DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and Mtor

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_064393.2 Gene:Mtor / 56717 MGIID:1928394 Length:2549 Species:Mus musculus


Alignment Length:2607 Identity:507/2607 - (19%)
Similarity:842/2607 - (32%) Gaps:929/2607 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 DKYTYQRTVLCLARVLAGIQP---TPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGI---- 64
            |||       |...:..|.:|   ||:...|.:   .||:..|.|..|...:...::..|.    
Mouse   297 DKY-------CKDLMGFGTKPRHITPFTSFQAV---QPQQPNALVGLLGYSSPQGLMGFGTSPSP 351

  Fly    65 ---YFLEGGCQHEGQIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAA 126
               ..:|..|..:       |...|......|:...||:|...:::.       .|| ||..:||
Mouse   352 AKSTLVESRCCRD-------LMEEKFDQVCQWVLKCRSSKNSLIQMT-------ILN-LLPRLAA 401

  Fly   127 KCPDSREEIILNQVETLSALANIVKSSRDSSSA-------------------PPPIILCKATVP- 171
            ..|.:..:....| :|::.:.:.||..::.::|                   |..:.:.:|.:| 
Mouse   402 FRPSAFTDTQYLQ-DTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPP 465

  Fly   172 -------------------LLFGLARSMGRYASND-----PPLLCRIFPPEL----------LPI 202
                               .:..|||:||.....|     .|:|.....|.|          :|.
Mouse   466 KDFAHKRQKTVQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQ 530

  Fly   203 QKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGRQRCAGG 267
            .|...:||.....|              |...|  :|:....|...||          .|..:.|
Mouse   531 LKKDIQDGLLKMLS--------------LVLMH--KPLRHPGMPKGLA----------HQLASPG 569

  Fly   268 KPSKPSLHSYFSVPYDPRT-HFFTRYGSSFNQFPNMRVCESPTKGGPRPLYRVPP--------FP 323
            ..:.|......|:....|| ..|...|.|..||  :|.|............|:..        .|
Mouse   570 LTTLPEASDVASITLALRTLGSFEFEGHSLTQF--VRHCADHFLNSEHKEIRMEAARTCSRLLTP 632

  Fly   324 IQHL-------------QTIFAVSKKLLTKD-----------TLEHLDEQASDIFSLHQIKGYCY 364
            ..||             |.:..|..|||...           .|..|||:    |..|..:    
Mouse   633 SIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDER----FDAHLAQ---- 689

  Fly   365 KSFSETLNLVLVTL------LRELLQHQVD-LPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERE 422
               :|.|..:.|.|      :|||....|. |.:.....|..|::::.:...|||          
Mouse   690 ---AENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTEL---------- 741

  Fly   423 RREENGIAVVNKYKV----NVMANA---------ACVDLLVWAIRDETVDVDYNVPSLQNGLQFL 474
              |.:||..:.:...    ::::||         ..:..|:..::|.  |.|.|...:.|.|..:
Mouse   742 --EHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDP--DPDPNPGVINNVLATI 802

  Fly   475 LKKEADKLCGRLSQKLNLELS------HKIVMDHM---PLL---MVCLEGLGKLA---------- 517
                     |.|:|...||:.      ..|:||.:   .||   .|.|..||:|.          
Mouse   803 ---------GELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPY 858

  Fly   518 HKFPNIAGTSISYL--------RDFLVAPSPILGKL--HDHAMQ-SLAQQKKEKELTPFKIAVQH 571
            .|:|.:....:::|        |...:....:||.|  :.|.:. .:..|.::..      ||..
Mouse   859 RKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDAS------AVSL 917

  Fly   572 SDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNR 636
            |:|:              |....|.::..|.|  ..:.||        .||:| .||:......|
Mouse   918 SESK--------------SSQDSSDYSTSEML--VNMGNL--------PLDEF-YPAVSMVALMR 957

  Fly   637 LFTAEKSGSESQGECHKSNLVSLNIIVM---LGHVAVA-LKDTSKTTQNILQFFIQRFCKVPSEQ 697
            :|       ..|...|...:|...|..:   ||...|. |.....|..|::     |.|.....:
Mouse   958 IF-------RDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVI-----RVCDGAIRE 1010

  Fly   698 NALIVDQLGCMIISQCETHV---FDEIMKMFSRVTVQSASLAYT--------------------- 738
              .:..||| |::|..::|:   .|||:.:.....|.:.|:..|                     
Mouse  1011 --FLFQQLG-MLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLP 1072

  Fly   739 -SDPEHRKQFHH-------VSDAVVNALGNIAANIQGDAEMLELLGKLLELF--VQIGLDGE--- 790
             ..|...:.|.|       ||..::.|:....||:  |..:..||..:::||  .::.|...   
Mouse  1073 QLIPHMLRVFMHDNSQGRIVSIKLLAAIQLFGANL--DDYLHLLLPPIVKLFDAPEVPLPSRKAA 1135

  Fly   791 -------------------------RSYDNTPGAQKA-----SSRAGNLG----MLIPVI-AVLV 820
                                     |:.|.:|..:..     ||....||    :.||:: .|||
Mouse  1136 LETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLV 1200

  Fly   821 RRLPPIKNPRQRLHKLFKDFWAYCVVMGFTNA--------------------------------- 852
                     |.|::....|.....:|.|:|.|                                 
Mouse  1201 ---------RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSSQGDALASGPVETGPMK 1256

  Fly   853 ----------RLWPA-------DWYQGVQQIA------AKSPLLIS----------------QTA 878
                      :.|.|       ||.:.:::::      :.||.|.|                ..|
Mouse  1257 KLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAA 1321

  Fly   879 HKSDMRELN----------YTLAIKSDSVNELRSQILVL---LEHS--------SDNVATAINKL 922
            ..|...|||          ..||:.|..:.|:...:|.|   :|||        .||....:.:.
Mouse  1322 FVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGER 1386

  Fly   923 SFAQC-TYLLSVYWLEMLRVENADEPS-LEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRN 985
            : |:| .|..::::.| |..:....|: ||.::|  .:..||:.:         .|..|.|    
Mouse  1387 A-AKCRAYAKALHYKE-LEFQKGPTPAILESLIS--INNKLQQPE---------AASGVLE---- 1434

  Fly   986 VLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQL 1050
              ||.....|  ||.|||    ::..:|:                     |..          .|
Mouse  1435 --YAMKHFGE--LEIQAT----WYEKLHE---------------------WED----------AL 1460

  Fly  1051 LAYSLSLDPNEETPTLRV------------------VSTPYTLQLMDSLPARELRLKDFADRCQG 1097
            :||...:|.|:|.|.|.:                  ....:|| :.|...|:..|:...|....|
Mouse  1461 VAYDKKMDTNKEDPELMLGRMRCLEALGEWGQLHQQCCEKWTL-VNDETQAKMARMAAAAAWGLG 1524

  Fly  1098 IVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTP 1162
                  :|      ..::||...||...   |.|   ||...|  .|.|....|....|:     
Mouse  1525 ------QW------DSMEEYTCMIPRDT---HDG---AFYRAV--LALHQDLFSLAQQCI----- 1564

  Fly  1163 RFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIIC 1227
                                      |||  .|.|.::: .|.|.:|.:|..||       ::.|
Mouse  1565 --------------------------DKA--RDLLDAEL-TAMAGESYSRAYGA-------MVSC 1593

  Fly  1228 ---SEISRKLLHAVASSQLELFTE------SAMETAVECWQWVLTAR-------QDL-------E 1269
               ||:...:.:.:...:.|:..:      ...:..||.||.:|..|       :|:       .
Mouse  1594 HMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYAS 1658

  Fly  1270 LCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAK 1334
            ||              .:.|..|...:....|...:..:.:..|:..|...:....:..|..:|:
Mouse  1659 LC--------------GKSGRLALAHKTLVLLLGVDPSRQLDHPLPTAHPQVTYAYMKNMWKSAR 1709

  Fly  1335 YCNRDKVEMFCLLLHRCLPVLKSSKQNRQ--VSTVGCRFK------LLQCGLSL------LQG-- 1383
                 |::.|..:.|    .:::.:|..|  ::|...:.|      :.:|.|.|      |||  
Mouse  1710 -----KIDAFQHMQH----FVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGIN 1765

  Fly  1384 -NTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLE-------DIMILLKFWQTMRSEKK 1440
             :||||.|       :.||.|.::        ::|..:...       :.::..|.....|.|||
Mouse  1766 ESTIPKVL-------QYYSAATEH--------DRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKK 1815

  Fly  1441 HLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGG 1505
            .|  ......::|||:.::|                        |.:.:|:..:.        .|
Mouse  1816 KL--RHASGANITNATTAAT------------------------TAASAAAATST--------EG 1846

  Fly  1506 SSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEF-LITWYNPNSL 1569
            |:|       .|.:..::.|.....|| :|.:.|   :.|..|:..:.||:..| .|:....|:|
Mouse  1847 SNS-------ESEAESNENSPTPSPLQ-KKVTED---LSKTLLLYTVPAVQGFFRSISLSRGNNL 1900

  Fly  1570 PDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPI 1634
            .|.:              ...|:|.||..  |   |.:...|.:.:|..: ||..:.        
Mouse  1901 QDTL--------------RVLTLWFDYGH--W---PDVNEALVEGVKAIQ-IDTWLQ-------- 1937

  Fly  1635 AVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPS---HPLT-AQYAVKTL 1695
               .||:.:..:.|.:.|:..   |::          |.|....|.:|.   :||| |..:..|.
Mouse  1938 ---VIPQLIARIDTPRPLVGR---LIH----------QLLTDIGRYHPQALIYPLTVASKSTTTA 1986

  Fly  1696 SSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWN----MQTNMYMDEDQQH 1756
            ....|..:|..:.:....|....|....|.|     |..|:.|:: |:    ..:.:|..|   .
Mouse  1987 RHNAANKILKNMCEHSNTLVQQAMMVSEELI-----RVAILWHEM-WHEGLEEASRLYFGE---R 2042

  Fly  1757 KDPNLYEALDQLSQSIIASFSGAAKRFYEREFD-FFGKITAVSGE-IRSFAKGIERKNACLA--- 1816
            ....::|.|:.|.    |......:...|..|: .:|:....:.| .|.:.|....|:...|   
Mouse  2043 NVKGMFEVLEPLH----AMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDL 2103

  Fly  1817 ---ALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVS 1878
               ...||..|       .|:...|::.|.|.               ::..|...||........
Mouse  2104 YYHVFRRISKQ-------LPQLTSLELQYVSP---------------KLLMCRDLELAVPGTYDP 2146

  Fly  1879 NNP---------------NSQEDAKMTLGVESWQAAIF--KVGDDVRQDMLALQ----VITIFKN 1922
            |.|               :.|...|:||...:....:|  |..:|:|||...:|    |.|:..|
Mouse  2147 NQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLAN 2211

  Fly  1923 IFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQ------------------------ 1963
            ....:..:|.:..|.|:..:...|:|..||:..:...|.|.                        
Mouse  2212 DPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYD 2276

  Fly  1964 --TDSGLSEYFQHQY----GDE----------SSKEFQAARANFVKSMAAYSLIGYLLQIKDRHN 2012
              |.....|.|:|..    ||:          ||:.:...|.|:.:|:|..|::||:|.:.|||.
Mouse  2277 HLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHP 2341

  Fly  2013 GNIMIDK-DGHIIHIDFGFMFESS------PGGNIGFEPDMKLTDEM-VMIMGGKMDSPAFKWFC 2069
            .|:|:|: .|.|:|||||..||.:      | ..|.|.....||:.| |..:.|.     ::..|
Mouse  2342 SNLMLDRLSGKILHIDFGDCFEVAMTREKFP-EKIPFRLTRMLTNAMEVTGLDGN-----YRTTC 2400

  Fly  2070 ELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSY 2134
            ...::   .:|.::|::::::...:...|..:|....|        ||.||.:            
Mouse  2401 HTVME---VLREHKDSVMAVLEAFVYDPLLNWRLMDTN--------TKGNKRS------------ 2442

  Fly  2135 QNFRTRT 2141
               ||||
Mouse  2443 ---RTRT 2446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 35/182 (19%)
PI4Kc_III_alpha 1836..2153 CDD:270711 84/375 (22%)
MtorNP_064393.2 Interaction with NBN. /evidence=ECO:0000250 1..651 76/407 (19%)
TEL1 363..2549 CDD:227365 490/2531 (19%)
HEAT 16 637..683 9/49 (18%)
HEAT repeat 655..681 CDD:293787 6/25 (24%)
HEAT 17 686..724 10/44 (23%)
HEAT repeat 691..721 CDD:293787 9/29 (31%)
HEAT 18 727..766 9/50 (18%)
HEAT repeat 729..759 CDD:293787 7/41 (17%)
HEAT 19 769..811 10/52 (19%)
HEAT repeat 772..805 CDD:293787 8/43 (19%)
HEAT 20 814..853 10/38 (26%)
HEAT repeat 817..847 CDD:293787 9/29 (31%)
DUF3385 854..1024 CDD:288698 43/215 (20%)
HEAT 21 857..893 5/35 (14%)
HEAT 22 894..942 13/77 (17%)
HEAT 23 943..988 13/52 (25%)
HEAT repeat 955..981 CDD:293787 6/32 (19%)
HEAT 24 989..1027 10/45 (22%)
HEAT repeat 993..1021 CDD:293787 8/35 (23%)
HEAT 25 1029..1068 6/38 (16%)
HEAT repeat 1033..1062 CDD:293787 5/28 (18%)
HEAT 26 1069..1105 6/35 (17%)
HEAT repeat 1073..1099 CDD:293787 5/25 (20%)
HEAT 27 1106..1144 7/39 (18%)
HEAT repeat 1111..1142 CDD:293787 5/30 (17%)
HEAT 28 1145..1188 7/42 (17%)
HEAT repeat 1154..1180 CDD:293787 4/25 (16%)
HEAT 29 1189..1225 12/44 (27%)
HEAT 30 1226..1273 2/46 (4%)
HEAT 31 1274..1311 6/36 (17%)
HEAT 32 1312..1345 6/32 (19%)
TPR 1 1346..1382 9/35 (26%)
TPR 2 1383..1408 5/26 (19%)
TPR 3 1409..1442 11/49 (22%)
TPR 4 1443..1473 12/64 (19%)
TPR 5 1474..1507 4/33 (12%)
TPR 6 1508..1541 9/47 (19%)
TPR 7 1542..1574 13/69 (19%)
TPR 8 1575..1614 9/46 (20%)
TPR 9 1615..1649 6/33 (18%)
TPR 10 1650..1693 6/56 (11%)
TPR 11 1694..1731 7/45 (16%)
TPR 12 1732..1786 16/68 (24%)
TPR 13 1787..1846 12/92 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1825..1867 13/81 (16%)
TPR 14 1898..1930 11/50 (22%)
TPR 15 1931..1970 10/63 (16%)
TPR 16 1971..2005 7/33 (21%)
Sufficient for interaction with the FKBP1A/rapamycin complex 2012..2144 30/166 (18%)
Rapamycin_bind 2015..2112 CDD:285924 21/109 (19%)
PIKKc_TOR 2153..2431 CDD:270713 66/286 (23%)
Interaction with MLST8. /evidence=ECO:0000250 2258..2296 4/37 (11%)
FATC 2518..2549 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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