DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and TRRAP

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_001362453.1 Gene:TRRAP / 8295 HGNCID:12347 Length:3873 Species:Homo sapiens


Alignment Length:2574 Identity:454/2574 - (17%)
Similarity:804/2574 - (31%) Gaps:940/2574 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   313 PRPLYRVPPFPIQHLQTIFAVSKKLLTKD------TLEHLDEQASDIFSLHQIKGYCYKSFSETL 371
            ||.|..:....:|.||...|...:.|..:      |.|||.....::.|:       ...|.||.
Human    67 PRFLTFLQDGEVQFLQEKPAQQLRKLVLEIIHRIPTNEHLRPHTKNVLSV-------MFRFLETE 124

  Fly   372 N----LVLVTLLREL-----------LQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNK------ 415
            |    |:.:.::.||           :.|.:|......|::.:.|.|.|.|.|...:|.      
Human   125 NEENVLICLRIIIELHKQFRPPITQEIHHFLDFVKQIYKELPKVVNRYFENPQVIPENTVPPPEM 189

  Fly   416 ---------QQDQERERREENGIAVV--NKYKVNVMANAACVDLLVWAIRD--------ETVDVD 461
                     :.:.|||..|....:::  ....:.|:|....:.:|::.:..        |.|.:.
Human   190 VGMITTIAVKVNPEREDSETRTHSIIPRGSLSLKVLAELPIIVVLMYQLYKLNIHNVVAEFVPLI 254

  Fly   462 YNVPSLQNGLQF----LLKKE--ADKLCG------------RLSQKLNLELSHKIVMDHMPLLMV 508
            .|..::|...|.    |..||  ||.:..            |:.|:|..:.|.::|...:.||..
Human   255 MNTIAIQVSAQARQHKLYNKELYADFIAAQIKTLSFLAYIIRIYQELVTKYSQQMVKGMLQLLSN 319

  Fly   509 CLEGLGKLAH--KFPNIAGTSI--SYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAV 569
            |   ..:.||  |...||...|  :.||:..:   |.:.||.|.::...:.....:.|.|...:.
Human   320 C---PAETAHLRKELLIAAKHILTTELRNQFI---PCMDKLFDESILIGSGYTARETLRPLAYST 378

  Fly   570 ---------QH---SDSRTAVVIYG---DNQKPPGS-------------------GTGRSGHAAF 600
                     ||   ||...||.::.   |::..|.|                   ....||:.  
Human   379 LADLVHHVRQHLPLSDLSLAVQLFAKNIDDESLPSSIQTMSCKLLLNLVDCIRSKSEQESGNG-- 441

  Fly   601 ESLRDAAIENLSIALRAAHTLDQF--------CVP--------ALVANV---------------- 633
               ||..:..|.:.:...||:.::        |.|        |.:..|                
Human   442 ---RDVLMRMLEVFVLKFHTIARYQLSAIFKKCKPQSELGAVEAALPGVPTAPAAPGPAPSPAPV 503

  Fly   634 ------------SNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFF 686
                        :..:..|.....|.|||..|.:..:..:......|...:......|..|..  
Human   504 PAPPPPPPPPPPATPVTPAPVPPFEKQGEKDKEDKQTFQVTDCRSLVKTLVCGVKTITWGITS-- 566

  Fly   687 IQRFCKVPSE------------------------QNALIVDQLGC-------MIISQCET----- 715
                ||.|.|                        ..||.:.|:..       :.::.|:|     
Human   567 ----CKAPGEAQFIPNKQLQPKETQIYIKLVKYAMQALDIYQVQIAGNGQTYIRVANCQTVRMKE 627

  Fly   716 ------H-----------VFDEIMK-----MFSRVT----VQSASLAYTSDPEHRKQFHHV-SDA 753
                  |           .|.||.:     |..|::    :|..:.::.::|.....|..: .:.
Human   628 EKEVLEHFAGVFTMMNPLTFKEIFQTTVPYMVERISKNYALQIVANSFLANPTTSALFATILVEY 692

  Fly   754 VVNALGNIAANIQGDAEMLELLGKLLEL-FVQIGLDGERSYDNTPGAQKASSRAGNLGMLIPVIA 817
            :::.|..:.:|:    |:..|..||.:| |..:.|                ..|.|..||.|   
Human   693 LLDRLPEMGSNV----ELSNLYLKLFKLVFGSVSL----------------FAAENEQMLKP--- 734

  Fly   818 VLVRRLPPIKNPRQRLHKLFKDFWAYCVVM--------GFTNARLWP------ADWYQGVQQIAA 868
                .|..|.|....|.:..|:.:.|.:::        |.::..|:.      .:..||:.    
Human   735 ----HLHKIVNSSMELAQTAKEPYNYFLLLRALFRSIGGGSHDLLYQEFLPLLPNLLQGLN---- 791

  Fly   869 KSPLLISQTAHKSDMRELNYTLAIKSDSVNELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSV 933
                ::....||..|::|...|.:   :|....|.:|..|....|.:.:|:|.   :|......:
Human   792 ----MLQSGLHKQHMKDLFVELCL---TVPVRLSSLLPYLPMLMDPLVSALNG---SQTLVSQGL 846

  Fly   934 YWLEMLRVENADEPS-----LEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKF----RNVLYA 989
            ..|| |.|:|. :|.     ::|:.:.|.. ||.|........:..||.:|..||    |.:|..
Human   847 RTLE-LCVDNL-QPDFLYDHIQPVRAELMQ-ALWRTLRNPADSISHVAYRVLGKFGGSNRKMLKE 908

  Fly   990 HDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRF------PHLLWNRRVLW----CM 1044
            ..::...|.|.|...:.|.|:.....:|:..::.:...:|..      |:.   ||..|    |.
Human   909 SQKLHYVVTEVQGPSITVEFSDCKASLQLPMEKAIETALDCLKSANTEPYY---RRQAWEVIKCF 970

  Fly  1045 LDILQLL------AYSLSLDPN--EETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNE 1101
            |..:..|      .|.|...||  |:|....::|..|..|   ..|||    |.|.   |.:...
Human   971 LVAMMSLEDNKHALYQLLAHPNFTEKTIPNVIISHRYKAQ---DTPAR----KTFE---QALTGA 1025

  Fly  1102 AMKWAPRSTRSHLQEYPNQIP--TPVLAHHSGLALA------------FDSVVSSSAQHTGTMSK 1152
            .|....:..|      |:.:|  ..::.|::.:|:|            ..|..|::..|    |:
Human  1026 FMSAVIKDLR------PSALPFVASLIRHYTMVAVAQQCGPFLLPCYQVGSQPSTAMFH----SE 1080

  Fly  1153 RPSCVNSDTPRFVSVLCLRSKY-------AGEISGLLSV--------LSEKDKA---GLADRLVS 1199
            .......|....:..:.:...|       .||::  |:|        |..|::|   .|...:|.
Human  1081 ENGSKGMDPLVLIDAIAICMAYEEKELCKIGEVA--LAVIFDVASIILGSKERACQLPLFSYIVE 1143

  Fly  1200 DVWEACAEKSDARHRGAL-------------W---------RATAYLI--ICSEISRKLLHAVAS 1240
            .:...|.|::.....|.:             |         :|..:::  :..|:|...: |:|.
Human  1144 RLCACCYEQAWYAKLGGVVSIKFLMERLPLTWVLQNQQTFLKALLFVMMDLTGEVSNGAV-AMAK 1207

  Fly  1241 SQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLA--- 1302
            :.||       :..:.|    .|..:|.|..  :|:|:|.:.:|.          .|||.|.   
Human  1208 TTLE-------QLLMRC----ATPLKDEERA--EEIVAAQEKSFH----------HVTHDLVREV 1249

  Fly  1303 ----------AYEGCKLV------SKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRC 1351
                      |....:::      |..:::.||   .::|.:||...|:                
Human  1250 TSPNSTVRKQAMHSLQVLAQVTGKSVTVIMEPH---KEVLQDMVPPKKH---------------- 1295

  Fly  1352 LPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTI-----PK--SLSRNILRERIYSNALDYFCG 1409
              :|:....|.|:              .|::|||.     |:  ::..|::..:::...|...|.
Human  1296 --LLRHQPANAQI--------------GLMEGNTFCTTLQPRLFTMDLNVVEHKVFYTELLNLCE 1344

  Fly  1410 ---------------PPTCP---------------NQSREQLLEDIMILLKFWQTMRSE------ 1438
                           |...|               .||||::   |..|.|...:..||      
Human  1345 AEDSALTKLPCYKSLPSLVPLRIAALNALAACNYLPQSREKI---IAALFKALNSTNSELQEAGE 1406

  Fly  1439 ---KKHL--VTSEV--------------GDY-----DLTNASVSSTQ--------------MLAV 1465
               :|.|  .|.||              |||     ::.|...|.|:              |..:
Human  1407 ACMRKFLEGATIEVDQIHTHMRPLLMMLGDYRSLTLNVVNRLTSVTRLFPNSFNDKFCDQMMQHL 1471

  Fly  1466 RNNPETASLISGGGLVNDYTRSMSASGNA------------VGM-GMGVAGGGSSSGWYNTIPHS 1517
            |...|...:...||..:|...|:|..|..            .|: .|.:.  .:....::.||.:
Human  1472 RKWMEVVVITHKGGQRSDGNESISECGRCPLSPFCQFEPAMEGVEEMKIC--SAIINLFHLIPAA 1534

  Fly  1518 TSTLSK-------RSNRSKRLQYQ---KDSYDKDYMKKRNLILELLAVE------------LEFL 1560
            ..||.|       ::.|:..::..   ::...|...:..:..:||..:|            :.||
Human  1535 PQTLVKPLLEVVMKTERAMLIEAGSPFREPLIKFLTRHPSQTVELFMMEATLNDPQWSRMFMSFL 1599

  Fly  1561 ----------ITWYNPNSLPDLIVPGEEQITEWRNRPYKSTV----------------------- 1592
                      :...|||....|::||..|.......|..||:                       
Human  1600 KHKDARPLRDVLAANPNRFITLLLPGGAQTAVRPGSPSTSTMRLDLQFQAIKIISIIVKNDDSWL 1664

  Fly  1593 --------------------------------WRDYARLAWC--------YN------PALAVFL 1611
                                            |::...||:|        |.      ..|..|.
Human  1665 ASQHSLVSQLRRVWVSENFQERHRKENMAATNWKEPKLLAYCLLNYCKRNYGDIELLFQLLRAFT 1729

  Fly  1612 PQRIKN----AEIIDEEVSR--------------LVCSDP--------IAVCHI----------- 1639
            .:.:.|    .|.::||:.:              :..:||        ..:.||           
Human  1730 GRFLCNMTFLKEYMEEEIPKNYSIAQKRALFFRFVDFNDPNFGDELKAKVLQHILNPAFLYSFEK 1794

  Fly  1640 ----------------PEALKYLCTTKNL-LQESPDL-----VYILSWSPV-------------- 1668
                            ||::..:..||.| .::..|:     :|:|.::.:              
Human  1795 GEGEQLLGPPNPEGDNPESITSVFITKVLDPEKQADMLDSLRIYLLQYATLLVEHAPHHIHDNNK 1859

  Fly  1669 ---TPIQALAYF-------------SRQYPSHPLTAQYAVK--------------TLSSYPAES- 1702
               :.::.|..|             :.:|..|.|.|....|              .|.::..|: 
Human  1860 NRNSKLRRLMTFAWPCLLSKACVDPACKYSGHLLLAHIIAKFAIHKKIVLQVFHSLLKAHAMEAR 1924

  Fly  1703 ---------VLPYIPQLV----QALRHDTMGYVVEFIKNISRRSQI-------------VAHQLI 1741
                     :.|.:|..:    |.|.|.|...:||....:.:...|             |.|.|:
Human  1925 AIVRQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGHTVPQLVHILHLIVQHFKVYYPVRHHLV 1989

  Fly  1742 WNM----------------QTNMYMD-------------EDQQ---HKDPNLY-EALDQLSQSII 1773
            .:|                |..:.:|             :|||   ..|||.. |.::.:|.||.
Human  1990 QHMVSAMQRLGFTPSVTIEQRRLAVDLSEVVIKWELQRIKDQQPDSDMDPNSSGEGVNSVSSSIK 2054

  Fly  1774 ASFSGAAKRFYEREFDFFGKITAVSGEIRS-------FAKGIERKNACLAALSRIKVQGGCYLPS 1831
            ...|..:.:..:|.....|.|:||.|..:|       .||.|::::........|:|  .|.:..
Human  2055 RGLSVDSAQEVKRFRTATGAISAVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRV--ACQVND 2117

  Fly  1832 NPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESW 1896
            |..        ::|:|.:..::          ||      ...::.:..|:....:::.|   .|
Human  2118 NTN--------TAGSPGEVLSR----------RC------VNLLKTALRPDMWPKSELKL---QW 2155

  Fly  1897 QAAIFKVGDDVRQ-----DMLALQVITIFKNIFQQVG-LDLFLFPYRVVATAPGCG---VIECVP 1952
            ...:....:...|     ....|:|::....:.|... |..|....|.:|....||   |:..|.
Human  2156 FDKLLMTVEQPNQVNYGNICTGLEVLSFLLTVLQSPAILSSFKPLQRGIAACMTCGNTKVLRAVH 2220

  Fly  1953 NAKSR----DQLGRQTDSGLSEYFQHQ--YGDESSKEFQAARANFVKSMAA--YSLIGYLLQIKD 2009
            :..||    ......|.|..|:|.:.:  |. ...|.......|:.|:..|  ..|.|.|:.:|.
Human  2221 SLLSRLMSIFPTEPSTSSVASKYEELECLYA-AVGKVIYEGLTNYEKATNANPSQLFGTLMILKS 2284

  Fly  2010 RHNGN-IMIDKDGHIIHIDFGFM--------FESSPGGNIGFEPDMKLTDEMVM----------- 2054
            ..:.| ..||:   :|.:   ||        ...:|....|.......|.|:||           
Human  2285 ACSNNPSYIDR---LISV---FMRSLQKMVREHLNPQAASGSTEATSGTSELVMLSLELVKTRLA 2343

  Fly  2055 IMGGKMDSPAFKWFCELCVQAFLAVRP---YQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVAT 2116
            :|..:|.    |.|.:..:.:.:...|   ...|:|.:|...:....|....||..|.::..:..
Human  2344 VMSMEMR----KNFIQAILTSLIEKSPDAKILRAVVKIVEEWVKNNSPMAANQTPTLREKSILLV 2404

  Fly  2117 KNNKEAAAHMLAVIRNSYQ---NFRTRTYDMIQY-YQNQ 2151
            |        |:..|...:.   ....:..|::.| |:::
Human  2405 K--------MMTYIEKRFPEDLELNAQFLDLVNYVYRDE 2435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 55/351 (16%)
PI4Kc_III_alpha 1836..2153 CDD:270711 64/360 (18%)
TRRAPNP_001362453.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..541 6/49 (12%)
Interaction with TP53. /evidence=ECO:0000269|PubMed:12138177 2017..2395 82/417 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2030..2051 7/20 (35%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2054..2069 2/14 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2550..2585
TEL1 <2552..3873 CDD:227365
FAT 2868..3200 CDD:367004
PIKK_TRRAP 3510..3797 CDD:270707
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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