Protein Alignment Pi4KIIIalpha and pik3c3

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: XP_021333200.1
• Gene: pik3c3 / 548346
• ZFINID: ZDB-GENE-050410-13
• Length: 887
• Species: Danio rerio
• Alignment Length: 829
• Identity: 188/829 - (22%)
• Similarity: 323/829 - (38%)
• Gaps: 228/829 - (27%)

  Fly  1429 LKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGN 1493
            ||.|..:..:... .||..|   .|::|::..||..:...|:..       :::|.|:: ...|:
Zfish   142 LKVWPGVEGDGTE-PTSTPG---RTSSSLAEDQMGRLAKGPDLE-------ILSDLTKA-HRQGH 194

  Fly  1494 AVGMGMGVAGGGSSSGWYNTIP-HSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAV-- 1555
            .|.:           .|.:.:. .....:::...||....|              |::|...|
Zfish   195 MVKV-----------DWLDRLTFREIEMINESEKRSSNFMY--------------LMVEFPRVKS 234

  Fly  1556 -ELEFLITWYNPNS-----LP---DLI-VPGE----EQITEWRN----------------RPYKS 1590
             |.|:.|.:|..::     ||   |:: ||..    |.:.|.::                :|..:
Zfish   235 GEREYSIVYYEKDADESSPLPTSSDIVKVPDPQMCMENLVESKHHKLARSLRSGPSDHDLKPNAA 299

  Fly  1591 TVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEAL-KYL-CTTKNLL 1653
            |  ||...:...|.|            .:.:..|...||......:....:|| |:| |...:|.
Zfish   300 T--RDQLNIIVSYPP------------TKQLSSEEQDLVWKFRYYLTTQEKALTKFLKCVNWDLP 350

  Fly  1654 QESPDLVYIL-SWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRH- 1716
            ||:...:.:| .|.|:....:|...|.|: ::|...:|||..|.....|.:|.|:.||||||::
Zfish   351 QEAKQALELLGKWRPMDVEDSLELLSSQF-TNPTVRRYAVARLQQADDEDLLMYLLQLVQALKYE 414

  Fly  1717 ---------------DTMGYVVE----------------------------------------FI 1726
                           |..|.:.|                                        |:
Zfish   415 NFNDIQGGLEPANKRDNQGGLTESSTTGDLDSSQLASAIAVMPSSQKGKEGTDGENLEQDLCTFL 479

  Fly  1727 KNISRRSQIVAHQLIWNMQTNMYM-----DEDQQHKDPNLYE----ALDQLSQS---------II 1773
            .:.:.::..:|:.|.|      |:     |:|.|.:||..::    .:.:.||:         ::
Zfish   480 ISRACKNSTLANYLYW------YVIVECEDQDTQQRDPKTHDMYLNVMRRFSQALLKGDKSVRVM 538

  Fly  1774 ASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQ--GGCYLPSNPEAM 1836
            .|...:.:.|.:|.......:...||..:   |..||..:.||...::.:.  ....||..|:..
Zfish   539 RSLLASQQTFVDRLVQLMKAVQRESGNRK---KKTERLQSLLADNEKVNLSEIEPIPLPLEPQIR 600

  Fly  1837 VLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQ--AA 1899
            :..|...:.|..:||..                                .||:....|..:  ..
Zfish   601 IKGIIPETATLFKSALM--------------------------------PAKLIFKTEDGEQYPV 633

  Fly  1900 IFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQT 1964
            |||.|||:|||.|.||:|::...:.::..|||.|.||:|:||:...|.::.|.:....:.|.  |
Zfish   634 IFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFVQSVPVAEVLA--T 696

  Fly  1965 DSGLSEYFQH-------QYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGH 2022
            :..:..:|:.       .||..|.     ....:|||.|.|.:|.|:|.:.|||..|:::.|.|.
Zfish   697 EGNIQSFFRKYAPNDKGPYGISSE-----VMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGK 756

  Fly  2023 IIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIV 2087
            :.|||||::....|.   ...|.|||:.|||..||| |.|..::.|.:.|..|||.:|.|.:.|:
Zfish   757 LFHIDFGYILGRDPK---PLPPPMKLSKEMVEGMGG-MQSEQYQEFRKQCYTAFLHLRRYSNLIL 817

  Fly  2088 SLVSLMLDTGLPCFR---GQTINLLKQRFVATKNNKEAAAHMLAVIRNS 2133
            :|.|||:|..:|...   .:|:..::.:|....:::||..:|.::|..|
Zfish   818 NLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDES 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	48/251 (19%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	90/310 (29%)
pik3c3	XP_021333200.1	C2_PI3K_class_III	25..194	CDD:176042	13/63 (21%)
		PI3Ka_III	291..503	CDD:238442	45/232 (19%)
		PI3Kc_III	539..883	CDD:270628	103/374 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810