DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and Mtor

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_063971.1 Gene:Mtor / 56718 RGDID:68371 Length:2549 Species:Rattus norvegicus


Alignment Length:2607 Identity:507/2607 - (19%)
Similarity:841/2607 - (32%) Gaps:929/2607 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 DKYTYQRTVLCLARVLAGIQP---TPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGI---- 64
            |||       |...:..|.:|   ||:...|.:   .||::.|.|..|...:...::..|.    
  Rat   297 DKY-------CKDLMGFGTKPRHITPFTSFQAV---QPQQSNALVGLLGYSSHQGLMGFGASPSP 351

  Fly    65 ---YFLEGGCQHEGQIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAA 126
               ..:|..|..:       |...|......|:...||:|...:::.       .|| ||..:||
  Rat   352 TKSTLVESRCCRD-------LMEEKFDQVCQWVLKCRSSKNSLIQMT-------ILN-LLPRLAA 401

  Fly   127 KCPDSREEIILNQVETLSALANIVKSSRDSSSA-------------------PPPIILCKATVP- 171
            ..|.:..:....| :|::.:.:.||..::.::|                   |..:.:.:|.:| 
  Rat   402 FRPSAFTDTQYLQ-DTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPP 465

  Fly   172 -------------------LLFGLARSMGRYASND-----PPLLCRIFPPEL----------LPI 202
                               .:..|||:||.....|     .|:|.....|.|          :|.
  Rat   466 KDFAHKRQKTVQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQ 530

  Fly   203 QKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGRQRCAGG 267
            .|...:||.....|              |...|  :|:....|...||          .|..:.|
  Rat   531 LKKDIQDGLLKMLS--------------LVLMH--KPLRHPGMPKGLA----------HQLASPG 569

  Fly   268 KPSKPSLHSYFSVPYDPRT-HFFTRYGSSFNQFPNMRVCESPTKGGPRPLYRVPP--------FP 323
            ..:.|......|:....|| ..|...|.|..||  :|.|............|:..        .|
  Rat   570 LTTLPEASDVASITLALRTLGSFEFEGHSLTQF--VRHCADHFLNSEHKEIRMEAARTCSRLLTP 632

  Fly   324 IQHL-------------QTIFAVSKKLLTKD-----------TLEHLDEQASDIFSLHQIKGYCY 364
            ..||             |.:..|..|||...           .|..|||:    |..|..:    
  Rat   633 SIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDER----FDAHLAQ---- 689

  Fly   365 KSFSETLNLVLVTL------LRELLQHQVD-LPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERE 422
               :|.|..:.|.|      :|||....|. |.:.....|..|::::.:...|||          
  Rat   690 ---AENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTEL---------- 741

  Fly   423 RREENGIAVVNKYKV----NVMANA---------ACVDLLVWAIRDETVDVDYNVPSLQNGLQFL 474
              |.:||..:.:...    ::::||         ..:..|:..::|.  |.|.|...:.|.|..:
  Rat   742 --EHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDP--DPDPNPGVINNVLATI 802

  Fly   475 LKKEADKLCGRLSQKLNLELS------HKIVMDHM---PLL---MVCLEGLGKLA---------- 517
                     |.|:|...||:.      ..|:||.:   .||   .|.|..||:|.          
  Rat   803 ---------GELAQVSGLEMRKWVDELFVIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPY 858

  Fly   518 HKFPNIAGTSISYL--------RDFLVAPSPILGKL--HDHAMQ-SLAQQKKEKELTPFKIAVQH 571
            .|:|.:....:::|        |...:....:||.|  :.|.:. .:..|.::..      ||..
  Rat   859 RKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDAS------AVSL 917

  Fly   572 SDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNR 636
            |:|:              |....|.::..|.|  ..:.||        .||:| .||:......|
  Rat   918 SESK--------------SSQDSSDYSTSEML--VNMGNL--------PLDEF-YPAVSMVALMR 957

  Fly   637 LFTAEKSGSESQGECHKSNLVSLNIIVM---LGHVAVA-LKDTSKTTQNILQFFIQRFCKVPSEQ 697
            :|       ..|...|...:|...|..:   ||...|. |.....|..|::     |.|.....:
  Rat   958 IF-------RDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVI-----RVCDGAIRE 1010

  Fly   698 NALIVDQLGCMIISQCETHV---FDEIMKMFSRVTVQSASLAYT--------------------- 738
              .:..||| |::|..::|:   .|||:.:.....|.:.|:..|                     
  Rat  1011 --FLFQQLG-MLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLP 1072

  Fly   739 -SDPEHRKQFHH-------VSDAVVNALGNIAANIQGDAEMLELLGKLLELF--VQIGLDGE--- 790
             ..|...:.|.|       ||..::.|:....||:  |..:..||..:::||  .::.|...   
  Rat  1073 QLIPHMLRVFMHDNSQGRIVSIKLLAAIQLFGANL--DDYLHLLLPPIVKLFDAPEVPLPSRKAA 1135

  Fly   791 -------------------------RSYDNTPGAQKA-----SSRAGNLG----MLIPVI-AVLV 820
                                     |:.|.:|..:..     ||....||    :.||:: .|||
  Rat  1136 LETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV 1200

  Fly   821 RRLPPIKNPRQRLHKLFKDFWAYCVVMGFTNA--------------------------------- 852
                     |.|::....|.....:|.|:|.|                                 
  Rat  1201 ---------RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSSQGDALASGPVETGPMK 1256

  Fly   853 ----------RLWPA-------DWYQGVQQIA------AKSPLLIS----------------QTA 878
                      :.|.|       ||.:.:::::      :.||.|.|                ..|
  Rat  1257 KLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAA 1321

  Fly   879 HKSDMRELN----------YTLAIKSDSVNELRSQILVL---LEHS--------SDNVATAINKL 922
            ..|...|||          ..||:.|..:.|:...:|.|   :|||        .||....:.:.
  Rat  1322 FVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGER 1386

  Fly   923 SFAQC-TYLLSVYWLEMLRVENADEPS-LEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRN 985
            : |:| .|..::::.| |..:....|: ||.::|  .:..||:.:         .|..|.|    
  Rat  1387 A-AKCRAYAKALHYKE-LEFQKGPTPAILESLIS--INNKLQQPE---------AASGVLE---- 1434

  Fly   986 VLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQL 1050
              ||.....|  ||.|||    ::..:|:                     |..          .|
  Rat  1435 --YAMKHFGE--LEIQAT----WYEKLHE---------------------WED----------AL 1460

  Fly  1051 LAYSLSLDPNEETPTLRV------------------VSTPYTLQLMDSLPARELRLKDFADRCQG 1097
            :||...:|.|::.|.|.:                  ....:|| :.|...|:..|:...|....|
  Rat  1461 VAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEKWTL-VNDETQAKMARMAAAAAWGLG 1524

  Fly  1098 IVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTP 1162
                  :|      ..::||...||...   |.|   ||...|  .|.|....|....|:     
  Rat  1525 ------QW------DSMEEYTCMIPRDT---HDG---AFYRAV--LALHQDLFSLAQQCI----- 1564

  Fly  1163 RFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIIC 1227
                                      |||  .|.|.::: .|.|.:|.:|..||:  .:.:::  
  Rat  1565 --------------------------DKA--RDLLDAEL-TAMAGESYSRAYGAM--VSCHML-- 1596

  Fly  1228 SEISRKLLHAVASSQLELFTE------SAMETAVECWQWVLTAR-------QDL-------ELCF 1272
            ||:...:.:.:...:.|:..:      ...:..||.||.:|..|       :|:       .||.
  Rat  1597 SELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCG 1661

  Fly  1273 IQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCN 1337
            ....::....|....:|:.. ..::.|||..            :.|.:.: ..:..|..:|:   
  Rat  1662 KSGRLALAHKTLVLLLGVDP-SRQLDHPLPT------------VHPQVTY-AYMKNMWKSAR--- 1709

  Fly  1338 RDKVEMFCLLLHRCLPVLKSSKQNRQ--VSTVGCRFK------LLQCGLSL------LQG---NT 1385
              |::.|..:.|    .:::.:|..|  ::|...:.|      :.:|.|.|      |||   :|
  Rat  1710 --KIDAFQHMQH----FVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINEST 1768

  Fly  1386 IPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLE-------DIMILLKFWQTMRSEKKHLV 1443
            |||.|       :.||.|.::        ::|..:...       :.::..|.....|.|||.| 
  Rat  1769 IPKVL-------QYYSAATEH--------DRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKL- 1817

  Fly  1444 TSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSS 1508
             ......::|||:.::|          ||:                          ..|...|:.
  Rat  1818 -RHASGANITNATTTAT----------TAA--------------------------SAAAATSTE 1845

  Fly  1509 GWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEF-LITWYNPNSLPDL 1572
            |       |.|.....||.|............:.:.|..|:..:.||:..| .|:....|:|.|.
  Rat  1846 G-------SNSESEAESNESSPTPSPLQKKVTEDLSKTLLLYTVPAVQGFFRSISLSRGNNLQDT 1903

  Fly  1573 IVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVC 1637
            :              ...|:|.||..  |   |.:...|.:.:|..: ||..:.           
  Rat  1904 L--------------RVLTLWFDYGH--W---PDVNEALVEGVKAIQ-IDTWLQ----------- 1937

  Fly  1638 HIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPS---HPLT-AQYAVKTLSSY 1698
            .||:.:..:.|.:.|:..   |::          |.|....|.:|.   :||| |..:..|....
  Rat  1938 VIPQLIARIDTPRPLVGR---LIH----------QLLTDIGRYHPQALIYPLTVASKSTTTARHN 1989

  Fly  1699 PAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWN----MQTNMYMDEDQQHKDP 1759
            .|..:|..:.:....|....|....|.|     |..|:.|:: |:    ..:.:|..|   ....
  Rat  1990 AANKILKNMCEHSNTLVQQAMMVSEELI-----RVAILWHEM-WHEGLEEASRLYFGE---RNVK 2045

  Fly  1760 NLYEALDQLSQSIIASFSGAAKRFYEREFD-FFGKITAVSGE-IRSFAKGIERKNACLA------ 1816
            .::|.|:.|.    |......:...|..|: .:|:....:.| .|.:.|....|:...|      
  Rat  2046 GMFEVLEPLH----AMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYH 2106

  Fly  1817 ALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNP 1881
            ...||..|       .|:...|::.|.|.               ::..|...||........|.|
  Rat  2107 VFRRISKQ-------LPQLTSLELQYVSP---------------KLLMCRDLELAVPGTYDPNQP 2149

  Fly  1882 ---------------NSQEDAKMTLGVESWQAAIF--KVGDDVRQDMLALQ----VITIFKNIFQ 1925
                           :.|...|:||...:....:|  |..:|:|||...:|    |.|:..|...
  Rat  2150 IIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPT 2214

  Fly  1926 QVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQ--------------------------T 1964
            .:..:|.:..|.|:..:...|:|..||:..:...|.|.                          |
  Rat  2215 SLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLT 2279

  Fly  1965 DSGLSEYFQHQY----GDE----------SSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNI 2015
            .....|.|:|..    ||:          ||:.:...|.|:.:|:|..|::||:|.:.|||..|:
  Rat  2280 LMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNL 2344

  Fly  2016 MIDK-DGHIIHIDFGFMFESS------PGGNIGFEPDMKLTDEM-VMIMGGKMDSPAFKWFCELC 2072
            |:|: .|.|:|||||..||.:      | ..|.|.....||:.| |..:.|.     ::..|...
  Rat  2345 MLDRLSGKILHIDFGDCFEVAMTREKFP-EKIPFRLTRMLTNAMEVTGLDGN-----YRTTCHTV 2403

  Fly  2073 VQAFLAVRPYQDAIVS-LVSLMLDTGLPCFRGQTINLLKQRFVAT--KNNKEAAAHMLAVIRNSY 2134
            ::   .:|.::|:::: |.:.:.|.           ||..|.:.|  |.||.:            
  Rat  2404 ME---VLREHKDSVMAVLEAFVYDP-----------LLNWRLMDTNAKGNKRS------------ 2442

  Fly  2135 QNFRTRT 2141
               ||||
  Rat  2443 ---RTRT 2446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 35/182 (19%)
PI4Kc_III_alpha 1836..2153 CDD:270711 86/378 (23%)
MtorNP_063971.1 HEAT repeat 993..1021 CDD:293787 8/35 (23%)
HEAT 25 1029..1068 6/38 (16%)
HEAT repeat 1033..1062 CDD:293787 5/28 (18%)
HEAT 26 1069..1105 6/35 (17%)
HEAT repeat 1073..1099 CDD:293787 5/25 (20%)
HEAT 27 1106..1144 7/39 (18%)
HEAT repeat 1111..1142 CDD:293787 5/30 (17%)
HEAT 28 1145..1188 7/42 (17%)
HEAT repeat 1154..1180 CDD:293787 4/25 (16%)
HEAT 29 1189..1225 12/44 (27%)
HEAT 30 1226..1273 2/46 (4%)
HEAT 31 1274..1311 6/36 (17%)
HEAT 32 1312..1345 6/32 (19%)
TPR 1 1346..1382 9/35 (26%)
TPR 2 1383..1408 5/26 (19%)
TPR 3 1409..1442 11/49 (22%)
TPR 4 1443..1473 12/64 (19%)
TPR 5 1474..1507 4/33 (12%)
TPR 6 1508..1541 9/47 (19%)
TPR 7 1542..1574 13/69 (19%)
TPR 8 1575..1614 8/43 (19%)
TPR 9 1615..1649 6/33 (18%)
TPR 10 1650..1693 7/55 (13%)
TPR 11 1694..1731 8/46 (17%)
TPR 12 1732..1786 16/68 (24%)
TPR 13 1787..1846 14/96 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1812..1867 18/99 (18%)
TPR 14 1898..1930 11/50 (22%)
TPR 15 1931..1970 10/63 (16%)
TPR 16 1971..2005 7/33 (21%)
Sufficient for interaction with the FKBP1A/rapamycin complex. /evidence=ECO:0000250 2012..2144 30/166 (18%)
Rapamycin_bind 2015..2112 CDD:285924 21/109 (19%)
PIKKc_TOR 2153..2431 CDD:270713 69/297 (23%)
Interaction with MLST8. /evidence=ECO:0000250 2258..2296 4/37 (11%)
FATC 2518..2549 CDD:280430
Interaction with NBN. /evidence=ECO:0000250 1..651 76/407 (19%)
TEL1 363..2549 CDD:227365 490/2531 (19%)
HEAT 16 637..683 9/49 (18%)
HEAT repeat 655..681 CDD:293787 6/25 (24%)
HEAT 17 686..724 10/44 (23%)
HEAT repeat 691..721 CDD:293787 9/29 (31%)
HEAT 18 727..766 9/50 (18%)
HEAT repeat 729..759 CDD:293787 7/41 (17%)
HEAT 19 769..811 10/52 (19%)
HEAT repeat 772..805 CDD:293787 8/43 (19%)
HEAT 20 814..853 10/38 (26%)
HEAT repeat 817..847 CDD:293787 9/29 (31%)
DUF3385 854..1024 CDD:288698 43/215 (20%)
HEAT 21 857..893 5/35 (14%)
HEAT 22 894..942 13/77 (17%)
HEAT 23 943..988 13/52 (25%)
HEAT repeat 955..981 CDD:293787 6/32 (19%)
HEAT 24 989..1027 10/45 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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