Protein Alignment Pi4KIIIalpha and Pi4ka

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: XP_008767124.1
• Gene: Pi4ka / 64161
• RGDID: 621213
• Length: 2114
• Species: Rattus norvegicus
• Alignment Length: 2219
• Identity: 990/2219 - (44%)
• Similarity: 1358/2219 - (61%)
• Gaps: 222/2219 - (10%)

  Fly    11 YQRTVLCLARVLAGIQPTPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEG 75
            |..|||.|||.||..:|...:|||.|...||.: ..|:|.||.|.:||||||||:.:|...||:.
  Rat    43 YFNTVLSLARSLAVQRPASLEKVQKLLCMCPVD-FHGIFQLDERRRDAVIALGIFLIESDLQHKD 106

  Fly    76 QIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAAKCPDSREEIILNQV 140
            .||||||||.:.|||..|::::.:.| .|..:|.||.|||||.|||||:|.:.|..|:||:...:
  Rat   107 CIVPYLLRLLRGLPKVYWVEESTARK-GRGNLPVAESFSFCLVTLLSDVACRDPSLRDEILEALL 170

  Fly   141 ETLSALANIVKSSRDSSSAPPPIILCKATVPLLFGLARSMGRYASNDPPLLCRIF---PPELLPI 202
            :.|..|..:.::.......    .|||..:|.|.|::||.|||::::..||.::|   ||..|.|
  Rat   171 QVLHVLLGMCQALEIQEKE----YLCKYAIPCLIGISRSFGRYSNSEESLLSKLFPKVPPHSLRI 231

  Fly   203 QKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSM------------SGSLAQAQNA 255
            .:           ...|....||:.         ||.|:|.::            :.|::.....
  Rat   232 PE-----------ELEGVRRRSFND---------FRSILPSNLLTVCQEGTLKRKTSSVSSISQV 276

  Fly   256 SYDDGRQRCAGGKPSKP--SLHSYFSVPYDP------RTHFFTRYGSSFNQFPNMRVCESPTKGG 312
            |.:.|..     .||.|  |...||.....|      ..::|:...|||:        .||...|
  Rat   277 SPERGMP-----PPSSPGGSAFHYFEASCLPDGTTLEPEYYFSTISSSFS--------VSPLFNG 328

  Fly   313 PRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVT 377
              ..|:....|::.|:.:..:.||::.:..|:.||...:.:...:......|.:||:.:.|.:..
  Rat   329 --ITYKEFYIPLEMLRELLNLVKKIVEEPVLKSLDAAVARVMEANPSADLYYTTFSDPVYLTMFK 391

  Fly   378 LLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMAN 442
            :||:.|.:..||||.|.|::.:||...|...|.|||....|.:|...|      ::..|:...||
  Rat   392 MLRDTLYYMKDLPTSFVKEIHDFVLEQFNMSQGELQKILHDADRIHSE------MSPLKLRCQAN 450

  Fly   443 AACVDLLVWAIRDETVDVDYNVPSLQNGLQFLLKKEADKLCGRLSQKLNLELSHKIVMDHMPLLM 507
            ||||||:|||::||                    :.|:.||.:||:||..:.|.|:::.|:|||:
  Rat   451 AACVDLMVWAVKDE--------------------QGAENLCIKLSEKLQSKTSSKVIIAHLPLLI 495

  Fly   508 VCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGKLHDHAMQ--SLAQQKKEKELTPFKIAV- 569
            .||:|||:|..:||.:..:....||||||.|||:|.||:.:..|  ::|.       :..||:|
  Rat   496 CCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAG-------SDIKISVT 553

  Fly   570 -QHSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANV 633
             :||:| |..|:.|...:|          :.:|.|||.||:|:...|:|..|:|...|.|.:|::
  Rat   554 NEHSES-TLNVLPGKKNQP----------SMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASL 607

  Fly   634 SNRLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQN 698
            ||||:.:::|..:       ::|:..:.|..|||:||||:||.|..:.|||...|:||:.||..:
  Rat   608 SNRLYISQESDKD-------AHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLD 665

  Fly   699 ALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQ-FHHVSDAVVNALGNIA 762
            .||:|||||::|:. ..:::.|:..:|.:::|:::|:.|::..:::.. :.|.|.||:|||.|||
  Rat   666 VLIIDQLGCLVITG-NQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIA 729

  Fly   763 ANIQGDAEMLELLGKLLELFVQIGLDG----ERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRL 823
            ||||.:..:.|||..|||||||:||:|    ||:.:..| |.||||.|||||:||||||||.|||
  Rat   730 ANIQEEHLVDELLMNLLELFVQLGLEGKRASERASEKGP-ALKASSSAGNLGVLIPVIAVLTRRL 793

  Fly   824 PPIKNPRQRLHKLFKDFWAYCVVMGFT--NARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRE- 885
            ||||..:.||.|||:|||.|.|:|||.  .:.|||.:||:||.:||.|||||...:  |..:|.
  Rat   794 PPIKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPS--KEPLRSV 856

  Fly   886 LNYTLAIKSDSV-----NELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENAD 945
            |.|..|:|:|:|     |||||.|:.||:...: |:..||||.||..|||||||.||.:||..:.
  Rat   857 LQYNSAMKNDTVTPAELNELRSTIINLLDPPPE-VSALINKLDFAMSTYLLSVYRLEYMRVLRST 920

  Fly   946 EPSLEPIM-SYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVL--YAHDEIREKVLESQATLLLV 1007
            :|....:| .|..|.|:|:||:|:.|||..|||:||:.|.|::  .|..:..|:.||..|..|||
  Rat   921 DPDRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMAEKAKTKENEEELERHAQFLLV 985

  Fly  1008 YFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTP 1072
            .||||||.|:.|||:|||.|||:||||||:..||..||||||.|:.|||.|.:::.|...:...|
  Rat   986 NFNHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAP 1050

  Fly  1073 YTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPV--LAHHSGLALA 1135
            |.:.:.|:..|||..:||||.||..|:.|||||||..|:||||||.|:....|  |:.|:|||:|
  Rat  1051 YRITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMA 1115

  Fly  1136 FDSVV---SSSAQHT----GTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLL------SVLSE 1187
            .:|::   ..:.|:|    ..:::||:||..|...|::.|.||::||||:.|::      ..:|:
  Rat  1116 TESILHFAGYNKQNTTLGVTQLTERPACVKKDYSNFMASLNLRNRYAGEVHGMIRFSGATGQMSD 1180

  Fly  1188 KDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAME 1252
            .:|     .:|.|:..|........:..|:::.||.||...:...:|||.:....|.:|.|..||
  Rat  1181 LNK-----MMVQDLITALDHSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGME 1240

  Fly  1253 TAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIA 1317
            ||:.||:|:|..:..:|:.|::||..||..|.|::.|||:.||:...||||.|..:....|..:.
  Rat  1241 TALACWEWLLAGKNGVEVPFMREMAGAWHMTVEQKFGLFSAETKEADPLAASEASQPRPCPPEVT 1305

  Fly  1318 PHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVL---KSSKQNRQVSTVGCRFKLLQCGLS 1379
            ||.||:..|.:..:.||||:.|:||:|..||.|.:.:.   .....||.|:.:|.|||||..|||
  Rat  1306 PHYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLHIGGARGSMNRHVAAIGPRFKLLTLGLS 1370

  Fly  1380 LLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVT 1444
            ||..:.:|.:..||:|||:|||.|.|||..||..|.|..::|.|||.|::|||..|.|:||:|..
  Rat  1371 LLHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTA 1435

  Fly  1445 SEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGG---S 1506
            |::...|                              |..|||          .:.:..|.   :
  Rat  1436 SQLVPPD------------------------------NQDTRS----------NLDITVGSRQQA 1460

  Fly  1507 SSGWYNTIPHST--STLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSL 1569
            :.||.||.|.|:  ||:||:|..||:.. :.....|.|||:|.|:|.|||.|:|.|||||||.|.
  Rat  1461 TQGWINTYPLSSGMSTISKKSGMSKKTN-RGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSA 1524

  Fly  1570 PDLIV--PGEEQITEWRNR--PYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVC 1630
            |:|.:  .||..:..||::  ......|:|...|||..:|.|||.||.|.||.|.|..||:|||.
  Rat  1525 PELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWTISPYLAVQLPARFKNTEAIGNEVTRLVR 1589

  Fly  1631 SDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTL 1695
            .||.||..:|||:|:|.|...:..::|:|.::|.|:|..|...|:|||..||.|||||||.||.|
  Rat  1590 LDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVL 1654

  Fly  1696 SSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPN 1760
            .|:|.:::|.||||:|||||:|.||||.|:|...:.:||::|||.||||:||:|:||:...|||:
  Rat  1655 RSFPPDAILFYIPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKTNIYLDEEGHQKDPD 1719

  Fly  1761 LYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQG 1825
            :.:.|:||.:.|..|.||.||.||:||||||.|||.||..|:.:.||.|||.|||:|||.:|||.
  Rat  1720 IGDLLEQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQP 1784

  Fly  1826 GCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNP-----NSQE 1885
            ||||||||||:||||||.|||||||||||||||:|:|.|||::|||...::..::.     ..:.
  Rat  1785 GCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDTEDECRRQEA 1849

  Fly  1886 DAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIEC 1950
            |.|..    .|||||||||||.||||||||:|.:||||||.||||||:|||||||||||||||||
  Rat  1850 DGKKI----CWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIEC 1910

  Fly  1951 VPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNI 2015
            :|:..||||||||||.|:.:||..||||||:..||.||.||::|||||||:.:||||||||||||
  Rat  1911 IPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNI 1975

  Fly  2016 MIDKDGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVR 2080
            |:||.|||||||||||||||||||:|:|||:||||||||||||||::..||||.|:||:.:||||
  Rat  1976 MLDKKGHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVR 2040

  Fly  2081 PYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMI 2145
            ||.||:||||:|||||||||||||||.|||.||......:|||..::.:|:|.:.:.|:||||||
  Rat  2041 PYMDAVVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKIIQNCFLSNRSRTYDMI 2105

  Fly  2146 QYYQNQIPY 2154
            |||||.|||
  Rat  2106 QYYQNDIPY 2114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	90/174 (52%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	221/321 (69%)
Pi4ka	XP_008767124.1	PI4Ka	1559..1734	CDD:238443	90/174 (52%)
		PI4Kc_III_alpha	1795..2113	CDD:270711	221/321 (69%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337223
Domainoid	1	1.000	1006	1.000	Domainoid score	I26
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11171
Inparanoid	1	1.050	1678	1.000	Inparanoid score	I71
OMA	1	1.010	-	-		QHG60094
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	1	1.000	-	-		FOG0002854
OrthoInspector	1	1.000	-	-		oto97313
orthoMCL	1	0.900	-	-		OOG6_101741
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2686
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910