Protein Alignment Pi4KIIIalpha and Pi4kb

DIOPT Version :10

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: XP_038959158.1
• Gene: Pi4kb / 81747
• RGDID: 621214
• Length: 862
• Species: Rattus norvegicus
• Alignment Length: 888
• Identity: 208/888 - (23%)
• Similarity: 342/888 - (38%)
• Gaps: 260/888 - (29%)

  Fly  1442 LVTSEVGDYDLTNASVSSTQM-------------LAVRNNPETASLISGGGLVNDYTRSMSASGN 1493
            ::|..||:..:.:..|:....             :|:.:......|::|.|:.|: .|.:.....
  Rat    57 VITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAISSKGSPLELVNGDGVDNE-IRCLDDPPT 120

  Fly  1494 AV-----GMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILEL- 1552
            .:     .|..||..|.:.           .|..:|.|.|               .|::.:|.|
  Rat   121 EIREEEDEMEPGVVSGTAK-----------GTRRRRQNNS---------------AKQSWLLRLF 159

  Fly  1553 ------LAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCY-NPALAVF 1610
                  :::.:.:|   ||...      ||.:...  .||             .:|: |..:..:
  Rat   160 ESKLFDISMAISYL---YNSKE------PGVQAYI--GNR-------------LFCFRNEDVDFY 200

  Fly  1611 LPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILS--WSPVTPIQA 1673
            |||.:.....:||:|...:  .|..|....:::.:......||......::|.:  .|..|.::.
  Rat   201 LPQLLNMYIHMDEDVGDAI--KPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRK 263

  Fly  1674 LAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAH 1738
            |.......|:|   .:..:.|||..|...:.|                    .|...:||:..|.
  Rat   264 LILSDELKPAH---RKRELPTLSPAPDTGLSP--------------------SKRTHQRSKSDAT 305

  Fly  1739 QLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRS 1803
            ..| ::.:|:....... |..|..|.|...::||..|||...:...|||  |...:.|:...:.:
  Rat   306 ASI-SLSSNLKRTASNP-KVENEDEELSSSTESIDNSFSSPVRLAPERE--FIKSLMAIGKRLAT 366

  Fly  1804 FAKGIERKNACLAALSRI--KVQGGCYLP-SNPEAMVLDIDYSSGTPMQSAAKAPYLA------- 1858
            .....::....::.||.:  |:....:|| :..:..|:.:.::....:.|..|||||.
  Rat   367 LPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLEC 431

  Fly  1859 ---------------RFRVYR-------CGITELETRAMEVSNNPN------------------- 1882
                           |.|..|       ||||. |.||...|..||
  Rat   432 ENFDTTNVPARIPENRIRSTRSVENLPECGITH-EQRAGSFSTVPNYDNDDEAWSVDDIGELQVE 495

  Fly  1883 ---------------------SQE----------DAKMTLG----------------------VE 1894
                                 |||          |.:..|.                      .|
  Rat   496 LPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKE 560

  Fly  1895 SWQ---------------------AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRV 1938
            .||                     :.|.|.|||:||::||.||:...::|::|..:.|::.||::
  Rat   561 PWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI 625

  Fly  1939 VATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGY 2003
            :..:...|:||.|.||.|..|:.:|:...|.:||..::|..:::.|.:|:.|||:|.|.|.|:.|
  Rat   626 LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCY 690

  Fly  2004 LLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPD-MKLTDEMVMIMGGKMDSPAFKW 2067
            |||:||||||||::|.:||||||||||:..||| .|:|||.. .|||.|.|.:||| ::...|.:
  Rat   691 LLQVKDRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LNGDMFNY 753

  Fly  2068 FCELCVQAFLAVRPYQDAIVSLVSLM----------------------LDTGLPCFRG-QTINLL 2109
            :..|.:|..:|.|.:.|.:|.:|.:|                      :.:.||||.| .||..|
  Rat   754 YKMLMLQGLIAARKHMDKVVQIVEIMQQGCRRCSGASLSGPVVTVAQVICSQLPCFHGSSTIRNL 818

  Fly  2110 KQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQI 2152
            |:||..:...::....:..::..|.::..|:.||..||..|.|
  Rat   819 KERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGI 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	24/153 (16%)
		PI4Ka	1600..1775	CDD:238443	35/177 (20%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	132/463 (29%)
Pi4kb	XP_038959158.1	PI4KB_NTD	27..91	CDD:412074	4/33 (12%)
		PI4Kc_III_beta	554..862	CDD:270712	107/310 (35%)