DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and Pik3c2a

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_001101970.1 Gene:Pik3c2a / 361632 RGDID:1310389 Length:1687 Species:Rattus norvegicus


Alignment Length:1362 Identity:259/1362 - (19%)
Similarity:482/1362 - (35%) Gaps:425/1362 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   889 TLAIKSDSVNELRSQILVLLEHSSDNVATAINKL-----------SFAQ--------------CT 928
            :|.:::..|.:.:||:.....:.:.::||..:.|           :|.|              ||
  Rat   340 SLIVRTTQVTKAQSQVSQKDPNGTSSLATGSSLLQEFEVQNEEVAAFCQSIMKLKTKFPYTDHCT 404

  Fly   929 ---YLLSVYWLE------------MLRVENADEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQ 978
               ||||...::            .:.:|...:|     :::.||             |....|.
  Rat   405 NPGYLLSPVTVQRNMCGENASVKVSIEIEGFQQP-----VTFTCD-------------VSSTVDI 451

  Fly   979 VFEKFRNVLYAHDEI--------------REKVLESQATLLLVYFNHI---HKPIQMVADQYLSF 1026
            :.  .:.:.:.||::              :|:||::         ||.   |:.||....     
  Rat   452 II--MQALCWVHDDLNQVDVGSYILKVCGQEEVLQN---------NHCLGSHEHIQNCRK----- 500

  Fly  1027 LVDRFPHLLWNRRVLWCMLDILQLLAYSLSLD------PNEETPT-----LRVVSTPYTLQLMDS 1080
                     |:..:.      ||||.:|....      .::|.|.     |..:..||. ::|..
  Rat   501 ---------WDTEIK------LQLLTFSAMCQNLARTAEDDEAPVDLNKYLYQIEKPYK-EVMTR 549

  Fly  1081 LPARELRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLAL----------- 1134
            .|..||                           |..|..|:...:...:...|:           
  Rat   550 HPVEEL---------------------------LDSYHYQVELALQTENQHRAIDQVIKAVRKIC 587

  Fly  1135 -AFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLV 1198
             |.|.|.:.:.  |..:.|....||....:...|..|......:.|...|:..|.......|.|.
  Rat   588 SALDGVETPAV--TEAVKKLKRAVNLPRNKSADVTSLSGGDTSKNSTRGSLNLENPVQVSMDHLT 650

  Fly  1199 SDVWEACAEKSDARHRGALWRATAYLIICSEISRKLLHA-VASSQLELFTESAMETAVECWQWVL 1262
            :.:::..     ..|..:...:|    :|.:.||.:..| .|:.||: ||..|......  .||.
  Rat   651 AAIYDLL-----RLHTNSCKSST----VCPQGSRNIKEAWTATEQLQ-FTVYAAHGISS--NWVS 703

  Fly  1263 TARQDLELCFI----QEMVSAWQT----TFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPH 1319
            ...:...:|.:    :::....|:    |::....|..|:..:..|:      ::...|:....|
  Rat   704 NYEKYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWDELIIFPI------QISQLPLESVLH 762

  Fly  1320 LIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFK-LLQCGLSLLQG 1383
            |....:|::...::...|:.:               |..:...:||.....|| .|.||..||  
  Rat   763 LTLFGVLNQSSGSSPDSNKQR---------------KGPEALGKVSLTLFDFKRFLTCGTKLL-- 810

  Fly  1384 NTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVG 1448
                      .|....::|::     |...|.:|  .::|.|::.:.|            .|...
  Rat   811 ----------YLWTSSHTNSI-----PGAIPQKS--YVMERIVLQVDF------------PSPAF 846

  Fly  1449 DYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAV-GMGMGVAGGGSSSGWYN 1512
            |...|:..:.       ||            ::..|  .:.|..|.: |..:.:....||.|   
  Rat   847 DIIYTSPQID-------RN------------IIQQY--KLEALENEIKGKLLDIVHRDSSFG--- 887

  Fly  1513 TIPHSTSTLSKRSNRSKRLQYQKDSYDKDYM-KKRNLILELLAVELEFLITWYNPNSLPDLIVPG 1576
                    |||.              ||.:: :||...|:             :||.||.::.  
  Rat   888 --------LSKE--------------DKAFLWEKRYYCLK-------------HPNCLPKILA-- 915

  Fly  1577 EEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCHIPE 1641
              ....|:        |.:.|:                                           
  Rat   916 --SAPNWK--------WANLAK------------------------------------------- 927

  Fly  1642 ALKYLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPY 1706
                   |.:||.:         |.|:.|:.||.....::....:.: .||..:.:...:.:...
  Rat   928 -------TYSLLHQ---------WPPLCPLAALELLDAKFADQEVRS-LAVSWIEAISDDELTDL 975

  Fly  1707 IPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLS 1769
            :||.||||:::..  ..:|.|:.:.:..:..:||.|.|.:       :|..| |.......:.:.
  Rat   976 LPQFVQALKYEIYLNSSLVRFLLSRALGNIQIAHSLYWLL-------KDALH-DTRFGSRYEHVL 1032

  Fly  1770 QSIIASFSGAAKRFYEREFDFFGKITAVSGEIRSFAKGIERKNACLAALSRIK---VQGGCYLPS 1831
            .::::......:....::......:..|:.::|. |.|..|:.....::.|::   ::..|.:|.
  Rat  1033 GALLSVGGKGLREELSKQMKLVQLLGGVAEKVRQ-ASGSARQVVLQKSMERVQSFFLRNKCRVPL 1096

  Fly  1832 NPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESW 1896
            .|..:..:::..|.:...|.|                 :..:...|:.:|..:|...|       
  Rat  1097 KPSLVAKELNIKSCSFFSSNA-----------------MPLKVTMVNADPLGEEINVM------- 1137

  Fly  1897 QAAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQL- 1960
                ||||:|:||||||||:|.|...|:.:.||||.:..::.::|....|::|.||.:.:..:: 
  Rat  1138 ----FKVGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFKCLSTGRDQGMVELVPASDTLRKIQ 1198

  Fly  1961 ------GRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDK 2019
                  |...|..|:|:.: :| :.|.:|::.|..||:.|.|...:..|:|.|.||||.|||:..
  Rat  1199 VEYGVTGSFKDKPLAEWLR-KY-NPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNIMLRS 1261

  Fly  2020 DGHIIHIDFG-FMFESSPGGNIGFEPD---MKLTDEMV-MIMGGKMDSPAFKWFCELCVQAFLAV 2079
            .||:.||||| |:..:...|:  |:.|   ..||.:|. :|.||:..:..|:.|.:||.||:..:
  Rat  1262 TGHMFHIDFGKFLGHAQMFGS--FKRDRAPFVLTSDMAYVINGGEKPTIRFQLFVDLCCQAYNLI 1324

  Fly  2080 RPYQDAIVSLVSLMLDTGLPCFRG-QTINLLKQRFVATKNNKEAAAHMLAVIRNSYQNFRTR 2140
            |...:..::|:|||:.:|||.... |.:..::........:.||......:|.:|..:..|:
  Rat  1325 RKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAEATIFFTRLIESSLGSIATK 1386

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 25/176 (14%)
PI4Kc_III_alpha 1836..2153 CDD:270711 91/318 (29%)
Pik3c2aNP_001101970.1 PI3K_rbd 411..514 CDD:279173 22/151 (15%)
C2A_PI3K_class_II 678..850 CDD:175979 40/226 (18%)
PI3Ka_II 871..1039 CDD:238441 44/285 (15%)
PI3Kc_C2_alpha 1044..1396 CDD:270720 100/376 (27%)
PX_PI3K_C2_alpha 1427..1535 CDD:132822
C2B_PI3K_class_II 1561..1682 CDD:176027
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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