DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and Pik3cd

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	XP_038966422.1	Gene:	Pik3cd / 366508	RGDID:	1310990	Length:	1048	Species:	Rattus norvegicus

Alignment Length:	1275	Identity:	242/1275 - (18%)
Similarity:	424/1275 - (33%)	Gaps:	435/1275 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  1023 YLSFLVDRFPHLLWNRRVLW---------------------CM---------------------- 1044
            ||:|.|.|..:|...::|||                     |:
  Rat    31 YLNFPVSRNANLSTIKQVLWHRAQYEPFFHMLSDPEAYVFTCVNQTAEQQELEDEQRRLCDIQPF 95

  Fly  1045 LDILQLLAYSLSLDPNEETPTLRVVSTPYTLQL------MDSLPARELRLKDFADRCQGIVNEA- 1102
            |.:|:|:|       .|.....:::::..:|.:      .|||  |:..:.||..:.:....||
  Rat    96 LPVLRLVA-------REGDRVKKLINSQISLLIGKGLHEFDSL--RDPEVNDFRTKMRQFCEEAA 151

  Fly  1103 --------MKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNS 1159
                    ::|...|       :|.|:........:||.            |   :|.||..||
  Rat   152 AHRQQLGWVEWLQYS-------FPLQLEPSARGWRAGLL------------H---VSNRPLLVN- 193

  Fly  1160 DTPRFVSVLCLRSKYAGEISGLLSVLSEKD------------KAGLADRLVSDVWEACAEKSDAR 1212
                        .|:.|........:|.||            ||.:..:.:.:..|..|.:.:.|
  Rat   194 ------------VKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVERPEEYALQVNGR 246

  Fly  1213 HR---GALWRATAYLIICSEISRKLLHAVASSQLELFTESAM----------------------- 1251
            |.   |: :....:..|||     .||:..:..|.:...|::
  Rat   247 HEYLYGS-YPLCHFQYICS-----CLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPRVKPPP 305

  Fly  1252 -----ETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRM------GLFAWETEVTHPLAAYE 1305
                 .::|..|        .||..|..|::...:...::||      |||.....:
  Rat   306 IPAKKPSSVSLW--------SLEQPFCIELIEGRKVNADERMKLVVQAGLFHGNEML-------- 354

  Fly  1306 GCKLV-SKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGC 1369
             ||.| |..:.:....:|.|.|...:   ..|:..::...|..|:..:...|.::..::.|
  Rat   355 -CKTVSSSEVNVCSEPVWKQRLEFDI---SICDLPRMARLCFALYAVVEKAKKARSTKKKS---- 411

  Fly  1370 RFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNAL--DYFCGPPTCPNQSREQLLEDIMILLKFW 1432
              |...|.::                    ::|.:  ||           ::||......|. .|
  Rat   412 --KKADCPIA--------------------WANLMLFDY-----------KDQLKTGERCLY-MW 442

  Fly  1433 QTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGM 1497
            .::..||..|: :..|               .||.||.|.   |...|| .|...::
  Rat   443 PSVPDEKGELM-NPAG---------------TVRGNPNTE---SAAALV-IYLPEVA-------- 479

  Fly  1498 GMGVAGGGSSSGWYNTIPHST--STLSK-----RSNRSKRLQYQKDSYDKDYMKKRNLILELLAV 1555
                             ||..  ..|.|     |.....|:..::....::.:::|
  Rat   480 -----------------PHPVYFPALEKILELGRHGERGRITEEEQLQLREILERR--------- 518

  Fly  1556 ELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEI 1620
                                |..::.|..    |..||:
  Rat   519 --------------------GSGELYEHE----KDLVWK-------------------------- 533

  Fly  1621 IDEEVSRLVCSDPIAVCHIPEAL-KYLCTTK-----NLLQESPDLVYILSWSPVTPIQALAYFSR 1679
            :..||..          |.|||| :.|..||     ::.|.|..|..:.||..:..:.||.....
  Rat   534 MRHEVQE----------HFPEALARLLLVTKWNKHEDVAQLSQMLYLLCSWPELPVLSALELLDF 588

  Fly  1680 QYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGY----VVEFIKNISRRSQIVAHQL 1740
            .:|. .....:|:|:|.....:.:..|:.||||.|::::  |    :.:|:...:..::.:.|.|
  Rat   589 SFPD-CYVGSFAIKSLRKLTDDELFQYLLQLVQVLKYES--YLDCELTKFLLGRALANRKIGHFL 650

  Fly  1741 IWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGE----- 1800
            .|::::.|::                   .|:...| |.....|.|......|:....||
  Rat   651 FWHLRSEMHV-------------------PSVALRF-GLIMEAYCRGSTHHMKVLMKQGEALSKL 695

  Fly  1801 --IRSFAKGIERK----------NACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAK 1853
              :..|.|...:|          :.|:...:.::.......|.:|..::.::
  Rat   696 KALNDFVKASSQKTTKPQTKEMMHMCMRQETYMEALSHLQSPLDPSTLLEEV------------- 747

  Fly  1854 APYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVIT 1918
                  ..|.:|...:.:.:.:.:..:......|. ::|:      |||.|||:|||||.||:|.
  Rat   748 ------CSVEQCTFMDSKMKPLWIMYSSEKAGGAG-SVGI------IFKNGDDLRQDMLTLQMIQ 799

  Fly  1919 IFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAK--SRDQLGRQTDSGLSEYFQHQY----- 1976
            :...:::|.||||.:.||..:.|....|:||.|.::.  :..||.:...:..:.:.:...
  Rat   800 LMDFLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQLNKSNMAATAAFNKDALLNWLK 864

  Fly  1977 GDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFGFM---FESSPGG 2038
            .....:....|...|..|.|.|.:..|:|.|.|||:.||||.:.|.:.|||||..   |::..|.
  Rat   865 SKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGI 929

  Fly  2039 NIGFEPDMKLTDEMVMIMGGKM-DSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLP--- 2099
            |....|.:...|.:.:|..||. :|..|:.|...|.:|:..:|.:....:.|.:||...|||
  Rat   930 NRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRAAGLPELS 994

  Fly  2100 CFRGQTINLLKQRFVATKNNKEAAAHMLA----VIRNSYQ 2135
            |  .:.|..||......|..:||..|...    .:|.|::
  Rat   995 C--SKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESWK 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	34/184 (18%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	83/318 (26%)
Pik3cd	XP_038966422.1	PI3K_p85B	32..107	CDD:396665	14/81 (17%)
		PI3K_rbd	182..281	CDD:395642	25/132 (19%)
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	45/269 (17%)
		PI3Ka	504..687	CDD:214537	45/274 (16%)
		PI3Kc_IA_delta	679..1046	CDD:270718	92/382 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810