Protein Alignment Pi4KIIIalpha and fwd

DIOPT Version :10

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Alignment Length: 926
• Identity: 219/926 - (23%)
• Similarity: 368/926 - (39%)
• Gaps: 258/926 - (27%)

  Fly  1303 AYEGCKLVSKP----ILIAPHLI--WLQL--LSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSK 1359
            ::.|.|:.|.|    .|..|.|:  ::|:  |:|::|                     |.|
  Fly   930 SFIGNKIFSFPDQEVDLYIPQLVVMYIQMDELAEVLD---------------------PYL---- 969

  Fly  1360 QNRQVSTVGCRFKL---LQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQL 1421
                  |:.||..:   |:| |.||:.                |:..:|..........:|:..|
  Fly   970 ------TIRCRKSVDFSLKC-LWLLEA----------------YNYQVDSLGNSHNSSRKSKLAL 1011

  Fly  1422 LEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASV------------------------SSTQM 1462
            :::|.          |:::|..|..    ||.:|..                        .:|.:
  Fly  1012 MKEIF----------SKREHKQTQN----DLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVL 1062

  Fly  1463 LAVRNNPETASLISGGGLVNDY-TRSMSASGNAVGMGMGVAGGGSSSG--WYNTIPHSTS-TLSK 1523
            ||...:|.|.|:.........| |:::..:...:.:|...:|....:|  .:.|:....: .|.:
  Fly  1063 LADFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQ 1127

  Fly  1524 RSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPY 1588
            |:..|  ....|.|..|::||      .|:.|                     .:.:|.|.::..
  Fly  1128 RTLCS--CGAPKTSPQKEFMK------ALMNV---------------------GKNLTSWPSKAE 1163

  Fly  1589 KSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLL 1653
            |::..|....|.....|| .|:||               |....|..|..|.|....:..:|:
  Fly  1164 KTSALRMSLNLINKNLPA-RVWLP---------------LYSDIPHHVVRITEEKTAVLNSKD-- 1210

  Fly  1654 QESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDT 1718
             ::|.::|:    .|..|..:      |.|                     |.||:::.:|||..
  Fly  1211 -KTPYIIYV----EVVEIPDI------YTS---------------------PLIPKMMPSLRHTK 1243

  Fly  1719 M-----GYVVEFIKNI--SRRSQIVAHQLIWNMQTNMYMDED-------QQHKDPNLY------- 1762
            .     |..:...:::  ||.|...:.|...:.:.....|.|       ..:...|::
  Fly  1244 SEEHLDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQF 1308

  Fly  1763 ---EALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIRS------FAKGIERKNACLAAL 1818
               :...|....|.|.:....|   ..|.|...:|:..|.:.|.      |..|..|...|
  Fly  1309 QEDDVWSQEEDEITAQYLNMRK---VSERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHC---- 1366

  Fly  1819 SRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNS 1883
            |.:..:......::||           .|..:|.|.|:..:.::.|             .::|..
  Fly  1367 SNLSCENTKSFSNDPE-----------DPSAAALKEPWHEKEKLIR-------------ESSPYG 1407

  Fly  1884 QEDAKMTLGVESWQ--AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCG 1946
            .        :.:|:  :||.|.|||:||:::|.|::.:||.|:|:..:||::.||::|..:...|
  Fly  1408 H--------LSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSG 1464

  Fly  1947 VIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRH 2011
            :||.:.|..|..|:.:.::..|.|||..:||..|.:.|:.|:.|||:|.|||.||.||||:||||
  Fly  1465 LIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRH 1529

  Fly  2012 NGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPD-MKLTDEMVMIMGGKMDSPAFKWFCELCVQA 2075
            ||||:...|||||||||||:...|| .|:|||.. .|||.|.|.:||| ..|..::.|.:|.:..
  Fly  1530 NGNILFHSDGHIIHIDFGFILSISP-KNLGFEQSPFKLTPEFVEVMGG-TSSEHWREFNKLLLVG 1592

  Fly  2076 FLAVRPYQDAIVSLVSLMLDTG-LPCFR---GQTINLLKQRFVATKNNKEAAAHMLAVIRNSYQN 2136
            .::.|.:.|.|::.|.:|.... ||||:   ..|:..|::||......:|....:..::::|.::
  Fly  1593 MMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKS 1657

  Fly  2137 FRTRTYDMIQYYQNQI 2152
            ..|:.||..|||.|.|
  Fly  1658 LSTKLYDGYQYYTNGI 1673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	54/306 (18%)
		PI4Ka	1600..1775	CDD:238443	33/198 (17%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	113/324 (35%)
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	112/312 (36%)