DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and PIK3CG

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_001269355.1 Gene:PIK3CG / 5294 HGNCID:8978 Length:1102 Species:Homo sapiens


Alignment Length:853 Identity:192/853 - (22%)
Similarity:336/853 - (39%) Gaps:211/853 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1359 KQNRQVSTVG---C--RFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSR 1418
            |.:..|.||.   |  :|::...|:.:   ..:|::....:..|....:.....|...|.|....
Human   344 KDHESVFTVSLWDCDRKFRVKIRGIDI---PVLPRNTDLTVFVEANIQHGQQVLCQRRTSPKPFT 405

  Fly  1419 EQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQM-------LAVRNNPETASLIS 1476
            |::|.::      |.....:.|          ||...::.:.|:       |:.:.:.|:.|..|
Human   406 EEVLWNV------WLEFSIKIK----------DLPKGALLNLQIYCGKAPALSSKASAESPSSES 454

  Fly  1477 GGG---------LVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQ 1532
            .|.         |:.|: |.:...|..|.....::|.|...|.:|....:::|...:.| |..:.
Human   455 KGKVQLLYYVNLLLIDH-RFLLRRGEYVLHMWQISGKGEDQGSFNADKLTSATNPDKEN-SMSIS 517

  Fly  1533 YQKDSY-------------DKDYMKKRNLILELLAVELEFLIT---------------WY----- 1564
            ...|:|             |.:..:.|..:...|..:||.:|.               |:     
Human   518 ILLDNYCHPIALPKHQPTPDPEGDRVRAEMPNQLRKQLEAIIATDPLNPLTAEDKELLWHFRYES 582

  Fly  1565 --NPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSR 1627
              :|.:.|.|.     ...:|..:...:..::..||.......||.|.|..::.:....||.|..
Human   583 LKHPKAYPKLF-----SSVKWGQQEIVAKTYQLLARREVWDQSALDVGLTMQLLDCNFSDENVRA 642

  Fly  1628 LVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAV 1692
            :                                                              ||
Human   643 I--------------------------------------------------------------AV 645

  Fly  1693 KTLSSYPAESVLPYIPQLVQALR----HDTMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDED 1753
            :.|.|...:.||.|:.|||||::    ||:.  :..|:.....|::.:.|.|.|.:::.:.....
Human   646 QKLESLEDDDVLHYLLQLVQAVKFEPYHDSA--LARFLLKRGLRNKRIGHFLFWFLRSEIAQSRH 708

  Fly  1754 QQHKDPNLYEA-LDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAA 1817
            .|.:...:.|| |.....:::..|:        ::......:..|:.:|:|.:  .|:.:.....
Human   709 YQQRFAVILEAYLRGCGTAMLHDFT--------QQVQVIEMLQKVTLDIKSLS--AEKYDVSSQV 763

  Fly  1818 LSRIKVQ----GGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITE-------LE 1871
            :|::|.:    ....||.           |...|.....||..||   :.:|.:..       ||
Human   764 ISQLKQKLENLQNSQLPE-----------SFRVPYDPGLKAGALA---IEKCKVMASKKKPLWLE 814

  Fly  1872 TRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPY 1936
            .:..:.:...|.      |:|:      |||.|||:|||||.||::.|.::|::...|||.|.||
Human   815 FKCADPTALSNE------TIGI------IFKHGDDLRQDMLILQILRIMESIWETESLDLCLLPY 867

  Fly  1937 RVVATAPGCGVIECVPNAKSRDQLGRQT--DSGL--SEYFQHQYGDESSKE--FQAARANFVKSM 1995
            ..::|....|:||.|.:|.:..::.:.|  ::|.  .|...|...::|..|  ||||...||.|.
Human   868 GCISTGDKIGMIEIVKDATTIAKIQQSTVGNTGAFKDEVLNHWLKEKSPTEEKFQAAVERFVYSC 932

  Fly  1996 AAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFM---FESSPGGNIGFEPDMKLTDEMVMIMG 2057
            |.|.:..::|.|.||||.||||.:.|::.|||||.:   ::|..|.|....| ..||.:.:.:||
Human   933 AGYCVATFVLGIGDRHNDNIMITETGNLFHIDFGHILGNYKSFLGINKERVP-FVLTPDFLFVMG 996

  Fly  2058 --GKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRG-QTINLLKQRFVATKNN 2119
              ||..||.|:.|.::||:|:||:|.:.:.::.|.|:||.||:|.... :.|..::......||.
Human   997 TSGKKTSPHFQKFQDICVKAYLALRHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKNE 1061

  Fly  2120 KEAAAHML 2127
            ::|..:.|
Human  1062 EDAKKYFL 1069

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 30/179 (17%)
PI4Kc_III_alpha 1836..2153 CDD:270711 102/311 (33%)
PIK3CGNP_001269355.1 PI3K_rbd 203..312 CDD:197540
C2_PI3K_class_I_gamma 350..527 CDD:176044 36/197 (18%)
PI3Ka_I 549..725 CDD:238444 41/244 (17%)
PI3Kc_IB_gamma 729..1095 CDD:270627 111/378 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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