DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and pi4kb

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	XP_005158276.1	Gene:	pi4kb / 563201	ZFINID:	ZDB-GENE-061013-96	Length:	850	Species:	Danio rerio

Alignment Length:	874	Identity:	201/874 - (22%)
Similarity:	343/874 - (39%)	Gaps:	230/874 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1448 GDYDLTNASVSSTQMLAVRNNP----------------------------ETASLISGGGLVNDY 1484
            |.:.||::|.|:::.|...:.|                            :....:.|.|.|:
Zfish    37 GPHPLTSSSPSTSEGLPTSSPPLDVISEGLGELSLVIDTEVAKKACQEVLQKVKFLKGDGEVS-- 99

  Fly  1485 TRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLI 1549
                |||...: :..|.|...::.|..   |...|.......:|.|.:.:.:|..:.::.:   :
Zfish   100 ----SASSEPI-LANGTAHPEANDGGQ---PPKISEEEVEPIKSVRRRQKNNSSKQSWLLR---L 153

  Fly  1550 LELLAVELEFLITW-YNPNSLPDLIVPGEE-----QITEWRNRPYKSTVWRDYARLAWCYNPALA 1608
            .|....::...|:: ||...      ||.:     ::..:||...      |:
Zfish   154 FESKLFDISMAISYLYNSKE------PGVQAYIGNRLFSFRNEDV------DF------------ 194

  Fly  1609 VFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILS--WSPVTPI 1671
             :|||.:.....:||:|...:  .|..|....:::.:......||......::|.:  .|..|.:
Zfish   195 -YLPQLLNMYIHMDEDVGDAI--KPYVVYRCRQSINFSLQCAWLLGAYSSDMHISTQRHSRGTKL 256

  Fly  1672 QALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMG---YVVEFIKNISRRS 1733
            :.|.......||    :|...:.:...|.    ||.|.|     |...|   :.:...|...:||
Zfish   257 RKLILSDELKPS----SQRIRREVPQPPP----PYPPPL-----HHGPGMSEHSLSPSKRTHQRS 308

  Fly  1734 Q---IVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKIT 1795
            :   .|:..|..|::......:.:..:|.:|..:.|.|...     :|...|...:. :|...:.
Zfish   309 KSDATVSISLSSNLKRTASNPKVETSQDEDLSSSSDSLELE-----AGTPVRLTPQR-EFIKSLM 367

  Fly  1796 AVSGEIRSFAKGIERKNACLAALSRI--KVQGGCYLPSNP-EAMVLDIDYSSGTPMQSAAKAPYL 1857
            .:...:.:.....::....::.||.:  |:....:||:.. :..|:.:.::....:.|..|||||
Zfish   368 GIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAAFDHHVVRVPHTQAVVLNSKDKAPYL 432

  Fly  1858 ARFRVYR-----------------------------CGIT------------------------- 1868
            ....|..                             ||||
Zfish   433 IYVEVLECENFETSSVPVRIPETQIRSTRSVENLPDCGITPDQRASSFSTVPNYDNDDEAWSVDD 497

  Fly  1869 --ELETRAMEVSNNP------------NSQE----------DAKMTLG----------------- 1892
              ||:....|:..|.            .|||          |.:..|.
Zfish   498 IGELQVELPEIHTNSCDNISQFSVDSITSQESKEPIFIAAGDIRRRLSEQLAHTPTTFRKDPEDP 562

  Fly  1893 -----VESWQ---------------------AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDL 1931
                 .|.||                     :.|.|.|||:||::||.||:...:.|::|..:.|
Zfish   563 SAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAYQVLKQLQIIWEQERVPL 627

  Fly  1932 FLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMA 1996
            ::.||:::..:...|:||.|.||.|..|:.:|:...|.:||:.::|:.:::||..|:.|||:|.|
Zfish   628 WIKPYKILVISSDSGMIEPVVNAVSIHQVKKQSQLLLLDYFRQEHGNFNTEEFLTAQRNFVQSCA 692

  Fly  1997 AYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPD-MKLTDEMVMIMGGKM 2060
            .|.||.||||:||||||||::|.:||||||||||:..||| .|:|||.. .|||.|.|.:||| :
Zfish   693 GYCLICYLLQVKDRHNGNILLDSEGHIIHIDFGFILSSSP-RNLGFETSAFKLTSEFVDVMGG-L 755

  Fly  2061 DSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLD-TGLPCFRG-QTINLLKQRFVATKNNKEAA 2123
            |...|.::..|.:|..:|.|.:.:.::.:|.:|.. :.||||.| .||..||:||......::..
Zfish   756 DGDMFNYYKMLMLQGLIAARKHMEKVIQIVEIMQQGSQLPCFHGSSTIRNLKERFHMNLTEEQLQ 820

  Fly  2124 AHMLAVIRNSYQNFRTRTYDMIQYYQNQI 2152
            ..:..::..|.::..|:.||..||..|.|
Zfish   821 VLVEQMVDGSMRSITTKLYDGFQYLTNGI 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	34/182 (19%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	129/441 (29%)
pi4kb	XP_005158276.1	PI4Kc_III_beta	563..850	CDD:270712	108/289 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820