DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and prkdc

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:XP_009301676.1 Gene:prkdc / 562283 ZFINID:ZDB-GENE-030131-9008 Length:4119 Species:Danio rerio


Alignment Length:2327 Identity:408/2327 - (17%)
Similarity:719/2327 - (30%) Gaps:820/2327 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   335 KKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVTLLRELLQHQV-----------D 388
            |::|::|....|:   .|..:.|:    |..:        :..|||.:.::.:           |
Zfish  2080 KEVLSQDETVELE---MDELNQHE----CMAN--------MTALLRHMQRNNITPKVEEGVRPSD 2129

  Fly   389 LPTPFTK-------------DVQEFVKRLFLNGQTELQNKQQD-----QERERREENGIAVVNKY 435
            || |:.|             :::.|:.:|.:|.:...:...:.     .:......||...::..
Zfish  2130 LP-PWMKFLQGKLDNPSTPLNIRLFIAKLIINTEEIFRPYAKHWLGPLMQLVVSSSNGGEGIHFM 2193

  Fly   436 KVNVMANAACVDLLVWA--------IRDETVDVDYNVPSLQNGLQFLLKKEADKLC---GRLSQK 489
            .|:::     |.:|.||        .|||.:        :...|.||.|.     |   .|...:
Zfish  2194 VVDIV-----VTVLSWASVASPKGNTRDEVL--------VNRLLGFLFKN-----CFHSKRAVFR 2240

  Fly   490 LNLELSHKIVMDHMPLLMVCLEGL-GKLAHKFPNIAGTSIS------YLRDFLVAPSPILGKLHD 547
            .|||:...:|......|.:..:.: .:.|...||....|:.      .:.:.|.......|..||
Zfish  2241 HNLEIIRTVVECWKDCLTIPYDLIYERFAGTDPNSKDNSVGIQLLGIVMANNLPPYDAACGIEHD 2305

  Fly   548 HAMQSLA---------------------------QQKKEKELTPFKIAV--------QHSDSRTA 577
            ...||||                           :::.:.|.|.|.|.|        :..|.:..
Zfish  2306 RYFQSLANNLSFIRYKEVYSAAAEVIGLILNYMTERENQIEGTLFNITVTKLMDLRKKEVDDKFI 2370

  Fly   578 VVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAH-TLDQFCVPALV--ANVSNRLFT 639
            |.:           :..|.|  |..|.|..|..:...|...| .|...|:..::  |:|...:|.
Zfish  2371 VCL-----------SKVSKH--FPPLVDRFINPVFYLLPKLHGMLKTHCLECVLSRADVIPEIFL 2422

  Fly   640 AEKSGSESQGECHKS---NLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQNALI 701
            ..|:...||...||.   ..|.|:||    |..:|                   |..|.|...::
Zfish  2423 HLKTKGLSQIMSHKDEGRQRVCLDII----HKILA-------------------CLKPEELKEIL 2464

  Fly   702 --VDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQFHHVSDAVVNALGNIAAN 764
              |..........|...::|.:|.:....          ||.|.|:                   
Zfish  2465 GAVTAFASHPSPVCRERMYDILMWIQDNY----------SDSESRE------------------- 2500

  Fly   765 IQGDAEMLELLGKLLELFVQIGLDGERSYDNTPGAQKASSRAGNLGMLIPVIAVLVR-------R 822
               |:..:|:|....|..:| ||..|                 |.|     :.:.||       |
Zfish  2501 ---DSTSVEVLSVARETLLQ-GLTDE-----------------NYG-----LQLYVRNFWSHESR 2539

  Fly   823 LPPIKNPRQRLHKLFKDFWAYCVVMGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSD----M 883
            |||  ...:|:..:.|..::..:...|                ::..:.||:..|:|..|    |
Zfish  2540 LPP--ETLERMLVVLKSLYSSRIEEQF----------------LSLATDLLLEMTSHSPDFTRNM 2586

  Fly   884 REL--------NYTLAIKSDSVNELRSQILVLL----------EHSSDNVATAINKLSFAQCTYL 930
            .|.        :||:    ||...:||.:|..:          |.:....||...::...|.:..
Zfish  2587 FEFPLSECKFQDYTI----DSNWRMRSTVLTPMFMETQATQGAEAAGSQAATVRGQIRATQTSLE 2647

  Fly   931 L-----------SVY-WLEMLRVENADEPSL--EPIMSYLC-DTALQRDKTGIWQCV-------- 972
            .           |.| ||....|:...:.||  :.:.|.|. |..........|:.|        
Zfish  2648 FSQTLAPGAGRRSAYNWLTGSSVDTLADYSLSSDSLSSLLVFDKKRSERPQAAWRAVGAGFGSKR 2712

  Fly   973 ----------KCVADQVFEKFRNVL----------------YAHDEIREKVLE------------ 999
                      :..|::  |:..::|                :|..||..:..|            
Zfish  2713 LTATSDDTDSRTAAER--ERRADILRLRRRFLKDKEKESIKFAKKEIHSQRTERERRADLKIRQD 2775

  Fly  1000 SQATL-----------LLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAY 1053
            :|.||           :.:.|:.:..|:|.:|.:..:.....|..|            ...:|..
Zfish  2776 AQVTLYRSYRVGDLPDIQIQFSSLIAPLQALAQRDATLAKQLFSSL------------FAGVLVE 2828

  Fly  1054 SLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYP 1118
            ...|..|:||..:                     ||:........:|::..:.|... |.:|:  
Zfish  2829 MERLKSNKETADI---------------------LKELVQTLNAFLNKSTVYFPPFI-SCIQD-- 2869

  Fly  1119 NQIPTPVLAHHSGLALAFDSVVSS-----------------SAQHTGTMSKRPSCVNS------- 1159
                  :..||..|.....|:||:                 |..|....|:.|....:       
Zfish  2870 ------MSYHHKALLGVEPSLVSATCLASLQQPMGILLLEESLLHGAGASEEPPLKRARGKRELP 2928

  Fly  1160 -DTPRFVSVLCL----------RSKYAGEI---SGLLSVLSEKDKAGLADRL------------- 1197
             ||.|::.:..|          |..::|:|   |...:.|..:.|:..|:.:             
Zfish  2929 PDTERWIHLAKLYRSLGDYDVVRGIFSGKIGTKSITFTALQAEAKSDYAEAVKLYNEALNKEDWD 2993

  Fly  1198 -------VSDVWEACA---------------------EKSDARHRGALWRATAYL-----IICSE 1229
                   ..|.||..|                     :.|.......:|..|.|:     .:...
Zfish  2994 DGEPTITEKDFWEIAALEAYNHLTEWKSLEYCATVNIDDSSPIRLDRMWTETFYVETYLQYMMRS 3058

  Fly  1230 ISRKLLHAVASSQLELFTESAMETAVECWQWVLTAR--QDLELCFI-QEMVSAWQTTFEKRMGLF 1291
            :.::|.....:..|..|.::||:|  |..:.::...  |:|.|.:| ||.....:......|.:|
Zfish  3059 MLKQLQMGETNQDLLSFVDAAMKT--EEHKIIMETHYSQELSLLYILQEDYDRAKYYANNCMQVF 3121

  Fly  1292 AWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRD----------------- 1339
            ........||.......::..          :|.|:|:.|...|...|                 
Zfish  3122 MQNYSSIDPLLNRSRLTVLQS----------VQALTEIQDFLNYITGDVSVNSLKFMIRRWTSHY 3176

  Fly  1340 ---KVEMF----------CLLLHRCLPVLKSSKQNRQ--------------VSTVGCRFKL-LQC 1376
               |::..          |..|.:.|..|||:.:|..              |....|:|.: ||.
Zfish  3177 PDAKLDPMNVWDDIITSRCFFLDKILKRLKSTPENSMEVDGADQGSGEELGVLVKTCKFNMKLQM 3241

  Fly  1377 GLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKH 1441
            ..|..:.|..|  ::..:|:|                  ..|...::|..:|.  |....|...|
Zfish  3242 ADSAWKQNNFP--VASKLLKE------------------LHRHAKIDDARLLR--WVHSFSRFTH 3284

  Fly  1442 LVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGS 1506
            ...:.:|..:..||.:.:..:|   .:.|..|......::.|....:..:.:.      :||...
Zfish  3285 KRIARLGPSEKINALLKTVPLL---KDAERQSEALSARMLRDQRILLGTTYDL------MAGAAD 3340

  Fly  1507 SSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPD 1571
            .|      |.:..||.:...: |.||..:.|.....::.    |::.|:||           |..
Zfish  3341 RS------PFALETLGEEKVQ-KILQLSQASSIAQVVEG----LQIQALEL-----------LRS 3383

  Fly  1572 LIVPGEEQITEWRNRPYKST--VWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPI 1634
            .....||:...: ::.:.:|  :...|.        .:|.|..:|::.:|..:|.:|..:.|   
Zfish  3384 AACKAEEEEQSF-SQQHVNTHGIVEAYM--------TMANFCDRRLRESEQKEEAISSKLQS--- 3436

  Fly  1635 AVCHIPE-ALKYLCTTKNLLQESPDLVY--ILSWSPVTPIQALAYFSRQYPSHP----------- 1685
                :|| .:|.:.....|..|...|.:  :|....|.|.:.|....|:..|.|           
Zfish  3437 ----LPEHVVKMMLKALKLSSEEARLKFPRLLQLVEVYPAETLDLMVREVVSVPCWLLIGWISQM 3497

  Fly  1686 ---------LTAQYAVKTLSS-YPAESVLPYI-----------------PQLVQALRH--DTMGY 1721
                     ...|:.::.::. ||...:.||:                 .:.|:.|..  |..|.
Zfish  3498 MALLDKPQATAVQHVIEEIAECYPQALIYPYMISSENYTFEESASGQRNREFVEKLESLLDKGGV 3562

  Fly  1722 VVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKD-PNLYEALDQLSQSIIASFSGAAK--RF 1783
            :..|:..:.:.|..       .|....:.||.:...| |||.:  .::....:....|.||  ||
Zfish  3563 IQGFVDALQQLSNP-------EMLFKDWWDEVKNQLDKPNLDK--KKMKLQYMTELLGDAKSPRF 3618

  Fly  1784 --YEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYL---------PSNPEAMV 1837
              |.|:|            |:.|:|.:|:   .|.|       ||..|         ....:.||
Zfish  3619 GSYRRKF------------IQKFSKEVEK---LLGA-------GGSKLYERRKDKDFLQQVDRMV 3661

  Fly  1838 LDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAM-EVSNNPNSQEDAKMTLGVESWQAA-- 1899
            ..:......|......:|:|:.|:..... .|||.... :..:.|..:..||:|...|..:..  
Zfish  3662 QSMRGFQKEPGNMKEYSPWLSSFKAETLK-NELEVPGQYDGKSKPLPEYHAKITGFDERVKVMTS 3725

  Fly  1900 -------------------IFKVGDDVRQDMLALQVITIFKNIFQQ----VGLDLFLFPYRVVAT 1941
                               :.|.|:|:|||....|:..:...|..|    ....|.|..|:|:..
Zfish  3726 IRRPKRIIIRGDDERDYPFLVKGGEDLRQDQRIEQLFGVMNMILSQDTACSQRSLALRTYQVIPI 3790

  Fly  1942 APGCGVIECVPN--------AKSRDQLGRQTDSGLSEYFQ-------------HQYGD------- 1978
            ....|:||.:.|        :..|.:..::|.:..:|::.             .:|.:       
Zfish  3791 TSRIGLIEWMENTCTLKDFLSSRRTEQEQKTITRPNEFYDEWISKVAGKVEGIRRYAELYKKAKR 3855

  Fly  1979 ---------------------------ESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIM 2016
                                       .:.:.|.:.|::|..|.|...:..::|.|.|||..|.|
Zfish  3856 VDTVNNFRRIEQMVPDDLLKRAFVRMSTTPEAFLSLRSHFSSSHAVLCISHWILGIGDRHLSNFM 3920

  Fly  2017 IDKD-GHIIHIDFGFMFESSPGGNIGFEP-----DMKLTDEMVMIMGGKMDSPAFKWFCELCVQA 2075
            |:.: |.:|.||||..|    |....|.|     ..:||.:.:.:|....:|...:   .:.|.:
Zfish  3921 INTETGGMIGIDFGHAF----GSATQFLPVPELMPFRLTRQFINLMRPLAESGLIQ---SVMVHS 3978

  Fly  2076 FLAVRPYQDAIVSLVSL---------------MLDTG-----------LPCFRGQTINLLKQRFV 2114
            ..|.|...|.:::.:.:               .|..|           :..|..|.:|..:::..
Zfish  3979 LRAFRAEPDLLLNTMDVFVKEPSLDWKNFELKQLKKGGTWTESVNTKEINWFPLQKVNFARRKLE 4043

  Fly  2115 ATKNNKEAAAH-------------MLAVIRNSYQ-NFRTRTYDMIQYYQNQI 2152
            .|..:...:..             :|||.|...| |.|.|..|.....::|:
Zfish  4044 GTNPSVITSEELCLGFEKMPEYKGLLAVARGEEQHNIRARLADKDLTVEDQV 4095

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 38/218 (17%)
PI4Kc_III_alpha 1836..2153 CDD:270711 82/444 (18%)
prkdcXP_009301676.1 NUC194 1830..2211 CDD:285387 25/151 (17%)
FAT 3070..3465 CDD:280429 85/475 (18%)
PIKKc_DNA-PK 3713..4006 CDD:270716 54/299 (18%)
FATC 4089..4119 CDD:280430 1/7 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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