .:|:.:..|:..::|  |...|:...|
Yeast   990 RPHVDSIFQAI----------------KDFSSVAKLQITLVSVIEAISKALEG--EFKRLVPLTL 1036

  Fly   780 ELFVQIGLDGERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRLPPIKNPRQRLHKLFKDF---- 840
            .||:.| |:.::|.|      |..||                          |:.:|.:.|    
Yeast  1037 TLFLVI-LENDKSSD------KVLSR--------------------------RVLRLLESFGPNL 1068

  Fly   841 --WAYCVVMGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVNELRSQ 903
              :::.:    |...:..|::..|..|.:|  .:.|.:.|...|:.|::..:         :.|.
Yeast  1069 EGYSHLI----TPKIVQMAEFTSGNLQRSA--IITIGKLAKDVDLFEMSSRI---------VHSL 1118

  Fly   904 ILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEM-------LRVENADEPSLEPIMSYLCDTAL 961
            :.||...:||.::..|..        .||:..::|       :.|.|      |.:|.       
Yeast  1119 LRVLSSTTSDELSKVIMN--------TLSLLLIQMGTSFAIFIPVIN------EVLMK------- 1162

  Fly   962 QRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSF 1026
                       |.:...:::...|.:..:|.:..|:||:..|        .:||.:.:       
Yeast  1163 -----------KHIQHTIYDDLTNRILNNDVLPTKILEANTT--------DYKPAEQM------- 1201

  Fly  1027 LVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLKDF 1091
                                               |.....|...|..                 
Yeast  1202 -----------------------------------EAADAGVAKLPIN----------------- 1214

  Fly  1092 ADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRP-- 1154
                |.::..|...:.:.|:...||:..::...:|......||   ...|:.|.....::|..  
Yeast  1215 ----QSVLKSAWNSSQQRTKEDWQEWSKRLSIQLLKESPSHAL---RACSNLASMYYPLAKELFN 1272

  Fly  1155 ---SCVNSDTPRFVSVLCLRSKYAGEISG---------------------LLSVLSEKDKA-GLA 1194
               :||.::         |.|:|..::.|                     |:..:...||| .:.
Yeast  1273 TAFACVWTE---------LYSQYQEDLIGSLCIALSSPLNPPEIHQTLLNLVEFMEHDDKALPIP 1328

  Fly  1195 DRLVSDVWEACAEKSDARHRGAL--------WRATAYLIICSEISRK------LLHAVASSQLEL 1245
            .:.:.:..|.|...:.|.|...:        ....:.:.|.:::::.      |.||.....|:|
Yeast  1329 TQSLGEYAERCHAYAKALHYKEIKFIKEPENSTIESLISINNQLNQTDAAIGILKHAQQHHSLQL 1393

  Fly  1246 FTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMG-------LFAWETEVTHPLAA 1303
             .|:..| .:|.|:..|.|..:.|        .|..|:....:|       |..||.  ...|||
Yeast  1394 -KETWFE-KLERWEDALHAYNERE--------KAGDTSVSVTLGKMRSLHALGEWEQ--LSQLAA 1446

  Fly  1304 --YEGCKLVSKPIL--IAPHLIW----LQLLSEMVDTAKYCNRDKVEMF--CLLLHRCLPVLKSS 1358
              ::..||.:|.::  :|....|    ..:|.:.:...|..:.|| |.|  .|.||      |:.
Yeast  1447 RKWKVSKLQTKKLIAPLAAGAAWGLGEWDMLEQYISVMKPKSPDK-EFFDAILYLH------KND 1504

  Fly  1359 KQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERI---YSNALDYFCGPPTCPNQSREQ 1420
            ..|.....:..| .||...:|.|...:..::.| .|:|.:|   :...:.|...||....:...|
Yeast  1505 YDNASKHILNAR-DLLVTEISALINESYNRAYS-VIVRTQIITEFEEIIKYKQLPPNSEKKLHYQ 1567

  Fly  1421 LL-----------------------------EDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNAS 1456
            .|                             :|:.|.:||....|..         |...|.|.:
Yeast  1568 NLWTKRLLGCQKNVDLWQRVLRVRSLVIKPKQDLQIWIKFANLCRKS---------GRMRLANKA 1623

  Fly  1457 VSSTQMLAVRNNPETAS--------------LISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSS 1507
            ::  .:|...|:|...:              .|...|...:....:....:.:...:|:...   
Yeast  1624 LN--MLLEGGNDPSLPNTFKAPPPVVYAQLKYIWATGAYKEALNHLIGFTSRLAHDLGLDPN--- 1683

  Fly  1508 SGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLI----TWYNPNS 1568
                |.|..|.. ||..|..         .|.::|.|   |:......:.|:.|    .|.|.| 
Yeast  1684 ----NMIAQSVK-LSSASTA---------PYVEEYTK---LLARCFLKQGEWRIATQPNWRNTN- 1730

  Fly  1569 LPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEII------------ 1621
             ||.|:......|.:....||          || :|.|||        |.|:|            
Yeast  1731 -PDAILGSYLLATHFDKNWYK----------AW-HNWALA--------NFEVISMVQEETKLNGG 1775

  Fly  1622 --DEEVSRLVCSDPIAV-----------------------CHIPEALKYLCTTKNLLQ------- 1654
              |::....|.:|.:.:                       .|:..|:|....:.:||:       
Yeast  1776 KNDDDDDTAVNNDNVRIDGSILGSGSLTINGNRYPLELIQRHVVPAIKGFFHSISLLETSCLQDT 1840

  Fly  1655 ---------------------ESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLS-- 1696
                                 |..:|:.|.:|..|.|    ...||.:...|..:...:..||  
Yeast  1841 LRLLTLLFNFGGIKEVSQAMYEGFNLMKIENWLEVLP----QLISRIHQPDPTVSNSLLSLLSDL 1901

  Fly  1697 --SYPAESVLPYIPQLVQALRHDTMG------YVVEFIKNIS----RRSQIVAHQLI-----WNM 1744
              ::|...|.|    |..|::.:::.      .::|.|:..|    .::::|:|:||     |: 
Yeast  1902 GKAHPQALVYP----LTVAIKSESVSRQKAALSIIEKIRIHSPVLVNQAELVSHELIRVAVLWH- 1961

  Fly  1745 QTNMYMD--EDQ------QHKDPNLYEALDQLSQ------------SIIASFSGAAKRFYE---- 1785
              .::.:  ||.      :|....::..|:.|.:            |...||.......||    
Yeast  1962 --ELWYEGLEDASRQFFVEHNIEKMFSTLEPLHKHLGNEPQTLSEVSFQKSFGRDLNDAYEWLNN 2024

  Fly  1786 ---------------REFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQ-GGCYLPSNPE 1834
                           ..::.|.|||....::::.  .::..:..|.|...:::. .|.|.|..|.
Yeast  2025 YKKSKDINNLNQAWDIYYNVFRKITRQIPQLQTL--DLQHVSPQLLATHDLELAVPGTYFPGKPT 2087

  Fly  1835 AMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAA 1899
            ..:...:     |:.|                :...:.|..:.|...:..:|.|..|        
Yeast  2088 IRIAKFE-----PLFS----------------VISSKQRPRKFSIKGSDGKDYKYVL-------- 2123

  Fly  1900 IFKVGDDVRQDMLALQ----VITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQL 1960
              |..:|:|||.|.:|    |.|:.||..:.....|.:..|..:..:|..|::..|||:.:...|
Yeast  2124 --KGHEDIRQDSLVMQLFGLVNTLLKNDSECFKRHLDIQQYPAIPLSPKSGLLGWVPNSDTFHVL 2186

  Fly  1961 GRQTDSGLS--------------------------EYFQHQYGD--------------ESSKEFQ 1985
            .|:......                          |.|.:...:              .||:.:.
Yeast  2187 IREHRDAKKIPLNIEHWVMLQMAPDYENLTLLQKIEVFTYALDNTKGQDLYKILWLKSRSSETWL 2251

  Fly  1986 AARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDK-DGHIIHIDFGFMFESSPGGNI--------- 2040
            ..|..:.:|:|..|:.||:|.:.|||..|:|:|: .|.:||||||..||::    |         
Yeast  2252 ERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHIDFGDCFEAA----ILREKYPEKV 2312

  Fly  2041 ---------------GFEPDMKLTDEMVM-IMGGKMDS-----------PAFKWFCELCVQAFLA 2078
                           |.|...::|.|.|| ::....:|           |...|..:|..|    
Yeast  2313 PFRLTRMLTYAMEVSGIEGSFRITCENVMRVLRDNKESLMAILEAFALDPLIHWGFDLPPQ---- 2373

  Fly  2079 VRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFR 2138
                        .|...||:|........||::..:..    |.||:|.|..:|..:|.|
Yeast  2374 ------------KLTEQTGIPLPLINPSELLRKGAITV----EEAANMEAEQQNETKNAR 2417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 47/278 (17%)
PI4Kc_III_alpha 1836..2153 CDD:270711 79/384 (21%)
TOR1NP_012600.1 TEL1 279..2470 CDD:227365 404/2270 (18%)
HEAT repeat 588..620 CDD:293787 6/31 (19%)
HEAT repeat 632..658 CDD:293787 7/31 (23%)
HEAT repeat 668..698 CDD:293787 7/55 (13%)
HEAT repeat 706..736 CDD:293787 7/29 (24%)
HEAT repeat 749..778 CDD:293787 2/28 (7%)
HEAT_EZ 771..820 CDD:290247 11/48 (23%)
HEAT repeat 792..827 CDD:293787 8/34 (24%)
DUF3385 827..986 CDD:288698 40/225 (18%)
Rapamycin_bind 1952..2049 CDD:285924 15/99 (15%)
PIKKc_TOR 2090..2366 CDD:270713 62/310 (20%)
FATC 2439..2470 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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