DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and Tor

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster


Alignment Length:2676 Identity:487/2676 - (18%)
Similarity:846/2676 - (31%) Gaps:986/2676 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 VQTLFRYCPQENAAGVFC-LDTRAQDAVIALGIYFLEGG---------CQHEGQ------IVPYL 81
            |:|..|...||..|..|. .|......|.|..|...:||         |  ||.      |.|||
  Fly    33 VKTELREMSQEELAQFFDEFDHHIFTMVNATDINEKKGGALAMKCLINC--EGSLTARKGISPYL 95

  Fly    82 LRLAKCLPKAVWIDD------ARSNKVERVRIPS---AEKFSFCLNT------------------ 119
            .||...|    .|:|      |..:.|:...:|:   |:.|.|.:..                  
  Fly    96 NRLRDLL----LINDVSVMEIAARSLVKLANMPTSKGADSFDFDIKKAFEVLRGERQEYRRHSAV 156

  Fly   120 -LLSDIAAKCPD-------SREEIILNQV------------ETLSALANIVKSSRDS---SSAPP 161
             :|.::|...|.       :..|:|.|.:            |.|.| |.||.:.|:|   ||.|.
  Fly   157 FILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALRA-ALIVTAQRESTKQSSEPQ 220

  Fly   162 PIILCKATVPLLFGLARSMGRYASNDPPLLCRIFPPELLPIQKGGGRDGTGSSS---------SA 217
            ...:|.......|.  ..:|  :|.|               |||..||......         .|
  Fly   221 WYRICYDEANGSFN--ADLG--SSKD---------------QKGVTRDDRIHGGLVVFNELFRCA 266

  Fly   218 SGTCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGRQRCAGGKPSKPSLHSYFSVPY 282
            :.|....::|.:.|.........:..|.|.|:....|                  :|.....||:
  Fly   267 NATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQLN------------------TLVPRLKVPF 313

  Fly   283 -----DPRTHF--------FTRYGSSFNQFPNM---------------RVCESPTKGGP---RPL 316
                 ..:||.        ..::.|..|...:.               .|.|..|...|   :.|
  Fly   314 IDKLGSTQTHLGEGEHHKGVAKFASQHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQAL 378

  Fly   317 YRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVTLLRE 381
            .::.|......:.:| |.|.|.|  .:.||         :..::|   |....|:..:.:..:..
  Fly   379 LQILPRLAAFNRAVF-VEKYLQT--CVSHL---------MQILRG---KEKDRTVAYITIGYMAV 428

  Fly   382 LLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNV-MANAAC 445
            .:|..:::          .:..:..:.:..|.:|.              :.:|.||.| .|..||
  Fly   429 AVQSAIEV----------HLSSIMTSVKVALPSKD--------------LTSKRKVPVDPAVFAC 469

  Fly   446 VDLLVWAIRDETVD------------------------VDYNVPSLQNGLQFLLKKEADKLCGRL 486
            :.||..|::.|..|                        :..|||.|::.:       .:.|.|.|
  Fly   470 ITLLAHAVKSEIADDVKDILEQMFYTGLSPALTVCLRELSENVPQLKSAI-------TEGLIGIL 527

  Fly   487 SQKLNLELSHKIVMDHMPLLMVCLEG-----------------LGKLAHKFPNIAGTSISYLRDF 534
            ||.|   ::...::.:..|..:.::|                 ||....:..|:. ..:....|:
  Fly   528 SQVL---MNKAAILPYTALPTIAIDGSLMQNGDGATTVLALKTLGTFNFEEQNML-DFVQRCADY 588

  Fly   535 LVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAVQHSDS----------------RTAVVIYGD 583
            .:.          |..|.:..:..:......|:|||.|:|                |..:|...|
  Fly   589 FIV----------HEQQEIRLEAVQTCTRLLKLAVQSSESMENSKTLSDTVSHVIERLLMVAITD 643

  Fly   584 -------------NQKPPGS-GTGRSGHAAFESLRDAAIENLSIAL------------------- 615
                         ::...|. ....|.::.|.:|.|...|...:|:                   
  Fly   644 MDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLR 708

  Fly   616 --------------------RAAHTLDQFCV--PALVANVSNRLF-------------------- 638
                                ::|..||...:  |.|:::..|.:.                    
  Fly   709 TTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPESNPGVILNV 773

  Fly   639 ------TAEKSGSESQGECHKSNLVSLNIIVMLGH--------VAV-ALKDTSKTTQNILQFFIQ 688
                  .||.:|...:.|....:|:|: ::.|||.        ||: .|......|..::     
  Fly   774 LRTIGDLAEVNGGSDEMELWADDLLSI-LLEMLGDAGSPDKRGVALWTLGQLISATGRVV----- 832

  Fly   689 RFCKVPSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRK-------- 745
                .|..:..:::|    ::|:..:|    |..:...|.|::...|....||...|        
  Fly   833 ----TPYHKYPVLID----ILINFLKT----EQRRSIRRETIRVLGLLGAMDPYKHKMNKGLIDS 885

  Fly   746 QFHHV----SDAVVNALGNIAANIQGDAEMLELLGKLLELF---------VQIGLDGERSYDNTP 797
            |..:|    ||..|:...:|:.     ||:|..:|..|:.:         ::|..|...|..:|.
  Fly   886 QKDNVLIAYSDGKVDESQDIST-----AELLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTS 945

  Fly   798 GAQKASSRAGNLGM-LIPVIA-VLVRRLPPIK----NPRQ-------------RLH--------- 834
            ..|..:....:||: .:|.:| ||...|..::    |.|:             :||         
  Fly   946 VVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNNLREFLFQQLAILVAFVKLHIISYMGDIF 1010

  Fly   835 KLFKDFWAYCVVMGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVNE 899
            ||.|:||.....:..|...|        ::|||         .|...:.|          |.:.|
  Fly  1011 KLIKEFWTINTPLQNTLINL--------IEQIA---------VALGCEFR----------DYLAE 1048

  Fly   900 LRSQILVLLEH--SSDNVAT-----AINKLSFAQCTYLLSVYWLEMLR---VENADEP------- 947
            |..|||.:|:|  |.|.:.|     |:.|....      ..|:|.::.   |:..|.|       
  Fly  1049 LIPQILRVLQHDNSKDRMVTRRLLQALQKFGST------LGYYLPLILPPIVKLFDSPYVPQQVS 1107

  Fly   948 --SLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVLESQATL------ 1004
              :||.|.:..|    |.|.|..       :.::......||.|..|:|::.:.:..:|      
  Fly  1108 MVALETINNLAC----QLDFTDF-------SSRIIHPLVRVLDAEPELRDQAMTTLRSLAKQLGK 1161

  Fly  1005 -LLVYFNHIH--------------------KPIQMVADQYLS---------------FLVDRFPH 1033
             .||:...:.                    |....:||.|.:               |:.||..:
  Fly  1162 KYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFKNNEPFVTDRNSN 1226

  Fly  1034 ------------LLW--NRRVL---WCMLDILQLLAYSLSLD-PNEETPTLRVVSTPYTLQLMDS 1080
                        ..|  .|||.   |  ::.|:.|:..|..: |:......|.::..|...|.|.
  Fly  1227 NKNLQVTTNELRTAWQVTRRVSKDDW--VEWLKRLSIGLLKESPSHALRACRSLAQEYDTLLRDL 1289

  Fly  1081 LPA----------------------RELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPT 1123
            ..|                      :.|::.|..:..|.|:|.|      ....|....|..|.|
  Fly  1290 FNAAFISCWTELSPDLKNELTQSLIQALQVTDMPEITQTILNLA------EFMEHCDRDPIPIET 1348

  Fly  1124 PVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEK 1188
            .:|...:....|:...:        ...:....:..|:..|.|::.:.:|           |.::
  Fly  1349 KLLGTRAMACRAYAKAL--------RYKEEEFLLREDSQVFESLILINNK-----------LQQR 1394

  Fly  1189 DKA-GLADRLVSDV---------------WEACAE---------KSDARHRGALWRATAYLIICS 1228
            :.| ||..|..:..               |:...|         .||...|....|....|...|
  Fly  1395 EAAEGLLTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWS 1459

  Fly  1229 EISRKLLHAVASSQLELFTESAMETAVECW---QWVLTARQDLELC---------FIQEMVSAWQ 1281
            |:|....|...:...|..:.:....||..|   .|  .|.::...|         :.:.:::...
  Fly  1460 ELSNVTKHEWENFGTEAKSRAGPLAAVAAWGLQDW--EAMREYVRCIPEDTQDGSYYRAVLAVHH 1522

  Fly  1282 TTFEKRMGLF-----AWETEVTHPLA-AYE---GCKLVSKPILIAPHLIWLQLLSEMVDTAKYCN 1337
            ..||....|.     ..:||:|.... :||   |.            ::.:|:|:|:.:..:|  
  Fly  1523 DDFETAQRLIDETRDLLDTELTSMAGESYERAYGA------------MVCVQMLAELEEVIQY-- 1573

  Fly  1338 RDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSN 1402
                        :.:|     ::...:.|:.  :|.||.|..|::.       .|.|:  :::|.
  Fly  1574 ------------KLIP-----ERREPLKTMW--WKRLQGGQRLVED-------WRRII--QVHSL 1610

  Fly  1403 ALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMR-SEKKHLVTSEVGDYDLTNASVSSTQMLAVR 1466
            .:.        |:       |||...||:....| |...||....:.....|:..::..|.|.. 
  Fly  1611 VVK--------PH-------EDIHTWLKYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPC- 1659

  Fly  1467 NNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKR------- 1524
            |.|:         :...||:.|:|:...             ...|..:.|..||.|:.       
  Fly  1660 NQPQ---------VTYAYTKYMAANNQL-------------QEAYEQLTHFVSTYSQELSCLPPE 1702

  Fly  1525 --SNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPDLIVPGE--------EQ 1579
              ..:.:||.      .:.|::               :.||  .|.|.|.|.|..        |:
  Fly  1703 ALKQQDQRLM------ARCYLR---------------MATW--QNKLQDSIRPDAIQGALECFEK 1744

  Fly  1580 ITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALK 1644
            .|.:....||:  |.     .|.|            .|.:::..:.|.|....|      |.|..
  Fly  1745 ATSYDPNWYKA--WH-----LWAY------------MNFKVVQAQKSALDKQQP------PGASM 1784

  Fly  1645 YLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSR---------------------QYPSHPLTA 1688
            .:.....|   ..||:.|..::    :.|:..|.|                     .|.:|....
  Fly  1785 GMTMGSGL---DSDLMIIQRYA----VPAVQGFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVY 1842

  Fly  1689 QYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNISRRSQIVAHQLIWNMQTN-----M 1748
            :..:..:......:.|..||||:  .|.||...:|         .|:: |||:.::..|     :
  Fly  1843 EALLSGMKLIEINTWLQVIPQLI--ARIDTHRQLV---------GQLI-HQLLMDIGKNHPQALV 1895

  Fly  1749 Y--------------------MDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFD---- 1789
            |                    :|..::| .|.|.|.....|:.:|.    .|..::|:..:    
  Fly  1896 YPLTVASKSASLARRNAAFKILDSMRKH-SPTLVEQAVMCSEELIR----VAILWHEQWHEGLEE 1955

  Fly  1790 ----FFG--KITAVSGEIRSFAKGIERKNACLAALSRIKVQG----GCYLPS---NPEAMVLDID 1841
                :||  .:..:...:......:||....|...|..:..|    ..|..|   ...|:|:|:|
  Fly  1956 ASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLD 2020

  Fly  1842 ------------YSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVE 1894
                        .|...|..::.:.||::. ::..|...||   |:..|.|| .||..::::...
  Fly  2021 RAWDIYYHVFQKISRQLPQLTSLELPYVSP-KLMTCKDLEL---AVPGSYNP-GQELIRISIIKT 2080

  Fly  1895 SWQAA---------------------IFKVGDDVRQDMLALQVITIFKNI-------FQQVGLDL 1931
            :.|..                     :.|..:|:|||...:|:.::...:       |::   :|
  Fly  2081 NLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRR---NL 2142

  Fly  1932 FLFPYRVVATAPGCGVIECVPNA------------KSRDQLGRQTDSGLS--------------E 1970
            .:..|.|:..:...|:|..||:.            |.:..|.::..:.|:              |
  Fly  2143 AIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVE 2207

  Fly  1971 YFQHQYG--------------DESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDK-D 2020
            .|:|..|              ..||:.:...|.|:.:|:|..|::||:|.:.|||..|:|:|: .
  Fly  2208 VFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMS 2272

  Fly  2021 GHIIHIDFGFMFESS------PGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAV 2079
            |.|:|||||..||.:      | ..|.|    :||..::..|........::..||   ...|.:
  Fly  2273 GKILHIDFGDCFEVAMTREKFP-EKIPF----RLTRMLIKAMEVTGIEGTYRRTCE---SVMLVL 2329

  Fly  2080 RPYQDAIVSLV 2090
            |..:|::::::
  Fly  2330 RRNKDSLMAVL 2340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 39/220 (18%)
PI4Kc_III_alpha 1836..2153 CDD:270711 74/342 (22%)
TorNP_001260427.1 TEL1 308..2471 CDD:227365 420/2357 (18%)
HEAT repeat 632..658 CDD:293787 3/25 (12%)
HEAT repeat 668..698 CDD:293787 6/29 (21%)
HEAT repeat 706..736 CDD:293787 2/29 (7%)
HEAT repeat 749..780 CDD:293787 1/30 (3%)
HEAT repeat 798..823 CDD:293787 7/25 (28%)
DUF3385 831..999 CDD:288698 36/189 (19%)
HEAT repeat 841..870 CDD:293787 7/36 (19%)
HEAT repeat 880..917 CDD:293787 10/41 (24%)
HEAT repeat 925..954 CDD:293787 5/28 (18%)
Rapamycin_bind 1937..2034 CDD:285924 16/100 (16%)
PIKKc_TOR 2075..2353 CDD:270713 58/277 (21%)
FATC 2440..2471 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.900

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