Protein Alignment Pi4KIIIalpha and PI4KA

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_477352.3
• Gene: PI4KA / 5297
• HGNCID: 8983
• Length: 2102
• Species: Homo sapiens
• Alignment Length: 2214
• Identity: 992/2214 - (44%)
• Similarity: 1355/2214 - (61%)
• Gaps: 212/2214 - (9%)

  Fly    11 YQRTVLCLARVLAGIQPTPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFLEGGCQHEG 75
            |..|||.|||.||..:|...:|||.|...||.: ..|:|.||.|.:||||||||:.:|...||:.
Human    31 YFNTVLSLARSLAVQRPASLEKVQKLLCMCPVD-FHGIFQLDERRRDAVIALGIFLIESDLQHKD 94

  Fly    76 QIVPYLLRLAKCLPKAVWIDDARSNKVERVRIPSAEKFSFCLNTLLSDIAAKCPDSREEIILNQV 140
            .:|||||||.|.|||..|::::.:.| .|..:|.||.|||||.|||||:|.:.|..|:||:
Human    95 CVVPYLLRLLKGLPKVYWVEESTARK-GRGALPVAESFSFCLVTLLSDVAYRDPSLRDEIL---- 154

  Fly   141 ETLSALANIVKSSRDSSSAPPPIILCKATVPLLFGLARSMGRYASNDPPLLCRIF---PPELLPI 202
            |.|..:.:::.....:........|||..:|.|.|::|:.|||::.:..||.::|   ||..|.:
Human   155 EVLLQVLHVLLGMCQALEIQDKEYLCKYAIPCLIGISRAFGRYSNMEESLLSKLFPKIPPHSLRV 219

  Fly   203 QKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSM------------SGSLAQAQNA 255
            .:           ...|....||:.         ||.|:|.::            :.|::.....
Human   220 LE-----------ELEGVRRRSFND---------FRSILPSNLLTVCQEGTLKRKTSSVSSISQV 264

  Fly   256 SYDDGRQRCAGGKPSKP--SLHSYFSVPYDP------RTHFFTRYGSSFNQFPNMRVCESPTKGG 312
            |.:.|..     .||.|  |...||.....|      ..::|:...|||:        .||...|
Human   265 SPERGMP-----PPSSPGGSAFHYFEASCLPDGTALEPEYYFSTISSSFS--------VSPLFNG 316

  Fly   313 PRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVT 377
              ..|:....|::.|:.:..:.||::.:..|:.||...:.:...:......|.|||:.|.|.:..
Human   317 --VTYKEFNIPLEMLRELLNLVKKIVEEAVLKSLDAIVASVMEANPSADLYYTSFSDPLYLTMFK 379

  Fly   378 LLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMAN 442
            :||:.|.:..||||.|.|::.:||...|...|.|||....|.:|...|      ::..|:...||
Human   380 MLRDTLYYMKDLPTSFVKEIHDFVLEQFNTSQGELQKILHDADRIHNE------LSPLKLRCQAN 438

  Fly   443 AACVDLLVWAIRDETVDVDYNVPSLQNGLQFLLKKEADKLCGRLSQKLNLELSHKIVMDHMPLLM 507
            ||||||:|||::||                    :.|:.||.:||:||..:.|.|:::.|:|||:
Human   439 AACVDLMVWAVKDE--------------------QGAENLCIKLSEKLQSKTSSKVIIAHLPLLI 483

  Fly   508 VCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAV--Q 570
            .||:|||:|..:||.:..:....||||||.|||:|.||:.:..|.......:     .||:|  :
Human   484 CCLQGLGRLCERFPVVVHSVTPSLRDFLVIPSPVLVKLYKYHSQYHTVAGND-----IKISVTNE 543

  Fly   571 HSDSRTAVVIYGDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSN 635
            ||:| |..|:.|...:|          :.:|.|||.||:|:...|:|..|:|...|.|.:|::||
Human   544 HSES-TLNVMSGKKSQP----------SMYEQLRDIAIDNICRCLKAGLTVDPVIVEAFLASLSN 597

  Fly   636 RLFTAEKSGSESQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQNAL 700
            ||:.:::|..:       ::|:..:.|..|||:||||:||.|..:.|||...|:||:.||..:.|
Human   598 RLYISQESDKD-------AHLIPDHTIRALGHIAVALRDTPKVMEPILQILQQKFCQPPSPLDVL 655

  Fly   701 IVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQ-FHHVSDAVVNALGNIAAN 764
            |:|||||::|:. ..:::.|:..:|.:::|:::|:.|::..:::.. :.|.|.||:|||.|||||
Human   656 IIDQLGCLVITG-NQYIYQEVWNLFQQISVKASSVVYSATKDYKDHGYRHCSLAVINALANIAAN 719

  Fly   765 IQGDAEMLELLGKLLELFVQIGLDG----ERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRLPP 825
            ||.:..:.|||..|||||||:||:|    ||:.:..| |.||||.|||||:||||||||.|||||
Human   720 IQDEHLVDELLMNLLELFVQLGLEGKRASERASEKGP-ALKASSSAGNLGVLIPVIAVLTRRLPP 783

  Fly   826 IKNPRQRLHKLFKDFWAYCVVMGFT--NARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRE-LN 887
            ||..:.||.|||:|||.|.|:|||.  .:.|||.:||:||.:||.|||||...:  |..:|. |.
Human   784 IKEAKPRLQKLFRDFWLYSVLMGFAVEGSGLWPEEWYEGVCEIATKSPLLTFPS--KEPLRSVLQ 846

  Fly   888 YTLAIKSDSV-----NELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENADEP 947
            |..|:|:|:|     :||||.|:.||:...: |:..||||.||..|||||||.||.:||..:.:|
Human   847 YNSAMKNDTVTPAELSELRSTIINLLDPPPE-VSALINKLDFAMSTYLLSVYRLEYMRVLRSTDP 910

  Fly   948 SLEPIM-SYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVL--YAHDEIREKVLESQATLLLVYF 1009
            ....:| .|..|.|:|:||:|:.|||..|||:||:.|.|::  .|..:..|:.||..|..|||.|
Human   911 DRFQVMFCYFEDKAIQKDKSGMMQCVIAVADKVFDAFLNMMADKAKTKENEEELERHAQFLLVNF 975

  Fly  1010 NHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYT 1074
            |||||.|:.|||:|||.|||:||||||:..||..||||||.|:.|||.|.:::.|...:...||.
Human   976 NHIHKRIRRVADKYLSGLVDKFPHLLWSGTVLKTMLDILQTLSLSLSADIHKDQPYYDIPDAPYR 1040

  Fly  1075 LQLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPV--LAHHSGLALAFD 1137
            :.:.|:..|||..:||||.||..|:.|||||||..|:||||||.|:....|  |:.|:|||:|.:
Human  1041 ITVPDTYEARESIVKDFAARCGMILQEAMKWAPTVTKSHLQEYLNKHQNWVSGLSQHTGLAMATE 1105

  Fly  1138 SVV---SSSAQHT----GTMSKRPSCVNSDTPRFVSVLCLRSKYAGEI------SGLLSVLSEKD 1189
            |::   ..:.|:|    ..:|:||:||..|...|::.|.||::||||:      ||....:|:.:
Human  1106 SILHFAGYNKQNTTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGTTGQMSDLN 1170

  Fly  1190 KAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETA 1254
            |     .:|.|:..|........:..|:::.||.||...:...:|||.:....|.:|.|..||||
Human  1171 K-----MMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDCDPQLLHHLCWGPLRMFNEHGMETA 1230

  Fly  1255 VECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPH 1319
            :.||:|:|..:..:|:.|::||..||..|.|::.|||:.|.:...||||.|..:....|..:.||
Human  1231 LACWEWLLAGKDGVEVPFMREMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTPH 1295

  Fly  1320 LIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPV----LKSSKQNRQVSTVGCRFKLLQCGLSL 1380
            .||:..|.:..:.||||:.|:||:|..||.|.:.:    .|.| .||.|:.:|.|||||..||||
Human  1296 YIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGS-MNRHVAAIGPRFKLLTLGLSL 1359

  Fly  1381 LQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTS 1445
            |..:.:|.:..||:|||:|||.|.|||..||..|.|..::|.|||.|::|||..|.|:||:|..|
Human  1360 LHADVVPNATIRNVLREKIYSTAFDYFSCPPKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTAS 1424

  Fly  1446 EVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGG---SS 1507
            ::...|                              |..|||          .:.:..|.   ::
Human  1425 QLVPPD------------------------------NQDTRS----------NLDITVGSRQQAT 1449

  Fly  1508 SGWYNTIPHST--STLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLP 1570
            .||.||.|.|:  ||:||:|..||:.. :.....|.|||:|.|:|.|||.|:|.|||||||.|.|
Human  1450 QGWINTYPLSSGMSTISKKSGMSKKTN-RGSQLHKYYMKRRTLLLSLLATEIERLITWYNPLSAP 1513

  Fly  1571 DLIV--PGEEQITEWRNR--PYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCS 1631
            :|.:  .||..:..||::  ......|:|...|||..:|.|||.||.|.||.|.|..||:|||..
Human  1514 ELELDQAGENSVANWRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVTRLVRL 1578

  Fly  1632 DPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLS 1696
            ||.||..:|||:|:|.|...:..::|:|.::|.|:|..|...|:|||..||.|||||||.||.|.
Human  1579 DPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHPLTAQYGVKVLR 1643

  Fly  1697 SYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNL 1761
            |:|.:::|.||||:|||||:|.||||.|:|...:.:||::|||.||||:||:|:||:...|||::
Human  1644 SFPPDAILFYIPQIVQALRYDKMGYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDI 1708

  Fly  1762 YEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKVQGG 1826
            .:.||||.:.|..|.||.||.||:||||||.|||.||..|:.:.||.|||.|||:|||.:|||.|
Human  1709 GDLLDQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKKACLSALSEVKVQPG 1773

  Fly  1827 CYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTL 1891
            |||||||||:||||||.|||||||||||||||:|:|.|||::|||...:...::...:...:...
Human  1774 CYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLRCRSDSEDECSTQEAD 1838

  Fly  1892 GVE-SWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAK 1955
            |.: ||||||||||||.||||||||:|.:||||||.||||||:|||||||||||||||||:|:..
Human  1839 GQKISWQAAIFKVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCT 1903

  Fly  1956 SRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKD 2020
            ||||||||||.|:.:||..||||||:..||.||.||::|||||||:.:|||||||||||||:||.
Human  1904 SRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKK 1968

  Fly  2021 GHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDA 2085
            |||||||||||||||||||:|:|||:||||||||||||||::..||||.|:||:.:||||||.||
Human  1969 GHIIHIDFGFMFESSPGGNLGWEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDA 2033

  Fly  2086 IVSLVSLMLDTGLPCFRGQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQN 2150
            :||||:|||||||||||||||.|||.||......:|||..::.||::.:.:.|:|||||||||||
Human  2034 VVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQSCFLSNRSRTYDMIQYYQN 2098

  Fly  2151 QIPY 2154
            .|||
Human  2099 DIPY 2102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	91/174 (52%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	221/317 (70%)
PI4KA	NP_477352.3	PI4Ka	1547..1722	CDD:238443	91/174 (52%)
		PI4Kc_III_alpha	1783..2101	CDD:270711	221/317 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143479
Domainoid	1	1.000	1000	1.000	Domainoid score	I30
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11171
Inparanoid	1	1.050	1698	1.000	Inparanoid score	I76
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60094
OrthoDB	1	1.010	-	-		D1147978at2759
OrthoFinder	1	1.000	-	-		FOG0002854
OrthoInspector	1	1.000	-	-		oto90195
orthoMCL	1	0.900	-	-		OOG6_101741
Panther	1	1.100	-	-	LDO	PTHR10048
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4430
SonicParanoid	1	1.000	-	-		X2686
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840