DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and smg1

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:XP_009297728.1 Gene:smg1 / 569810 ZFINID:ZDB-GENE-061013-767 Length:3641 Species:Danio rerio


Alignment Length:2541 Identity:469/2541 - (18%)
Similarity:762/2541 - (29%) Gaps:960/2541 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 QIVPYLLRLAKCLPKAV-------------W-IDDARSNKV-ERVR--IPSAEKF--------SF 115
            |.|..:|.:|:|.|...             | ||..:.:.: ::|.  :.|.|:|        :.
Zfish   287 QSVKCILLVARCYPHIFSTNFRDTVDILVGWHIDHTQKHSLTQQVSGWLQSLEQFWVADLAFSTT 351

  Fly   116 CLNTLLSDIAAKCPDSREEIILNQVETLSALANIVKSSRDSSSAPPPIILCKATVPLLFGLAR-- 178
            .|...|.|:.|...|               |:::|.........|||.:    ::|.|..|.|  
Zfish   352 LLGQFLEDMEAYAED---------------LSHVVSGESGDEDIPPPTV----SLPKLAALLRVF 397

  Fly   179 -----SMGRYAS--NDPP-------------LLC-----RIFPPE-------------LLPIQKG 205
                 |:|...:  ..||             |.|     ::|..|             |:.|..|
Zfish   398 STVVHSIGERFNPIRGPPITEAYVTDVLNRVLACVTTAKQVFFSEAVLTAGNECVCVLLVSIDLG 462

  Fly   206 G---------GRDGTGSSSSASGTCGGSFSSS---------------------ERLAAT------ 234
            |         |.|    ..:....||..:|.|                     |:|.|.      
Zfish   463 GQLIDAVISYGLD----QLNCCQNCGPEYSLSVLTLLTLVVDQINTKLPASFVEKLLAPKSHLLE 523

  Fly   235 ---HHFRPII--PRSMSGSLAQAQN-----ASYD--DGRQRCA--------GGKPSKPSL-HSYF 278
               |..|.::  ...:..::...:|     |:|.  .|...||        |...:.|.: |..|
Zfish   524 LRFHREREVMAAAHGVYHAVLSLKNIPILEAAYKLVLGEMGCALNSLLSPLGLPDACPHIQHPAF 588

  Fly   279 S-VPYDP-RTHFFTRYG-SSFNQFPNMRVCESPTKGGPRPLYRVPPFPIQHLQTIFAVSKKLLTK 340
            | :.:.| |..|...:. |:.....|       ||.....::.:.|       |:||:..:.|  
Zfish   589 SQLNFSPERAEFVLIFNLSALTTIGN-------TKNSLIGMWALSP-------TVFALLSQNL-- 637

  Fly   341 DTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVTLLRELLQH------QVDLPTPFTKD--- 396
             .:.|     ||:...|....|.          ||.||.....:|      .:...:|...|   
Zfish   638 -VIVH-----SDLAVHHPAVQYA----------VLYTLYSHCTRHDHFISSSLSSSSPSLFDGAV 686

  Fly   397 ---VQEFVKRLF---LNGQTELQNKQQDQERERREENGIAVVNKYKVNVMANAACVDLLVWAI-- 453
               |....||.|   ||....|.:|.......||.                      ||.|::  
Zfish   687 ISTVTTATKRHFSTLLNLLGMLLSKDHLNPEARRL----------------------LLTWSLEV 729

  Fly   454 -----RDETVDVDYNVPSLQNGLQFLLKKEADKLC-GRLSQKLNLE-------------LSHKIV 499
                 :.||....:::||      ||      |.| |.|:..||.:             ||..:.
Zfish   730 ALMMKKSETYAPLFSLPS------FL------KFCKGLLANSLNEDTTICLQACNSLQVLSSSLT 782

  Fly   500 MDHMPLLMVCL---------------EGLGKL------------AHKFPNIAGTSISYLRDFLVA 537
            |:   ||..|:               :..|||            ||....|...|::..|.....
Zfish   783 ME---LLQRCVDVCRVQLVHSAVRVRQAFGKLLRSVPMHVALSSAHSHSEIKEISLAIRRHMSKV 844

  Fly   538 PS--------------------------PILGKLHDHAMQSLAQQKKEKELTP----------FK 566
            ||                          |.|.:|: |:.|.|  :||:..:.|          ::
Zfish   845 PSNTFHPQDFSDLIGFILYGTVHRGGKEPWLERLY-HSCQRL--EKKDSAMVPRALLKTEAVLWQ 906

  Fly   567 IAVQHSDSRTAVVIYGDNQKPPG-------------------------------SGTGRSGHAA- 599
            .||..:...|   :....:.|.|                               .|....||.. 
Zfish   907 WAVWEAAQFT---VLSKLRTPLGRAQDTFQTIEGMIRSLAAHSLNTEQELSQWSGGESDEGHHTN 968

  Fly   600 -------------FESLRDAAIENLSIALRAA--------HTLDQFC------------------ 625
                         .|.|...|.|..:.||.|.        :|..|.|                  
Zfish   969 QLRLALLLQFLENLEKLMYNAYEGCASALTAPPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLS 1033

  Fly   626 -VPALVANVSNRLFTAEKSGSESQGECHKSNLVSLNIIV-----------MLGHVAVALKDTSKT 678
             .||:.......|.|..|:.|....|..    |.:.::|           :.|..|.:|.:|.|:
Zfish  1034 GQPAVTVRHGFDLLTEIKNSSTQGPEME----VPVTMLVEALCELRCPEAIQGLAAWSLANTGKS 1094

  Fly   679 TQNILQFFIQ---RFCKVPSEQNALIVDQLGCMIISQCETHVFD-EIMKMFSRVTVQSASLAYTS 739
            ...:....:|   :|.|...|..    :||..:....|...||| .::|:   ....::|..:||
Zfish  1095 MGWLSSVALQAEGKFEKAALEYQ----EQLCAVTGMDCSIKVFDRSLLKL---TGTNTSSPKHTS 1152

  Fly   740 DPEHRK----QFHHVSDAVVNALGNIAANIQGDAEMLELLGKLLELFVQIGLDGERSYDNTPGAQ 800
            ..|.||    :....|..|:|.|.|                |..|.:|.:. |.|       ..|
Zfish  1153 SGEGRKTVLLKSSECSPEVLNFLAN----------------KACECYVALS-DWE-------SVQ 1193

  Fly   801 KASSRAGNLGMLIPVIAVLVRRLPPIKNPRQRLHKLFKDFWAYCVVMG------FTNAR----LW 855
            :..:...||.                ||.......|..|| .|...|.      ||..|    |.
Zfish  1194 EWQASMMNLK----------------KNSSSSSVNLKTDF-NYIRAMSRFEEGDFTECRAQLELL 1241

  Fly   856 PADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVNELRSQILVLL-----------E 909
            |.|.|          .||.|.|..|.|::.|  ..|:.|...:||:..|.|.|           .
Zfish  1242 PGDDY----------GLLNSTTKDKIDLKRL--LPAVLSPDPSELQKAIEVQLLRSAVGAISATN 1294

  Fly   910 HSSD-NVATAINKLSFAQCTYLLSVYWLEMLRVENADE-PSLEPIMSYLCDTALQRDKTGIWQCV 972
            |..| .||::...:.:.:.|..:.:..|.:..:..:|. |:|..:..: |..:|:..     .|.
Zfish  1295 HEQDQKVASSDTLVKYLKQTGRICLGPLRLSTLTLSDSLPTLSTLQLH-CANSLENS-----LCN 1353

  Fly   973 KCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQ--MVADQYLSFLVDRFPHLL 1035
            :...|.:...|...|....:                     :.:|  :.|.:|.:|..:.|..|.
Zfish  1354 QHPEDCLIPLFSEALTTCKQ---------------------QDVQPWLHALRYTTFQREFFQKLK 1397

  Fly  1036 WNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPA-------------RELR 1087
            .:...:...|..|.|.|...:..........|::|       :.|.||             |:|.
Zfish  1398 GSSSPVDSHLMELCLTAVKFARKQGNIALATRLLS-------LCSKPAMSDTEGQDLVQSFRQLS 1455

  Fly  1088 LKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSK 1152
            |       :|.|.|  ||.|.                       |.:....|:.::.|....|..
Zfish  1456 L-------EGTVGE--KWGPE-----------------------LEIEKAKVLFAAGQSVSAMEM 1488

  Fly  1153 RPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSD---ARHR 1214
            ..||..|        .|...|.  |::...|||:      |...|::| |:....:..   .::.
Zfish  1489 LSSCALS--------YCHSGKC--ELAACRSVLT------LCKWLLAD-WKDLTPQLKMVVKKNS 1536

  Fly  1215 GALWRATAYLIICSEISRKL-LHAVASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVS 1278
            |    :|:...:...||..| |.........:.||:.:...|....:||.....|......|:..
Zfish  1537 G----STSLSTLSKNISGLLELPLEDQGMPHITTETTVSVGVGEPDFVLGQLYQLSTTQAPEVAK 1597

  Fly  1279 AWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEM 1343
            :|...   ....:.|..:|....:..||.     |:|:.......:||     .|...:.||..:
Zfish  1598 SWAAL---ASWAYRWGRKVVDNASQGEGV-----PLLLGEKKEIEELL-----PAGTSDEDKETI 1649

  Fly  1344 FCLL-LHRCLP--------VLKSSK--QNRQVSTVGCRFKLLQC-GLSLLQGNTIPKSLS---RN 1393
            |.:| ...|.|        .|::.:  ::..|..:| |..|..| .||.:: :|:...|.   |.
Zfish  1650 FGILGQAMCRPAGIQDEDMALQNEEDDEDDMVDVIG-RQLLGACPWLSDVE-DTVTDGLIGVWRR 1712

  Fly  1394 ILRERIYS----NALDYF----CGPPTCP-----------NQSREQLLEDIMILLKFWQTMRSEK 1439
            :: :||:|    :...||    ......|           ||:.:|..:|::::... :.:|...
Zfish  1713 VV-DRIFSLYRVSCRAYFTFLKLNAGQVPIDEDDPKLLLNNQNSKQSSDDVIVMATL-RLLRLLV 1775

  Fly  1440 KHLVTSEVG-DYDLTNASVSS-----TQMLAVRNNPET------ASL------------------ 1474
            ||......| ::.|.:...:.     .|:.:..|:||.      .||                  
Zfish  1776 KHAGELREGLEHGLASTPTAPWRGIIPQLFSRLNHPEAYIRQSICSLLCRVAQDSPHLILYPAIV 1840

  Fly  1475 --ISGGGLVNDYTRSMSAS-----GNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRL- 1531
              ||.||........:.:|     ||.  .|.|:.||.|.:|        :...|:.|:|.:.: 
Zfish  1841 GSISLGGEAQTAGNKLPSSLPTLLGNM--QGEGLCGGESETG--------SGPTSQESSRGEEMV 1895

  Fly  1532 -------QYQKDSYDK--DYMKKRN---------LILELLAVELEFLITW--------------- 1563
                   ...:|.|.|  |.:...|         |:.||..|.|.:...|               
Zfish  1896 MYSSEDQAMMQDCYSKIVDKLSSANPTMVLQVQMLVGELRRVTLLWDELWLGVLQQQHMHVLRRI 1960

  Fly  1564 ----------YNPNSL------------------PDLI----------VPGEEQITEWRNRPYKS 1590
                      .|.|:|                  |.:.          .|.|....||....|..
Zfish  1961 QQLEDEVKRVQNNNTLRKDEKVAIMREKHSALMKPVVFALDHVRSITAAPAETPHEEWFQETYGD 2025

  Fly  1591 TVWRDYARLAWCYNPA-----------LAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALK 1644
            .:.....||....|||           :.:.|.||.:      :..|.|:..|.|          
Zfish  2026 AIHNALERLRSPLNPANPASSWVPFKQIMLSLQQRAQ------KRASYLLRLDEI---------- 2074

  Fly  1645 YLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQ 1709
                       ||.|..:.:.....|.:..|       :..:|.|....|::..|.::.    |:
Zfish  2075 -----------SPRLTAMANTEMALPGEVSA-------TDAVTIQSVGNTITILPTKTK----PK 2117

  Fly  1710 LVQALRHDTMGYVVEF--IKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSI 1772
            .:..|..|...|...|  ::::....:|:....|.|   .|:...:||.                
Zfish  2118 KLYFLGSDGRNYPYLFKGLEDLHLDERIMQFLSIVN---TMFTKVNQQE---------------- 2163

  Fly  1773 IASFSGAAKRFYEREFDF------FGKITAVSGEIRSFA--KGIERKNACLAALSRIKVQGGCYL 1829
                   :.||..|.:..      .|.|..|.|....|.  |..:::.|.:.|.   |.|.....
Zfish  2164 -------SPRFQARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQREAVVQAQ---KAQDSFQQ 2218

  Fly  1830 PSN----PEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMT 1890
            |.|    |...  ::.||..:|   |.||..|                :::||.           
Zfish  2219 PQNLPMVPRPS--ELYYSKISP---ALKAVGL----------------SLDVSR----------- 2251

  Fly  1891 LGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAK 1955
               ..|..::.:   ||.::::...                   |..::|....|   .|.    
Zfish  2252 ---RDWPLSVMR---DVLRELMEAT-------------------PPNLLAKELWC---SCT---- 2284

  Fly  1956 SRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMID-K 2019
                                    :..|:.:....:.:|.|..|::||::.:.|||..|::|| .
Zfish  2285 ------------------------TPSEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDMT 2325

  Fly  2020 DGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQD 2084
            .|.::|||:...||......:..:...::|..:...:|.......|:..||..||   .:|..::
Zfish  2326 TGEVVHIDYNVCFEKGKSLRVPEKVPFRMTHNIETALGVTGVEGIFRLSCEQVVQ---IMRRGRE 2387

  Fly  2085 AIVSLV 2090
            .:::|:
Zfish  2388 TLLTLL 2393

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 30/187 (16%)
PI4Kc_III_alpha 1836..2153 CDD:270711 43/256 (17%)
smg1XP_009297728.1 HEAT repeat 143..173 CDD:293787
HEAT repeat 183..216 CDD:293787
HEAT repeat 223..254 CDD:293787
SMG1 622..1231 CDD:292413 136/728 (19%)
PIKKc_SMG1 2100..2406 CDD:270714 73/418 (17%)
FATC 3611..3640 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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