Protein Alignment Pi4KIIIalpha and si:rp71-17i16.5

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: XP_021329311.1
• Gene: si:rp71-17i16.5 / 564261
• ZFINID: ZDB-GENE-090312-117
• Length: 1069
• Species: Danio rerio
• Alignment Length: 1078
• Identity: 233/1078 - (21%)
• Similarity: 386/1078 - (35%)
• Gaps: 350/1078 - (32%)

  Fly  1183 SVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAY-----LIICSEISRKLLHAVASSQ 1242
            |::...|:.|...|.:|                    .|.|     |.|.:::::|     .|..
Zfish   189 SIVLPNDQQGYFQRTLS--------------------VTLYYNGSNLSIKADLTQK-----PSDI 228

  Fly  1243 LELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGC 1307
            |::|.||..:.::....|  |:...|::|..:|.:|.     :.::..:.|
Zfish   229 LKIFWESLPKGSLPIESW--TSDHVLKVCGREEFLSG-----DFQLSNYLW-------------- 272

  Fly  1308 KLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFK 1372
                                     .::|.::.:|     ||              :|.|
Zfish   273 -------------------------VRHCLKNSLE-----LH--------------LSVV----- 288

  Fly  1373 LLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQL------LEDIMILLKF 1431
                .:|.|..:|:...          |...:|...|    .:.|.|:|      :||| :|:..
Zfish   289 ----AISSLPDDTVSTE----------YWPLVDSLTG----LSSSHEELCLKKKEVEDI-VLISL 334

  Fly  1432 WQTMRSEKKHLVTSEVGDY-----------------DLTNASVSSTQM---------------LA 1464
            |...|..:..|:..::.|.                 ..|.:|:.||..               :.
Zfish   335 WDCERKFRVKLLGFDIPDLPSKVPSLVYVEATIIYGKKTISSICSTPKEFTDEVLWNTWLEFDIL 399

  Fly  1465 VRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSK 1529
            :|:.|:.|.|    ||                                ||..:.:....:|:.||
Zfish   400 IRDIPQGAKL----GL--------------------------------TINATEAAKETKSSSSK 428

  Fly  1530 RLQYQKDSYDKDYMKKRNLI----------------------LELLAVELEFLITWYNPN----- 1567
            ...:.|......|.....||                      .|.:..|.:.|.|..||:
Zfish   429 VPDHHKGKLQVLYFVNLQLIDHRSLLSQGPHTLNMWPFPEWDEEAVTYEADKLSTATNPDVANSM 493

  Fly  1568 ---------SLPDLIVPGEEQITEWRNRPYKSTVWRDYA---RLAWCYNPALAVFLPQRIKNAEI 1620
                     |.| :::|.....:.....|...:...|.|   ||:..::.|.:.....|::|.:.
Zfish   494 AITFMLDRYSFP-VVLPNGRSSSCSGTSPVSESSSLDLAGESRLSAPFSEASSTATLTRMRNLKK 557

  Fly  1621 IDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLV----YILS-WSP--VTPIQALAYFS 1678
            ..||          :|.::....::|.|...:|   |.:|    ::|| |.|  :....||...|
Zfish   558 FKEE----------SVHYVSNLPQFLRTVNWML---PTVVQEVHWLLSHWGPEDIELFVALELLS 609

  Fly  1679 RQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALR----HDTMGYVVEFIKNISRRSQIVAHQ 1739
            ..:....: .:.||:.|.....:.||.|:.||||.|:    ||:  ::..|:...:.||:.:.|.
Zfish   610 VDFADLKV-RRLAVQRLEILSNDEVLKYLLQLVQTLKVEPYHDS--FLARFLLKRALRSKRIGHF 671

  Fly  1740 LIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSF 1804
            ..|.:::.:                            :|.         .||.:..||..|....
Zfish   672 FFWYLRSEV----------------------------AGC---------PFFRQRMAVILEAYLL 699

  Fly  1805 AKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAA---------KAPYLARF 1860
            ..|    .|.||.. :.:||...||  :..|:.:.:.|...|.:.|.|         |....:.|
Zfish   700 GCG----EAMLAEF-QSQVQVVSYL--HDVALAVKLLYPDRTDLPSTAPQKLQELLEKCDLPSDF 757

  Fly  1861 RV-----YRCG-ITELETRAMEVSNNP--------NSQEDAKMTLGVESWQAAIFKVGDDVRQDM 1911
            :|     .|.| |...:.:.|.....|        .|:......:|:      |||.|||:||||
Zfish   758 QVPFDPRVRAGSIILKDCKIMASKKKPLWLEFSCIQSEAPPSPPVGI------IFKHGDDLRQDM 816

  Fly  1912 LALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNA-----KSRDQ---LGRQTDSGL 1968
            |.:|.:.:..:|:|:.||||.|.||..::|....|:||.|.||     ..|.|   .|...::.|
Zfish   817 LIIQTLVVMDSIWQEKGLDLNLVPYGCISTGFNIGMIEIVRNAITIASVQRSQGGVAGAFKNNAL 881

  Fly  1969 SEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMF- 2032
            .::.|.:...: .|.|||.. .||.|.|.|.:..|:|.|.||||.||||...|::.|||||.:.
Zfish   882 YDWLQTKCPFQ-EKHFQATE-KFVNSCAGYCVATYVLGIGDRHNDNIMITDQGNLFHIDFGHILG 944

  Fly  2033 --ESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPA--FKWFCELCVQAFLAVRPYQDAIVSLVSLM 2093
              :|..|.|....| ..||.:.:.:||.....|:  |:.|.:.|:.|:|::|.....:|:|.|||
Zfish   945 NTKSFWGVNRERVP-FVLTPDFLYVMGRVKGRPSLYFQRFRDTCINAYLSLRAQSRLLVTLFSLM 1008

  Fly  2094 LDTGLP-CFRGQTINLLKQRFVATKNNKEAAAHMLAVI 2130
            |.||:| ....|.:..|:......::.:||..|:|..|
Zfish  1009 LLTGIPELSMSQDMLYLRTALQQDQSEEEARNHLLQQI 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	36/185 (19%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	104/332 (31%)
si:rp71-17i16.5	XP_021329311.1	PI3K_rbd	189..292	CDD:321949	28/201 (14%)
		C2	332..506	CDD:326325	31/210 (15%)
		PI3Ka	557..702	CDD:320871	39/197 (20%)
		PI3Kc_IB_gamma	706..1069	CDD:270627	111/353 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810