Protein Alignment Pi4KIIIalpha and Pi3K92E

DIOPT Version :10

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 1019
• Identity: 212/1019 - (20%)
• Similarity: 377/1019 - (36%)
• Gaps: 292/1019 - (28%)

  Fly  1285 EKRMGLFAWETEV--THPLAAYEGCKLVSKPILIA---PHLIWLQLLSEMVD------------- 1331
            |.....:.|:..:  .|||......|:   |.||.   |...:|.::....|
  Fly   178 ELERSAYTWQQRLLYEHPLRLANSTKM---PELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDT 239

  Fly  1332 -------TAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKS 1389
                   |.:..||.:::|             :.:.:..:..|..|.:.|.....|:|...|.:.
  Fly   240 PFSLTESTLQKMNRSQMKM-------------NDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEM 291

  Fly  1390 LS----RNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGD- 1449
            ||    .|::.:.:|  .|:.:.      |...||    .|:..:.....|:...|...|.:.|
  Fly   292 LSDSAVPNVVLQSVY--RLESYI------NHHNEQ----AMVTKRPLPKKRTVHLHKSISSLWDM 344

  Fly  1450 ---YDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGG------- 1504
               :.||..|:|:...                    |.||::.     ||:.:.:..|
  Fly   345 GNYFQLTLHSISNVNF--------------------DKTRALK-----VGVHVCLYHGDKKLCAQ 384

  Fly  1505 ---GSSSGWYNT----------------IPHST-----------STLSKRSNRSKRLQYQKDSYD 1539
               .|.:|.::|                :|..|           .:.||:|:.:|.:..:...|:
  Fly   385 RSTDSPNGNFDTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKSSNNKDIALKDVPYN 449

  Fly  1540 KDYMKKRNLIL----ELLAVELEFLITW-----------------YNPN------SLPDLI---- 1573
            |:.:...|..:    ::|......|.||                 ..||      :|.||.
  Fly   450 KNPLAWVNTTIFDHKDILRTGRHTLYTWTYADDIQSVEVFHPLGTIEPNPRKEECALVDLTFLSS 514

  Fly  1574 ------VPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSD 1632
                  .|.||.:.::  ...:..|.|...:||....|...  |.:.:.|...:| ::..:|..|
  Fly   515 GTGTVRYPSEEVVLQY--AADREQVNRLQRQLAGPEKPIKE--LKELMANYTGLD-KIYEMVDQD 574

  Fly  1633 PIAVC--------HIPEALKYL--CTTKNLLQESPDLVYILSWSPVTPIQ-ALAYFSRQYPSHPL 1686
            ..|:.        .:||.|..|  |.......:..|:.|:|...|:..|: :|......||. |.
  Fly   575 RNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQWPLISIERSLELLDYAYPD-PA 638

  Fly  1687 TAQYAVKTLSSYPAESVLPYIPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNMQTNM- 1748
            ..::|::.|.....|.:|.|:.|||||::|::.  ..:|.|:...:.|:|.:.|...|::::.|
  Fly   639 VRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVVFLLERALRNQRIGHYFFWHLRSEMQ 703

  Fly  1749 --------------YMDEDQQHKDP--NLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAV 1797
                          |:...:.|..|  .....|::|.|..:.:..|:.::              |
  Fly   704 TPSMQTRFGLLLEVYLKGCKHHVAPLRKQLHVLEKLKQGSLIAKKGSKEK--------------V 754

  Fly  1798 SGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRV 1862
            ...::.|.:. :|.:|....:..         |.||.
  Fly   755 KTMLQDFLRD-QRNSAVFQNIQN---------PLNPS---------------------------- 781

  Fly  1863 YRC-GITELETRAMEVSNNP------NSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIF 1920
            :|| |:|....:.|:....|      |:..:|       |....|||.|||:|||||.||::.:.
  Fly   782 FRCSGVTPDRCKVMDSKMRPLWVVFENADVNA-------SDVHIIFKNGDDLRQDMLTLQMLRVM 839

  Fly  1921 KNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSG-------------LSEYF 1972
            ..::::.|:|..:..|..::.....|:||.|.:|::...:  |.:.|             ||...
  Fly   840 DQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANI--QKEKGMFSATSPFKKGSLLSWLK 902

  Fly  1973 QHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFM---FES 2034
            :|   ::.:.:...|...|..|.|.|.:..|:|.:.|||:.|||:.::|.:.|||||.:   |:.
  Fly   903 EH---NKPADKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKE 964

  Fly  2035 SPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFC---ELCVQAFLAVRPYQDAIVSLVSLMLDT 2096
            ..|......| ..||.:.|.::....:....|.||   |||.:|||.:|.:...|:||.|:|:.|
  Fly   965 KLGVRRERVP-FVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMIST 1028

  Fly  2097 GLPCFRGQ-TINLLKQRFVATKNNKEAAAHMLA----VIRNSYQ 2135
            |||....: .::.|::..|.....::|..|..|    .:.||::
  Fly  1029 GLPELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWK 1072

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	64/382 (17%)
		PI4Ka	1600..1775	CDD:238443	46/204 (23%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	86/331 (26%)
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589
		PI3K_rbd	200..307	CDD:197540	21/124 (17%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	33/202 (16%)
		PI3Ka_I	552..723	CDD:238444	39/174 (22%)
		PI3Kc_I	727..1084	CDD:270709	98/411 (24%)