DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and pik3c2a

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:XP_005159362.2 Gene:pik3c2a / 571356 ZFINID:ZDB-GENE-030328-39 Length:1691 Species:Danio rerio


Alignment Length:1300 Identity:286/1300 - (22%)
Similarity:488/1300 - (37%) Gaps:348/1300 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly  1055 LSLDP--------NEETPTLRVVSTPYTLQLMDSLPARELRLKD-----------FADRCQG--- 1097
            |.|||        .||||.  |.|.|:..:...:....:..|:|           ..::|:.   
Zfish   263 LDLDPLNKRKEVEVEETPA--VSSCPFIEESGKAKDPWDAVLQDEHETVDNGSPKAEEKCKATQP 325

  Fly  1098 ---------IVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGL---------ALAFDSVVSSSA 1144
                     ..::::..:..||.....:..|:..|.||:.:|.|         .:||...:|.  
Zfish   326 RRASTGAAVTKSQSLSISSNSTNQSTGKQVNKGSTNVLSKYSALQEKEAQNLEVVAFCEDISK-- 388

  Fly  1145 QHTGTMSKRPSCVNSDTPRFV-SVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEK 1208
                ..||.|....|..|.:| |.:..:....|:..|.:.|..|          :||..:.....
Zfish   389 ----LRSKFPHDDLSTNPGYVLSPVITQRDAGGDNGGSVKVSIE----------ISDSQQPVTFT 439

  Fly  1209 SDARH-------RGALW--------RATAYLI-ICSE---ISRKLLHAVASSQLELFTESAMETA 1254
            .|...       :...|        ...:|:: :|.:   :..|  |::.|.          |..
Zfish   440 CDVTSPVDLLIMQALCWVHDDLNQVDINSYVLKVCGQEEVLQNK--HSLGSH----------EYV 492

  Fly  1255 VECWQWVLTARQDLELCFIQEMVSAWQTT---------FEKRMGLF--AWETEVTHP-LAAY-EG 1306
            ..|.:|  .:...|:|.|:..|......|         .||.:||.  .::..||.. ||.| ||
Zfish   493 QNCRKW--ESEIKLQLLFLSTMRRDLARTAEDDISPIDLEKYLGLVERPFKEAVTREGLAEYLEG 555

  Fly  1307 C-KLVSKPILIAPHLIWLQ-------LLSEMVDTAK--YCNRDKVEMFCLLLHRCLPVLKSS--K 1359
            . |.|:         :.||       .:..:|.:.|  .|..|:||         .|.:..:  :
Zfish   556 FHKQVN---------LCLQNENNQYKTVDNVVQSVKNLCCALDEVE---------TPAITDAVKR 602

  Fly  1360 QNRQVSTVGCR----FKLLQCGLS----LLQGNTIPKSLSRNILRERIYSNA---LDYFCGPPTC 1413
            ..|.|:....|    :..||.|.:    ...|.:.|...|..:|.:.:|..|   |..||  |..
Zfish   603 LKRSVNLPRTRSPEHYAELQAGATSSGGSANGYSSPVEESLAVLTDAVYELAKLYLQSFC--PIS 665

  Fly  1414 PNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGG 1478
            |....|:..||          .|..|:...|:|...:.|          .||...|  |:.:|. 
Zfish   666 PGFMIEEHKED----------ERDSKEASGTTEHLQFTL----------FAVHGIP--ATWVSS- 707

  Fly  1479 GLVNDYTRSMSASGNAVGMGMGVAG---GGSSSGWYN-------TIPHSTSTLSKRSNRSKRL-- 1531
              ...|....:.:.|...:...|..   |...|.:|:       ..|.|.|.|...:..|..|  
Zfish   708 --FEKYYLMCALTHNNRNLFKPVQSKKVGTYKSFFYHIKWDELINFPISVSLLPLEAMLSLSLYG 770

  Fly  1532 ---QYQKDSYDKDYMKKRNLILELLAVEL-----------EFLITWYNPNSLPDLIVPGEEQITE 1582
               |...:|.|.:..:|...:|..:::.|           :.|..|.:|.:|.    ||  ...:
Zfish   771 VLSQNANNSPDSNKQRKGPELLGKVSMPLFDFRRVLSRGSKLLSLWTSPQALQ----PG--AAGK 829

  Fly  1583 WRNRPYKSTVWRDYARLAWCYNPALAVFL--PQR--IKNAEIID-------EEVSRLVC-SDPIA 1635
            .||...|..:..|:.      :||:.|..  ||.  ..|.:.:|       .|:.:|.. :....
Zfish   830 GRNPTEKIILQVDFP------SPAVDVLYVGPQENGCPNPQSLDPLDQDDRSEIEKLCARASTFG 888

  Fly  1636 VCHIPEAL----KYLC-----TTKNLLQESPDL-------VYIL--SWSPVTPIQALAYFSRQYP 1682
            :......|    :|.|     :...:|..:|..       ::.|  .|..::|:.||.....::.
Zfish   889 LSRADRQLLWDQRYYCREYEYSLPKILASAPSWDWGSMGEIHALLHHWPALSPVSALELLESKFA 953

  Fly  1683 SHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHD--TMGYVVEFIKNISRRSQIVAHQLIWNMQ 1745
            ...: .:.||..:.|...:.:..|:||||||::.:  ....:|:|:.:.:..:..:||.|.|.::
Zfish   954 DTEV-RKVAVSWIQSSSDDELADYLPQLVQAVKFECHLKNALVKFLLSRALGNVNIAHYLYWLLR 1017

  Fly  1746 TNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIER 1810
            ..:        :||...:..:::...::.......:...|::......:.|::.::|. |....|
Zfish  1018 DAV--------QDPAFGQRYERILCVLLCLCGTGLRAELEKQTRLVQLLGALAEKVRQ-ASSSTR 1073

  Fly  1811 KNACLAALSRIK---VQGGCYLPSNPEAMVLDIDY-------SSGTPMQSAAKAPYLARFRVYRC 1865
            :...|..|.|::   .:..|.||.:|..:..:::.       |:..|::.|.             
Zfish  1074 QVVLLEGLERVQSFFQKNSCRLPISPSLVAKELNIKVCSFFNSNAVPLKIAL------------- 1125

  Fly  1866 GITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLD 1930
                       |:.:|...|...|           ||||:|:||||||||:|.|...|:.|.|||
Zfish  1126 -----------VNADPLGDEINVM-----------FKVGEDLRQDMLALQMIRIMDRIWLQEGLD 1168

  Fly  1931 LFLFPYRVVATAPGCGVIECVPNAKSRDQL-------GRQTDSGLSEYFQHQYGDESSKEFQAAR 1988
            |.:..::.::|....|::|.||::::..::       |...|..|:|:.: :| :.:..|::.|.
Zfish  1169 LRIVNFKCISTGKDKGMVELVPSSETLRKIQVEYGVTGSFKDKPLAEWLR-KY-NPAEDEYEKAS 1231

  Fly  1989 ANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFG-FMFESSPGGNIGFEPD---MKLT 2049
            .||:.:.|...:..|:|.|.||||.|||:...||:.||||| |:..:...|:  |:.|   ..||
Zfish  1232 ENFIYTCAGCCVATYILGICDRHNDNIMLRSTGHMFHIDFGKFLGHAQMIGS--FKRDRAPFVLT 1294

  Fly  2050 DEMV-MIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRG---------- 2103
            .:|. :|.||:..:..|:.|.:||.||:..:|.:.:..::|:|||..:|||...|          
Zfish  1295 SDMAYVINGGERPTSRFQLFVDLCSQAYNLIRKHSNLFLNLLSLMTQSGLPELTGVQDLKYVYDA 1359

  Fly  2104 ---QTINLLKQRF-----------VATKNNKEAAAHMLAVIRNS--------YQNFRTRTYDMIQ 2146
               ||.:.....|           ||||.|  ...|.||.:|.|        ..:|..|||.|.|
Zfish  1360 LQPQTTDAEATIFFTRLIESSLGSVATKFN--FFIHNLAQLRFSGLPSNDEPILSFAPRTYTMKQ 1422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 37/206 (18%)
PI4Kc_III_alpha 1836..2153 CDD:270711 103/361 (29%)
pik3c2aXP_005159362.2 Amelogenin <137..207 CDD:330537
PI3K_rbd 420..507 CDD:307097 16/110 (15%)
C2A_PI3K_class_II 681..852 CDD:175979 40/197 (20%)
PI3Ka 872..1038 CDD:320871 30/174 (17%)
PKc_like 1045..1397 CDD:328722 107/393 (27%)
PX_PI3K_C2_alpha 1428..1536 CDD:132822
C2B_PI3K_class_II 1565..1686 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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