Protein Alignment Pi4KIIIalpha and pik3cd

DIOPT Version :9

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_957493.1
• Gene: pik3cd / 394174
• ZFINID: ZDB-GENE-040426-1128
• Length: 1039
• Species: Danio rerio
• Alignment Length: 582
• Identity: 141/582 - (24%)
• Similarity: 247/582 - (42%)
• Gaps: 108/582 - (18%)

  Fly  1613 QRIKNAEIIDEEVSRLVCSD---PI------AVCHIPEAL-KYLCTTK-NLLQESPDLVYIL-SW 1665
            |::|  ||:|.:.|.....|   |:      .....||:| |.|..|| |..::...:|.:| .|
Zfish   509 QKLK--EIVDNKNSTEFFEDEKEPLWKLREELRLKYPESLPKLLLITKWNKHEDVAQMVGLLQKW 571

  Fly  1666 SPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGY----VVEFI 1726
            ..:..:.||......:|. |....:.::.|...|.:.:..|:.||||.|::::  |    :..|:
Zfish   572 PELPALHALELLDYSFPD-PHVRFFTIRCLRKLPDDKLFQYLLQLVQVLKYES--YLDCDLTSFL 633

  Fly  1727 KNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPN-------LYEALDQLSQSIIASFSGAAKRFY 1784
            ...:..::.:.|.|.|::::.|::        |:       :.||..:.|...|.|..
Zfish   634 LERALANKKIGHFLFWHLRSEMHV--------PSVSLRFGLILEAYCRGSIFHIKSLM------- 683

  Fly  1785 EREFDFFGKITAVSGEIRSFAKGIER------KNACLAALSRIKVQGGCYLPSNPEAMVLDIDYS 1843
             ::.:...|:.|::..::|.::...|      ...|:...:.::.......|.:|..::.::...
Zfish   684 -KQNEALNKMKALNDFVKSASQKATRIQTTEDMKVCIKQETYMEALSDVVSPLSPSIILCELCAD 747

  Fly  1844 SGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVR 1908
            ....|.|..|..:|    :|:                  |:.|   ::|:      |||.|||:|
Zfish   748 KCKFMDSKMKPLWL----MYK------------------SKYD---SVGI------IFKNGDDLR 781

  Fly  1909 QDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLGRQT--------- 1964
            ||||.||:|.|...:::..||||.:.||..::|....|:||.|.|:.:...:.|..
Zfish   782 QDMLTLQMIQIMDILWKTEGLDLRMQPYGCLSTGNKTGLIEVVKNSDTIANIQRNNSNSAATAAF 846

  Fly  1965 --DSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHID 2027
              |:.|:.......||:..:..:    .|..|.|.|.:..|:|.|.|||:.||||.:.|.:.|||
Zfish   847 NKDALLNWLKSKNPGDKLDQAIE----EFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHID 907

  Fly  2028 FGFM---FESSPGGNIGFEPDMKLTDEMVMIMGGKM-DSPAFKWFCELCVQAFLAVRPYQDAIVS 2088
            ||..   |:|..|.|....|.:...|.:.:|..|:. :|..|:.|...|.||:..:.......|:
Zfish   908 FGHFLGNFKSKFGINRERVPFILTYDFVHVIQEGRTNNSEKFERFRVCCEQAYKILCRNGTLFVN 972

  Fly  2089 LVSLMLDTGLPCFR-GQTINLLKQRFVATKNNKEAAAHMLA----VIRNSYQ---NFRTRTY 2142
            |.:||...|||... .:.|..||......|:.:||..:...    .:|.|::   |:...|:
Zfish   973 LFALMKAAGLPELNSSKDIQYLKDSLALGKSEEEALKNFKVKFNEALRESWKTKVNWMMHTF 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	42/184 (23%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	91/330 (28%)
pik3cd	NP_957493.1	PI3K_p85B	32..107	CDD:280372
		PI3K_rbd	188..280	CDD:295323
		C2_PI3K_class_I_beta_delta	315..481	CDD:176075
		PI3Ka_I	505..676	CDD:238444	40/179 (22%)
		PI3Kc_IA_delta	676..1038	CDD:270718	100/402 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810