DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and PIK3CA

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	NP_006209.2	Gene:	PIK3CA / 5290	HGNCID:	8975	Length:	1068	Species:	Homo sapiens

Alignment Length:	1000	Identity:	210/1000 - (21%)
Similarity:	376/1000 - (37%)	Gaps:	288/1000 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1261 VLTARQDLELC-------FIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYE---GCKLVSKP-- 1313
            :|.:.:.|:||       :|.::....:...||            :||:.|:   .|.::.:.
Human   232 MLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEK------------YPLSQYKYIRSCIMLGRMPN 284

  Fly  1314 -ILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVL--KSSKQNRQVSTVGCRFKLLQ 1375
             :|:|...::.||..:......|..|         :....|.:  ::|.::..|.....|.|:|
Human   285 LMLMAKESLYSQLPMDCFTMPSYSRR---------ISTATPYMNGETSTKSLWVINSALRIKIL- 339

  Fly  1376 CGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQS-----------REQLLEDIMILL 1429
            |.       |......|:|  ::||.....|..|.|.|.|.:           .|.|..||.|
Human   340 CA-------TYVNVNIRDI--DKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYI-- 393

  Fly  1430 KFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRN----NPETASLISGGGLVNDYTRSMSA 1490
                                .||..|:.....:.:|:.    ..|...|..|...:.|||.::.:
Human   394 --------------------PDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVS 438

  Fly  1491 SGNAVGM------------GMGVAGGGSSS---------GWYNTI----------PHSTSTLSKR 1524
            ...|:.:            .:||.|...:.         .|::::          .|:..::|:.
Human   439 GKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSRE 503

  Fly  1525 ----------SNRSKRLQYQKDSYDKDYMK---KRNLILELLAVELEFLITWYN-------PNSL 1569
                      |||..|....::: ||:.:|   .|:.:.|:...|.:||  |.:       |..|
Human   504 AGFSYSHAGLSNRLARDNELREN-DKEQLKAISTRDPLSEITEQEKDFL--WSHRHYCVTIPEIL 565

  Fly  1570 PDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPI 1634
            |.|::.     .:|.:|                                    :||:::.|
Human   566 PKLLLS-----VKWNSR------------------------------------DEVAQMYC---- 585

  Fly  1635 AVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYP 1699
                                      .:..|.|:.|.||:......||. |:...:||:.|..|.
Human   586 --------------------------LVKDWPPIKPEQAMELLDCNYPD-PMVRGFAVRCLEKYL 623

  Fly  1700 AESVL-PYIPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNL 1761
            .:..| .|:.||||.|:::..  ..:|.|:...:..:|.:.|...|::::.|:
Human   624 TDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMH------------ 676

  Fly  1762 YEALDQLSQSIIASFSGAAKRFYE---REFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKV 1823
            .:.:.|....::.|:..|...:.:   |:.:...|:..::..::.     |:|:.......:..|
Human   677 NKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQ-----EKKDETQKVQMKFLV 736

  Fly  1824 Q-----------GGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEV 1877
            :           .|...|.||                    |..|...|:..|.|.....|.:.:
Human   737 EQMRRPDFMDALQGFLSPLNP--------------------AHQLGNLRLEECRIMSSAKRPLWL 781

  Fly  1878 S-NNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVAT 1941
            : .||    |....|..:: ...|||.|||:|||||.||:|.|.:||:|..||||.:.||..::.
Human   782 NWENP----DIMSELLFQN-NEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSI 841

  Fly  1942 APGCGVIECVPNAKSRDQLGRQTDSGLSEYFQ------HQYGDESSKE--FQAARANFVKSMAAY 1998
            ....|:||.|.|:.:..|:  |...||....|      ||:..:.:|.  :.||...|.:|.|.|
Human   842 GDCVGLIEVVRNSHTIMQI--QCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGY 904

  Fly  1999 SLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFE----PDMKLTDEMVMIMGGK 2059
            .:..::|.|.||||.|||:..||.:.|||||...:... ...|::    |.:...|.:::|..|.
Human   905 CVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKK-KKFGYKRERVPFVLTQDFLIVISKGA 968

  Fly  2060 MD---SPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRG-QTINLLKQRFVATKNNK 2120
            .:   :..|:.|.|:|.:|:||:|.:.:..::|.|:||.:|:|..:. ..|..:::.....|..:
Human   969 QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQ 1033

  Fly  2121 EAAAHMLAVIRNSYQNFRTRTYDMI 2145
            ||..:.:..:.:::....|...|.|
Human  1034 EALEYFMKQMNDAHHGGWTTKMDWI 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	29/177 (16%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	94/326 (29%)
PIK3CA	NP_006209.2	PI3K_p85B	32..107	CDD:396665
		PI3K_rbd	173..292	CDD:197540	13/71 (18%)
		C2_PI3K_class_I_alpha	325..484	CDD:176043	35/190 (18%)
		PI3Ka_I	525..696	CDD:238444	46/257 (18%)
		PI3Kc_IA_alpha	695..1064	CDD:270719	103/396 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810