Protein Alignment Pi4KIIIalpha and PIK3C2G

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: XP_016874959.1
• Gene: PIK3C2G / 5288
• HGNCID: 8973
• Length: 1492
• Species: Homo sapiens
• Alignment Length: 1377
• Identity: 292/1377 - (21%)
• Similarity: 504/1377 - (36%)
• Gaps: 396/1377 - (28%)

  Fly   991 DEIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSL 1055
            :|..||..|.| ..|.|...|....:.:..||.:..:..:.||                   |..
Human    12 NESHEKQYEHQ-EFLFVNQPHSSSQVSLGFDQIVDEISGKIPH-------------------YES 56

  Fly  1056 SLDPNEETPTLRVVSTPYTLQLMDSL-PARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPN 1119
            .:|.|    |..|.:.|.......|| .|.::.|.:|..:     :..:.|...|....:...|:
Human    57 EIDEN----TFFVPTAPKWDSTGHSLNEAHQISLNEFTSK-----SRELSWHQVSKAPAIGFSPS 112

  Fly  1120 QIP------------TPVLAHH-------SGLALAFDSVVSSSAQ----------HTGTMSKRPS 1155
            .:|            :|:..||       |.||.:|.|:...:.:          |.|..|..|.
Human   113 VLPKPQNTNKECSWGSPIGKHHGADDSRFSILAPSFTSLDKINLEKELENENHNYHIGFESSIPP 177

  Fly  1156 CVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEACAEKSDARHRGALWRA 1220
            ..:|.:..|:      .|...:.||.:::: |.....|...|...:||            :.|:.
Human   178 TNSSFSSDFM------PKEENKRSGHVNIV-EPSLMLLKGSLQPGMWE------------STWQK 223

  Fly  1221 TAYLIICSEISRKLLHAVASSQLEL--FTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTT 1283
            ....|.|   |.:|:....||...|  |.....:                    |:|...|....
Human   224 NIESIGC---SIQLVEVPQSSNTSLASFCNKVKK--------------------IRERYHAADVN 265

  Fly  1284 FEKRMGLFAWETEVTHPLAAYEGCKL--------VSKPILIAPHLIWL--QLLSEMVDTAKYCNR 1338
            |....   .|.|....|...:...|.        .::|:...|...:|  .|::|::   .:|..
Human   266 FNSGK---IWSTTTAFPYQLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLIAEIL---HFCTN 324

  Fly  1339 DKV------------EMF-----CLLLHRCLPVLKS-------------SKQNRQVSTVGCRFKL 1373
            |::            |.|     ||..|:.....||             .|.:|:......:|.|
Human   325 DQLLPKDHILSVCGSEEFLQNDHCLGSHKMFQKDKSVIQLHLQKSREAPGKLSRKHEEDHSQFYL 389

  Fly  1374 -------------LQCGLSLLQGNTIP-KSLSRNILRERIYS--NALDYFCGPPTC--PNQSREQ 1420
                         .||.|:|::..... |.|.:.  :|.:|:  ..:...|....|  ..|..:.
Human   390 NQLLEFMHIWKVSRQCLLTLIRKYDFHLKYLLKT--QENVYNIIEEVKKICSVLGCVETKQITDA 452

  Fly  1421 LLEDIMILLK----FWQTMRSEKKHL---VTSEVGD--YDLTNASVSS--TQMLAVRNNPETASL 1474
            :.|..:||.:    |:|:..:..|.|   ||:|:..  |.|.|...:|  .....| |.|...|.
Human   453 VNELSLILQRKGENFYQSSETSAKGLIEKVTTELSTSIYQLINVYCNSFYADFQPV-NVPRCTSY 516

  Fly  1475 ISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIP----HS------TSTLSKRSNRSK 1529
            :: .||.:..:.::.|:.|                    ||    ||      |..|:....:..
Human   517 LN-PGLPSHLSFTVYAAHN--------------------IPETWVHSYKAFSFTCWLTYAGKKLC 560

  Fly  1530 RLQYQKDSYDK-------DYMKKRNLILELLAVELEFLIT-----------------WYNPNSLP 1570
            :::..::..||       ::.:..|..||:.::..|.::|                 |   ..||
Human   561 QVRNYRNIPDKKLFFFLVNWNETINFPLEIKSLPRESMLTVKLFGIACATNNANLLAW---TCLP 622

  Fly  1571 ------------------------DLIVPGEEQITEWRNRPYKSTVWRDYARLAWCY-NPALAVF 1610
                                    ::|.||...:::    |...|:..|:....|.| .|
Human   623 LFPKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQ----PSPVTLQIDFPATGWEYMKP----- 678

  Fly  1611 LPQRIKNAEIIDEEVSRLVCSDPIAVC--HI-------------PEALKYL------CTTKN--- 1651
                       |.|.:|....:|:..|  ||             .|..:||      |..:|
Human   679 -----------DSEENRSNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSL 732

  Fly  1652 --LLQESP--------DLVYIL-SWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLP 1705
              :|..:|        ::..|| .|:...|::||...:..:|...: .:.||:.|.:...:.:|.
Human   733 PLVLGSAPGWDERTVSEMHTILRRWTFSQPLEALGLLTSSFPDQEI-RKVAVQQLDNLLNDELLE 796

  Fly  1706 YIPQLVQALRHD--TMGYVVEFIKNISRRSQIVAHQLIW---NMQTNMYMDEDQQHKDPNLYEAL 1765
            |:||||||::.:  ....:|:.:.:.|.:|..|||:|.|   |.:...|.        .:.|
Human   797 YLPQLVQAVKFEWNLESPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYF--------KSWY--- 850

  Fly  1766 DQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGI---ERKNACLAALSRIKV---- 1823
                |.::|:....|.:....||....|:..:.|:|....|..   :|:......:.|::.
Human   851 ----QKLLAALQFCAGKALNDEFSKEQKLIKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQD 911

  Fly  1824 QGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAK 1888
            ...|:||.||...:..||:.:.:...|.|                 |..:...::.||..:.
Human   912 VNTCHLPLNPALCIKGIDHDACSYFTSNA-----------------LPLKITFINANPMGKN--- 956

  Fly  1889 MTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPN 1953
                    .:.|||.|||:|||||.||:|.:..||:.|.|||:.:..||.::|....|:::.||:
Human   957 --------ISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRCLSTGKDQGLVQMVPD 1013

  Fly  1954 AKSRDQLGRQT-------DSGLSEYF-QHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDR 2010
            |.:..::.|.:       ::.:.::| ||.:   ...:::.|..||..|.|.:.::.::|.:.||
Human  1014 AVTLAKIHRHSGLIGPLKENTIKKWFSQHNH---LKADYEKALRNFFYSCAGWCVVTFILGVCDR 1075

  Fly  2011 HNGNIMIDKDGHIIHIDFG-FMFESSPGGNIGFEPDMK---LTDEMVMIM--GGKMDSPAFKWFC 2069
            ||.|||:.|.||:.||||| |:..:...|  |.:.|..   .|.||...:  ||| :...|:.|.
Human  1076 HNDNIMLTKSGHMFHIDFGKFLGHAQTFG--GIKRDRAPFIFTSEMEYFITEGGK-NPQHFQDFV 1137

  Fly  2070 ELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRG-QTINLLKQRFVATKNNKEAAAHMLAVIRNS 2133
            |||.:|:..:|.:...:::|:.:||..|||...| |.:..:.........:.||.:|....|:.|
Human  1138 ELCCRAYNIIRKHSQLLLNLLEMMLYAGLPELSGIQDLKYVYNNLRPQDTDLEATSHFTKKIKES 1202

  Fly  2134 YQNFRTRTYDMI 2145
            .:.|..:..::|
Human  1203 LECFPVKLNNLI 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	47/215 (22%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	91/325 (28%)
PIK3C2G	XP_016874959.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810