Protein Alignment Pi4KIIIalpha and Pi3K59F

DIOPT Version :10

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_477133.1
• Gene: Pi3K59F / 37733
• FlyBaseID: FBgn0015277
• Length: 949
• Species: Drosophila melanogaster
• Alignment Length: 889
• Identity: 199/889 - (22%)
• Similarity: 319/889 - (35%)
• Gaps: 292/889 - (32%)

  Fly  1469 PETASLI------SGGG---LVNDYTRSMSASGNAVGMGM-------GVAGGGSSSGWYNTIPHS 1517
            |.:|.|:      ||.|   ::...:.||.........||       ||.|.|:       .|..
  Fly   102 PRSAMLVLTILDCSGAGQTTVIGGTSISMFGKDGMFRQGMYDLRVWLGVEGDGN-------FPSR 159

  Fly  1518 TSTLSKRSNRS--KRL----------QYQK-DSYDK-----------------DYMKKRNLILEL 1552
            |....|.|::|  :||          |.|| |..|:                 |||   .|::|.
  Fly   160 TPGKGKESSKSQMQRLGKLAKKHRNGQVQKVDWLDRLTFREIEVINEREKRMSDYM---FLMIEF 221

  Fly  1553 LAVELE----FLITWYNPN--------SLPDLI-VPGEEQITEWRNRPYKSTVWRDYARLAWC-- 1602
            .|:.::    :.:.::.|.        :.|.|: ||..|...|       :.|.|.:.|||..
  Fly   222 PAIVVDDMYNYAVVYFEPEGDVKYKLPAKPKLVSVPDSEIQME-------NLVERKHHRLARSER 279

  Fly  1603 -------YNPALAV-----FLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPEAL-KYL-CTTKNLL 1653
                   ..|..::     .:..|.....::..|...||......:....:|| |:| |....|.
  Fly   280 SGISDRDAKPTASIRDQLHTIVYRYPPTYVLSSEEQDLVWKFRFYLSSHKKALTKFLKCINWKLE 344

  Fly  1654 QESPDLVYIL-SWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHD 1717
            .|....:::| :|:|:....||...|..: :||...:|||..|:..|.|.:|.|:.||||||:::
  Fly   345 DEVTQALWMLANWAPMDVEDALELLSPTF-THPQVRKYAVSRLAQAPDEDLLLYLLQLVQALKYE 408

  Fly  1718 TMGYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKR 1782
            ...::|.....|.....:|...|                 |.| ...|||.|.|.:::.|
  Fly   409 DPRHIVHLHGCIFPERDVVRSIL-----------------DDN-GSLLDQSSLSDLSATS----- 450

  Fly  1783 FYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIKV-------------QGGCYLPSNPE 1834
                           ||...|.....:|..:.|||:...|.             ||...|| ||.
  Fly   451 ---------------SGLHGSVIPANQRAASVLAAIKSDKSVSPGSAGGSGSGGQGSVALP-NPS 499

  Fly  1835 AMVLDIDYSSGTPMQSAAKAPYLAR-------------FRVYRC----------------GITEL 1870
            |..  ...||..|..|.:.|..||.             |.:.|.                .:.|:
  Fly   500 APA--TPGSSSLPCDSNSNALMLAEGISFGSVPANLCTFLIQRACTNATLANYFYWYLSIEVEEV 562

  Fly  1871 ET------RA-----------MEVSNNPN---------------------------SQEDAKMTL 1891
            |:      ||           ::|..|.|                           ::|......
  Fly   563 ESVRKQDERAHDMYAMVLKMFLKVLENGNFNLRGIFYNLRKQRRFIDELVKLVKLVAKEPGNRNK 627

  Fly  1892 GVESWQ----------------------------------------------------------- 1897
            ..|.:|
  Fly   628 KTEKFQKLLAEQDMFKVNFTNFEPIPFPLDPEIYITKIVPMRTSLFKSALMPAKLTFVTSIAHHE 692

  Fly  1898 -AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQLG 1961
             |||||.|||:|||.|.||:||:...:.::..|||.|.||:|:||:...|.::.|.:....:.|.
  Fly   693 YAAIFKHGDDLRQDQLILQMITLMDKLLRRENLDLKLTPYKVLATSSKHGFLQYVDSCTVAEVLA 757

  Fly  1962 RQTDSGLSEYFQHQYGDESSKEFQAARA--NFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHII 2024
            |  :..:..:|:..:..::.....:|..  .::||.|.|.:|.|||.:.|||..|:::..:|.:.
  Fly   758 R--EGNIHNFFRKHHPCDNGPYGISAEVMDTYIKSCAGYCVITYLLGVGDRHLDNLLLTTNGKLF 820

  Fly  2025 HIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSL 2089
            |||||::....|.   ...|.|||:.|||..||| :.|.....|.:.|..|:|.:|.:.:.:::|
  Fly   821 HIDFGYILGRDPK---PMPPPMKLSKEMVEAMGG-ISSEHHHEFRKQCYTAYLHLRRHANVMLNL 881

  Fly  2090 VSLMLDTGLPCFR---GQTINLLKQRFVATKNNKEAAAHMLAVI 2130
            .|||:|..:|...   .:.:..:::.......::||..|:.:::
  Fly   882 FSLMVDATVPDIALEPDKAVKKVEENLQLGLTDEEAVQHLQSLL 925

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	33/159 (21%)
		PI4Ka	1600..1775	CDD:238443	46/191 (24%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	94/433 (22%)
Pi3K59F	NP_477133.1	C2_PI3K_class_III	27..186	CDD:176042	21/90 (23%)
		PI3Ka_III	284..561	CDD:238442	70/318 (22%)
		PI3Kc_III	601..945	CDD:270628	78/331 (24%)