DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and PIK3C2B

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	NP_001364263.1	Gene:	PIK3C2B / 5287	HGNCID:	8972	Length:	1634	Species:	Homo sapiens

Alignment Length:	1285	Identity:	261/1285 - (20%)
Similarity:	446/1285 - (34%)	Gaps:	408/1285 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   903 QILVLLEHSSDNVATAINKLSFAQC-----TYLLSVYWLEMLRVENADEPSLEPI-------MSY 955
            ::..:.|...:.||...:.|...:.     .|.|:.|      |.:|..||.|.:       ::.
Human   324 ELFEVSEERDEEVAAFCHMLDILRSGSDIQDYFLTGY------VWSAVTPSPEHLGDEVNLKVTV 382

  Fly   956 LCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVA 1020
            ||| .||...|....|...|...:::   .:.|.||::|.          :...:.:.||..:.
Human   383 LCD-RLQEALTFTCNCSSTVDLLIYQ---TLCYTHDDLRN----------VDVGDFVLKPCGLE- 432

  Fly  1021 DQYLSFLVDRFPHLLWNRR-VLWCM---LDI-LQLLAY-----SLSLDPNEETPTLRVVSTPYTL 1075
                .||.::  |.|.:.. :.:|.   :|| |||:..     .|:...|::       .:|.||
Human   433 ----EFLQNK--HALGSHEYIQYCRKFDIDIRLQLMEQKVVRSDLARTVNDD-------QSPSTL 484

  Fly  1076 QLMDSLPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVV 1140
            ..:..|..|.::        |.|..:|:...       ...|.|::...:|| .....|..|.||
Human   485 NYLVHLQERPVK--------QTISRQALSLL-------FDTYHNEVDAFLLA-DGDFPLKADRVV 533

  Fly  1141 SS------------SAQHTGTMSKRPSCVNSDTPRF---VSVLCLRSKYAGEISGLLSVLSEKDK 1190
            .|            :.:.|..:::.|.|.:...|:.   .|||.:|......:..|.:.
Human   534 QSVKAICNALAAVETPEITSALNQLPPCPSRMQPKIQKDPSVLAVRENREKVVEALTAA------ 592

  Fly  1191 AGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHAVASSQLELFTESAMETAV 1255
                   :.|:.|......:|..:.|:..:..:     ::.::..|...|.   .||..|.....
Human   593 -------ILDLVELYCNTFNADFQTAVPGSRKH-----DLVQEACHFARSL---AFTVYATHRIP 642

  Fly  1256 ECWQWVLTARQDLEL-CFI----QEMVSAWQTT---FEKRM-GLFAWETEVTHPLAAYEGCKLVS 1311
            ..|   .|:.:|..| |.:    :|:.|..||.   |.|.: .|..|:.::..|:..
Human   643 IIW---ATSYEDFYLSCSLSHGGKELCSPLQTRRAHFSKYLFHLIVWDQQICFPVQV-------- 696

  Fly  1312 KPILIAPHLIWLQLLSEMVDTAKYCNR-DKVEMFCLLLHRCLPVL---KSSKQNRQ--------- 1363
                                     || .:..:.|..|: .||:.   .||:.|:|
Human   697 -------------------------NRLPRETLLCATLY-ALPIPPPGSSSEANKQRRVPEALGW 735

  Fly  1364 VSTVGCRFK-LLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMI 1427
            |:|....|: :|.||..||.                         ..|.|..|.|..
Human   736 VTTPLFNFRQVLTCGRKLLG-------------------------LWPATQENPSAR-------- 767

  Fly  1428 LLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNP--ETASLISGGGLVNDYTRSMSA 1490
                |......:...|..:: |:..:...:..|.....:.:|  |..||
Human   768 ----WSAPNFHQPDSVILQI-DFPTSAFDIKFTSPPGDKFSPRYEFGSL---------------- 811

  Fly  1491 SGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAV 1555
                                             |....::|        ||.|:|.:|.
Human   812 ---------------------------------REEDQRKL--------KDIMQKESLY------ 829

  Fly  1556 ELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEI 1620
                                       |.....|..:|.   :..:|::
Human   830 ---------------------------WLTDADKKRLWE---KRYYCHS---------------- 848

  Fly  1621 IDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYIL--SWSPVTPIQALAYFSRQYPS 1683
               |||.|    |:.:...| :.::.|.        || :|:|  .|:.:....||......:|.
Human   849 ---EVSSL----PLVLASAP-SWEWACL--------PD-IYVLLKQWTHMNHQDALGLLHATFPD 896

  Fly  1684 HPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNMQT 1746
            ..: .:.||:.:.|.....:|.|:|||||||:::..  ..:|.|:...:.....|.|...|.::.
Human   897 QEV-RRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKD 960

  Fly  1747 NMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERK 1811
            .:        ||.........|..:::.......:..:.|:......:..::.::|..|.. .|:
Human   961 GL--------KDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNALAKLAQQVREAAPS-ARQ 1016

  Fly  1812 NACLAALSRIK----VQGGCYLPSNPEAMV-----LDIDY--SSGTPMQSAAKAPYLARFRVYRC 1865
            ......|..:|    :.|.|.||.:|..:|     .|..|  |:..|::
Human  1017 GILRTGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLK---------------- 1065

  Fly  1866 GITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLD 1930
                     :...|.....|:.::          |||.|||:|||||.||:|.|...|:.|.|||
Human  1066 ---------LSFQNVDPLGENIRV----------IFKCGDDLRQDMLTLQMIRIMSKIWVQEGLD 1111

  Fly  1931 LFLFPYRVVATAPGCGVIECVPNAKSRDQL-------GRQTDSGLSEYFQ-HQYGDESSKEFQAA 1987
            :.:..:|..:|..|.|::|.:|||::..::       |...|..|:::.| |..|::   |::.|
Human  1112 MRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGED---EYEKA 1173

  Fly  1988 RANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFG-FMFESSPGGNIGFE--PDMKLT 2049
            ..||:.|.|...:..|:|.|.||||.|||:...||:.||||| |:..:...|||..:  |.:..:
Human  1174 VENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFVFTS 1238

  Fly  2050 DEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLP 2099
            |...:|.||...|..|..|.:||.||:..:|.:....::|:.|||..|:|
Human  1239 DMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIP 1288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	36/178 (20%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	87/282 (31%)
PIK3C2B	NP_001364263.1	Interaction with GRB2. /evidence=ECO:0000269\|PubMed:11533253	2..298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..188
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..315
		PI3K_rbd	364..466	CDD:395642	28/122 (23%)
		C2A_PI3K_class_II	622..794	CDD:175979	44/249 (18%)
		PI3Ka_II	813..981	CDD:238441	45/253 (18%)
		PI3Kc_C2_beta	987..1340	CDD:119421	98/341 (29%)
		PX_PI3K_C2_beta	1369..1477	CDD:132823
		C2B_PI3K_class_II	1505..1627	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810