DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and pik3c2b

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:XP_003199535.1 Gene:pik3c2b / 567938 ZFINID:ZDB-GENE-050309-145 Length:1587 Species:Danio rerio


Alignment Length:1284 Identity:263/1284 - (20%)
Similarity:467/1284 - (36%) Gaps:373/1284 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   936 LEMLRVENADEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEK-----FRNVLYAHDEIRE 995
            |::||            .:|.|:. ..::...:|.  .|||....::     .:..:|: |..||
Zfish   288 LDLLR------------SAYPCND-YSKNSGFVWS--PCVAQDELQQGLGVSIKVTVYS-DHFRE 336

  Fly   996 KV---LESQATL-LLVY--FNHIHKPIQMV-ADQYLSFLVDRFPHLLWNRRVL------------ 1041
            .:   .:..:|: ||:|  ..:.|..:.|: .|.||..:..: ...|.|.:.|            
Zfish   337 PLTFSCDGSSTIDLLIYQTLCYAHDDLDMIDVDDYLLKICSQ-AEFLKNTQTLASFEYIQQCLKF 400

  Fly  1042 -WCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKW 1105
             |   ||..:|....|:: .|...|.....||.|:.....|..|.::        |.:..||:..
Zfish   401 DW---DIRLILTKRSSVN-MELARTTEDDDTPSTMNHSILLQERPIK--------QTVTKEALTL 453

  Fly  1106 APRSTRSHLQEY-PNQIPTPVLAHHSGLALAFDSVVSSSA-----QHTGTMSKRPSCVNSDTPRF 1164
            ...:..:..:.: .:::..|:  |...|..:..::.:|.|     ..|..:::.|:|.       
Zfish   454 LLDTFHNEAESFLLSEVELPL--HVERLVQSVKALCTSLAAVETPDITAALNQLPACP------- 509

  Fly  1165 VSVLC-LRSKYAGEISGLLSVLSEKD-KAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIIC 1227
                | |:.|...::    |||::|: :..:.::|.:.:.:...                  :.|
Zfish   510 ----CRLQPKVQKDV----SVLAKKENRVAIVEKLTAAILDLVE------------------LYC 548

  Fly  1228 SEISRKLLHAV--ASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGL 1290
            |..:.. .|.:  :|.......|:.|.|.|..:......|..:          .|..::|.    
Zfish   549 STFNAN-FHTMPHSSRSTAPIQEAGMVTNVLSFSVYAAHRVPI----------TWAASYEN---- 598

  Fly  1291 FAWETEVTHPLAAYEGC-------KLVSKPILIAPHL-IWLQLLSEMVDTAKYCNRDKVEMFCLL 1347
            |.....:||  ...|.|       :.|||.:.   || :|.|.:                     
Zfish   599 FFLSCSLTH--GGVELCAPQHTSKQSVSKYLF---HLVVWDQRV--------------------- 637

  Fly  1348 LHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPT 1412
               |.||                           |.|.:|:   .:.|...:|:..|     || 
Zfish   638 ---CFPV---------------------------QINQLPR---ESQLTVTLYATPL-----PP- 663

  Fly  1413 CPNQSREQLLEDIMILLKFWQTM-RSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLIS 1476
             |..:.|:..:...|....|.|| ....:|::|             ...::|.:.  |.|    .
Zfish   664 -PGGAEEKSKQKRSIESLGWVTMPLFNFRHVLT-------------CGRKLLGLW--PST----P 708

  Fly  1477 GGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRL----QYQKDS 1537
            |.|.....|.:.|...:.:                ..:...||:...|.:.....    ||:...
Zfish   709 GSGNARSSTPNFSQPDSVI----------------LQVDFPTSSFEVRFSTPAPAEFSPQYEFSH 757

  Fly  1538 YDK-------DYMKKRNLILELLAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRD 1595
            .|:       |.:.|::|.             |.:|          |::...|..|.:       
Zfish   758 LDQVSQRQLHDVLHKKSLF-------------WLSP----------EDRRLLWEKRYF------- 792

  Fly  1596 YARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLV 1660
                  |:                   .|.|||    |:.:...| :.::.|.        ||:.
Zfish   793 ------CH-------------------VEASRL----PLVLASAP-SWEWACL--------PDIY 819

  Fly  1661 YIL-SWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTM--GYV 1722
            .:| .|..:..:.||...:..:|... ..:.||:.:.|.....:|.::|||||||:::..  .::
Zfish   820 ALLRQWGCMNHLDALGLLNATFPDQE-CRRTAVQWMDSISDPELLDFLPQLVQALKYECYLDSHL 883

  Fly  1723 VEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYERE 1787
            |.|:...:.....:||.|.|.::..:   :|.|         .....|.::|:....:.|....|
Zfish   884 VRFLLRRAIGDVRIAHYLFWLLKDTL---QDSQ---------FSVRYQYLLAALLCCSGRGLREE 936

  Fly  1788 FD----FFGKITAVSGEIRSFAKGIERKNACLAALSRIK----VQGGCYLPSNPEAMVLDIDYSS 1844
            ||    ....:..|:..:|. |....|:......|..:|    :...|.||.||..:|..|:..|
Zfish   937 FDRQCWLVNVLAKVAQRVRE-ASPSSRQAILREGLDDVKQFFSINSSCRLPLNPGLLVKGINIQS 1000

  Fly  1845 GTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQ 1909
            .:...|.| .|....|:           ....:.:|.|                .|||.|||:||
Zfish  1001 CSYFNSNA-VPLKLSFQ-----------NQDHLGDNIN----------------VIFKAGDDLRQ 1037

  Fly  1910 DMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQH 1974
            |||.||:|.|...|:.|.|||:.:..:|..:|..|.|::|.:|:|::..::  |.:.|::..|:.
Zfish  1038 DMLTLQIIRIMNKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPSAETLRKI--QVEHGVTGSFKD 1100

  Fly  1975 -------QYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFG-FM 2031
                   |..:.:.:|::.|..||:.|.|...:..|:|.|.||||.|||:...||:.||||| |:
Zfish  1101 RPLADWLQKHNPTEEEYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTSGHMFHIDFGKFL 1165

  Fly  2032 FESSPGGNIGFE--PDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLML 2094
            ..:...|||..:  |.:..:|...:|.||...|..|..|.:||.:|:..:|.:....::|:.|||
Zfish  1166 GHAQMFGNIKRDRAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCEAYNRIRKHAHLFLNLLGLML 1230

  Fly  2095 DTGLPCFRGQTINLLKQRFVATK---NNKEAAAHMLAVIRNSYQNFRTR 2140
            .:|:|  ....::.||..:.|.:   :..:|..|...:|.:|..:..|:
Zfish  1231 SSGIP--ELSDVDDLKYVYDALRPHESEADATMHFTRLIESSLGSVATK 1277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 35/177 (20%)
PI4Kc_III_alpha 1836..2153 CDD:270711 93/318 (29%)
pik3c2bXP_003199535.1 PI3K_rbd 322..413 CDD:295323 20/95 (21%)
C2A_PI3K_class_II 569..741 CDD:175979 47/286 (16%)
PI3Ka 763..928 CDD:294194 44/245 (18%)
PI3Kc_C2_beta 934..1287 CDD:119421 107/377 (28%)
PX_domain 1317..1425 CDD:295365
C2B_PI3K_class_II 1458..1579 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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