Protein Alignment Pi4KIIIalpha and PI4KB

DIOPT Version :10

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: XP_011507936.1
• Gene: PI4KB / 5298
• HGNCID: 8984
• Length: 849
• Species: Homo sapiens
• Alignment Length: 884
• Identity: 208/884 - (23%)
• Similarity: 342/884 - (38%)
• Gaps: 252/884 - (28%)

  Fly  1442 LVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMS-ASGNAVG--------- 1496
            ::|..||:..:.:..|:..   |.:...|...|:.||..|:.....:. .:|:.|.
Human    44 VITEGVGELSVIDPEVAQK---ACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDP 105

  Fly  1497 ----------MGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILE 1551
                      ||..||.|                    :.:..|.:.|.:|..:.::.:   :.|
Human   106 PAQIREEEDEMGAAVASG--------------------TAKGARRRRQNNSAKQSWLLR---LFE 147

  Fly  1552 LLAVELEFLITW-YNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCY-NPALAVFLPQR 1614
            ....::...|:: ||...      ||.:...  .||             .:|: |..:..:|||.
Human   148 SKLFDISMAISYLYNSKE------PGVQAYI--GNR-------------LFCFRNEDVDFYLPQL 191

  Fly  1615 IKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILS--WSPVTPIQALAYF 1677
            :.....:||:|...:  .|..|....:::.:......||......::|.:  .|..|.::.|...
Human   192 LNMYIHMDEDVGDAI--KPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILS 254

  Fly  1678 SRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIW 1742
            ....|:|   .:..:.:||..|...:.|                    .|...:||:..|...|
Human   255 DELKPAH---RKRELPSLSPAPDTGLSP--------------------SKRTHQRSKSDATASI- 295

  Fly  1743 NMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKG 1807
            ::.:|:....... |..|..|.|...::||..|||...:...|||  |...:.|:...:.:....
Human   296 SLSSNLKRTASNP-KVENEDEELSSSTESIDNSFSSPVRLAPERE--FIKSLMAIGKRLATLPTK 357

  Fly  1808 IERKNACLAALSRI--KVQGGCYLP-SNPEAMVLDIDYSSGTPMQSAAKAPYLA----------- 1858
            .::....::.||.:  |:....:|| :..:..|:.:.::....:.|..|||||.
Human   358 EQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFD 422

  Fly  1859 -----------RFRVYR-------CGITELETRAMEVSNNPN----------------------- 1882
                       |.|..|       ||||. |.||...|..||
Human   423 TTSVPARIPENRIRSTRSVENLPECGITH-EQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEV 486

  Fly  1883 -----------------SQE----------DAKMTLG----------------------VESWQ- 1897
                             |||          |.:..|.                      .|.||
Human   487 HTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQE 551

  Fly  1898 --------------------AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATA 1942
                                :.|.|.|||:||::||.||:...::|::|..:.|::.||:::..:
Human   552 KVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVIS 616

  Fly  1943 PGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQI 2007
            ...|:||.|.||.|..|:.:|:...|.:||..::|..:::.|.:|:.|||:|.|.|.|:.||||:
Human   617 ADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQV 681

  Fly  2008 KDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPD-MKLTDEMVMIMGGKMDSPAFKWFCEL 2071
            ||||||||::|.:||||||||||:..||| .|:|||.. .|||.|.|.:||| :|...|.::..|
Human   682 KDRHNGNILLDAEGHIIHIDFGFILSSSP-RNLGFETSAFKLTTEFVDVMGG-LDGDMFNYYKML 744

  Fly  2072 CVQAFLAVRPYQDAIVSLVSLM----------------------LDTGLPCFRG-QTINLLKQRF 2113
            .:|..:|.|.:.|.:|.:|.:|                      :.:.||||.| .||..||:||
Human   745 MLQGLIAARKHMDKVVQIVEIMQQGCRRCSGSSPSGPMMTVAQVICSQLPCFHGSSTIRNLKERF 809

  Fly  2114 VATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQNQI 2152
            ..:...::....:..::..|.::..|:.||..||..|.|
Human   810 HMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGI 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	24/149 (16%)
		PI4Ka	1600..1775	CDD:238443	34/177 (19%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	133/463 (29%)
PI4KB	XP_011507936.1	PI4KB_NTD	14..78	CDD:412074	8/36 (22%)
		PI4Kc_III_beta	541..849	CDD:270712	108/310 (35%)