DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pi4KIIIalpha and PI-4KBETA2

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	NP_196497.1	Gene:	PI-4KBETA2 / 830794	AraportID:	AT5G09350	Length:	1116	Species:	Arabidopsis thaliana

Alignment Length:	699	Identity:	183/699 - (26%)
Similarity:	308/699 - (44%)	Gaps:	165/699 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1505 GSSSGWYNT------IPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFL--- 1560
            ||.....||      :|::|:.           |::|.||.:               .|||:
plant   522 GSPKPQNNTPSKKPPLPNNTAA-----------QFRKGSYHE---------------SLEFVHAL 560

  Fly  1561 -ITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAW-------CYNPALAVFLPQRIKN 1617
             .|.|:   |.| |.|.|::.|..|     .::....:.||.       |:.....|:....|..
plant   561 CETSYD---LVD-IFPIEDRKTALR-----ESIAEINSHLAQAETTGGICFPMGRGVYRVVNIPE 616

  Fly  1618 AEII----DEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFS 1678
            .|.:    .|:|..::|.: :.....|...|   ||...|:        ||...:......|:..
plant   617 DEYVLLNSREKVPYMICVE-VLKAETPCGAK---TTSTSLK--------LSKGGIPLANGDAFLH 669

  Fly  1679 RQYP-SHPL-TAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLI 1741
            :..| ::|| |||...:..:...:.|.:..|.   ||:.|               :|::......
plant   670 KPPPWAYPLSTAQEVYRNSADRMSLSTVEAID---QAMTH---------------KSEVKLVNAC 716

  Fly  1742 WNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFA- 1805
            .:::|         |.:.|        ::|:.:..:|..:...|.:.::...:......:|..:
plant   717 LSVET---------HSNSN--------TKSVSSGVTGVLRTGLESDLEWVRLVLTADPGLRMESI 764

  Fly  1806 -------KGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPM----QSAAKAPYLAR 1859
                   :...|:.:.:.|...::...     :..||       ..|.|:    |.::.|..:|.
plant   765 TDPKTPRRKEHRRVSSIVAYEEVRAAA-----AKGEA-------PPGLPLKGAGQDSSDAQPMAN 817

  Fly  1860 FRVYRCGIT---------ELETRAMEVSNNPNSQEDAKMTLGVESW--QAAIFKVGDDVRQDMLA 1913
            ..:.:.|..         .|..|...:..|            :..|  ::.|.|.|||.||:.||
plant   818 GGMLKAGDALSGEFWEGKRLRIRKDSIYGN------------LPGWDLRSIIVKSGDDCRQEHLA 870

  Fly  1914 LQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQ--TDSGLSEYFQHQY 1976
            :|:|:.|.:|||:.||.|:|.||.|:.|:....:||.:|:..|...:..:  ..:.|.::|..::
plant   871 VQLISHFFDIFQEAGLPLWLRPYEVLVTSSYTALIETIPDTASIHSIKSRYPNITSLRDFFDAKF 935

  Fly  1977 GDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIG 2041
             .|:|..|:.|:.|||:|||.|||:.||||||||||||:::|::|||||||||||..:|||| :.
plant   936 -KENSPSFKLAQRNFVESMAGYSLVCYLLQIKDRHNGNLLMDEEGHIIHIDFGFMLSNSPGG-VN 998

  Fly  2042 FE-PDMKLTDEMVMIMGGK---MDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFR 2102
            || ...|||.|::.:|...   :.|..|.:|..||:|.||..|.:.:.|:.||.::.|:|.|||:
plant   999 FESAPFKLTRELLEVMDSDAEGLPSEFFDYFKVLCIQGFLTCRKHAERIILLVEMLQDSGFPCFK 1063

  Fly  2103 G--QTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQ 2149
            |  :||..|::||..:...::..:.:|::|.:|...:|||.||   |||
plant  1064 GGPRTIQNLRKRFHLSLTEEQCVSLVLSLISSSLDAWRTRQYD---YYQ 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	32/187 (17%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	121/337 (36%)
PI-4KBETA2	NP_196497.1	BMS1	<240..>405	CDD:227519
PI-4KBETA2	NP_196497.1	PI4Kc_III_beta	826..1115	CDD:270712	115/301 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820