DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and mei-41

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	NP_523369.2	Gene:	mei-41 / 32608	FlyBaseID:	FBgn0004367	Length:	2517	Species:	Drosophila melanogaster

Alignment Length:	2204	Identity:	396/2204 - (17%)
Similarity:	678/2204 - (30%)	Gaps:	826/2204 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 FSETL-NLVLVTLLRELLQHQVDLPTPFTKDVQEFVKRLFLNGQTELQNKQQDQERERREENGIA 430
            |.|.| ||||..:       :..|..|.|:. ....:|..||..|.:.:         .|:|.|.
  Fly   692 FLEQLANLVLAAI-------KAMLAKPLTEQ-NVLQQRSMLNVLTAIAH---------MEDNEIW 739

  Fly   431 VVNKYKVN----------------VMANAAC-------VDLLVWAIRDE---TVDVDYNVPSLQN 469
            :.:.:|:.                :.|...|       :.|..|..||.   ||.:..|| .|.:
  Fly   740 LFHWFKMTFFFLVHTRSLVAQEAVLAATEMCASQGLQTIHLWNWYKRDALDLTVRLALNV-YLLD 803

  Fly   470 GLQFLLKKEA-DKLCG-RLSQKLNLELSHKI----VMDHMPLLMVCLEGLGKLAHKFPNIAGT-- 526
            |::|.....| .|:.| ...|:...:. |::    |:.|..:..:|...|..:|.:.....||
  Fly   804 GVRFTRSLRALTKMLGFTCVQEFTCKY-HRLLTAMVLPHCIVNPLCKGVLVLIAKQMQKHIGTLF 867

  Fly   527 SISYLRDF---LVAPSPILG----KLHDHAMQSLAQQKKEKELTPFKIAVQHSDSRTAV---VIY 581
            |||:||.:   .:...|.|.    :|.....||..||            :.::|.:..|   :||
  Fly   868 SISFLRIYTHVFLTEEPELANSCIELVVSCTQSSLQQ------------LMNADVKQTVAELLIY 920

  Fly   582 GDNQKPPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNRLFTAEKSGSE 646
             .|:.|                        :..:|:..:|.|..:.:| ..:|::...||
  Fly   921 -FNRNP------------------------TFVMRSFQSLLQLSIGSL-EELSSQTANAE----- 954

  Fly   647 SQGECHKSNLVSLNIIVMLGHVAVALKDTSKTTQNILQFFIQRFCKVPSEQNALIVDQLGCMIIS 711
                  .:|.::...:.::.:....|.:.|             |.|...|:....:.|:...:.|
  Fly   955 ------FANFIAERFLGVITYFESCLSEPS-------------FEKPLKEETLYSLGQIMRFVGS 1000

  Fly   712 QCETHVFDEIMKMFSRV-TVQSASLAYTSDPEHRK---QFHHVSDAVVN------ALGNIAANIQ 766
            |..|....:|:.|.|.| |:|        :|..::   :..|:...|||      :||.|.|.:|
  Fly  1001 QHVTQFRFKIIAMLSFVHTLQ--------EPRLQRICLKIWHIFLHVVNVQELGPSLGRIVATLQ 1057

  Fly   767 ---GDAEMLELLGKLLELFVQIGLDGERSYDNTPGAQKASSRAGNLGMLIPVIAVLVRRLPPIKN 828
               .|.|.::.:..|.|..:                   ...|..||..|..:..|.|    ::|
  Fly  1058 PLLADNESVKQVNDLYEFII-------------------LRNASMLGTFITDLYFLDR----MEN 1099

  Fly   829 PRQRLHKLFKDFWAYCVVMGFTNARLWPADWYQGVQQIAAKSPLLISQTAHKSDMRELNYTLAIK 893
            ....:.|..:...|:..:              :|:.:...:||.|:.|         |.:.....
  Fly  1100 VSPSIQKCIRRHTAHLDL--------------KGLAEEENQSPPLVDQ---------LRFLQKHI 1141

  Fly   894 SDSVNELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVENADEPSLEPIMSYLCD 958
            :|...::|   :..|:|..|.......||:    :.:||         |...||.||.|::.|.
  Fly  1142 TDECLQVR---VYALQHLGDLFGRRRPKLN----STILS---------ELPLEPMLEQIVNVLM- 1189

  Fly   959 TALQRDKTGIWQC-VKCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHI---HKPIQMV 1019
            ...|.|.:.:... .||:.:         |.|.|          |:.|...:|..   |.|:.::
  Fly  1190 AGCQHDDSQLQMASAKCLGE---------LGAID----------ASYLPSNYNFASPQHLPLNIL 1235

  Fly  1020 ADQY----LSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDS 1080
            :|.:    |:.|...:......:.|....|.|.:.||. ..:.|.|:.          .:||..|
  Fly  1236 SDDFAVLALTSLCRGYQFQQNTKHVDSFSLAIQETLAI-CGISPKEQK----------KVQLWQS 1289

  Fly  1081 LPARELRLKD-FADRCQGIVNE----------------------AMKWA-------PRSTRSH-L 1114
            ||||..:|.: ....|...|:.                      |..||       |.|.|.| |
  Fly  1290 LPARMRQLMEPMLHSCYTCVHRPSTCLQQPLFGSHYSHNYYEEWAFLWASRLIDYLPSSGRRHLL 1354

  Fly  1115 QEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLCLRSKYAGEIS 1179
            ..|     .|.:...|.:...|...:...|....|..:|    |.....|::||....:.:..:.
  Fly  1355 SSY-----KPCIKRDSNMLSTFYPYILLHALLECTTEQR----NHIQEEFMAVLQANEESSSSVR 1410

  Fly  1180 GL--LSVLSE---------KDKAG---LADRLVSDVWEACAEKSDA----RHRGALWRATAYLII 1226
            |.  |..:.|         |..||   ||..||||      .|.|:    |..|.|
  Fly  1411 GRQELGAIKENAFKQFESRKYAAGIKPLASTLVSD------RKEDSSRVPRLAGKL--------- 1460

  Fly  1227 CSEISRKLLHAVASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLF 1291
            |:|:                                       |.|:|..:..||....:..|
  Fly  1461 CAEL---------------------------------------LDFLQRWLREWQRIHGRSTG-- 1484

  Fly  1292 AWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHRCLPVLK 1356
                               .||             .|.:|:    |..|:..|.
  Fly  1485 -------------------GKP-------------PETIDS----NYRKIHEFL----------- 1502

  Fly  1357 SSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSL-SRNILRERIYSNALDYFCGPPTCPNQSREQ 1420
                                       |.|||.| ||.......|:.||.|............::
  Fly  1503 ---------------------------NLIPKLLVSRASYNCGEYARALSYLESYLEEGEDKSQR 1540

  Fly  1421 LLEDIMILLKFWQTMRSEKKHLVTSEVGDYD-------LTNASV--------------SSTQMLA 1464
            |||....|::.:.::|.........:|..||       |.|..|              |||..:.
  Fly  1541 LLEQFTFLVEVYGSLRDPDSVEGAVQVRSYDMSVTQDILVNRLVERQQDMITSYEQLLSSTDQMQ 1605

  Fly  1465 -----------VRNNPETASLISGG---GLVNDYTRSMSASGNAV---GMGMGVAGGGSSSGWYN 1512
                       :|:.|:||.||:.|   .|.:.|:....|...:.   .:|.........|.|
  Fly  1606 PDHVRAMIDAYLRDTPKTAQLIADGLWQRLSDRYSDQCFAECKSELLWRLGSYDEMEELQSNW-- 1668

  Fly  1513 TIPHSTSTLSKRSNRSKRLQY---------------------QKDSYDKDY--MKKRNLILELLA 1554
            ....|...|..|...:.|:::                     |:.||...|  :.|.:|:.||
  Fly  1669 PAQCSQGCLKLRRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYANAYDAVLKLHLVHEL-- 1731

  Fly  1555 VELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQ-RIKNA 1618
                        :...:|:    |::.:.|:...:..:.::|.. .|.|.  |.:..|| ||:.:
  Fly  1732 ------------HCSQELV----EKLEQDRDEDNQEKLMKNYFD-DWQYR--LQIVQPQVRIQES 1777

  Fly  1619 ------EIIDEEVSRLVCSDPI---------------------------AVCHIPEALKYLCTTK 1650
                  .|:.|...||...:.:                           |..:|.:|.:|
  Fly  1778 IYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNSAQINRNAGQLQRAQLYILKAAEY----- 1837

  Fly  1651 NLLQESPDLVYI----LSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSS-------------- 1697
                 .|..::|    |.|.....:.|:.|...|........|..||.|::
  Fly  1838 -----QPSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQGNVKQLAAEQRHLFFRGKYLQA 1897

  Fly  1698 -YPAES-------VLPYIPQLVQALRHDTMGYV--VEFIKNI-----SRRSQIVAHQ--LIWNMQ 1745
             |.|||       ||.|..:.:...|.....:|  .:|::.|     ..:|:....|  ::.|:.
  Fly  1898 VYSAESMHLCADAVLKYFQEAIAVHRQSESCHVQMAQFLEKILEARQGGKSEPTGEQDDMLINVM 1962

  Fly  1746 TN---------------------MYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFD 1789
            .|                     :::|..:...:....:.::.|..:...:...|.  ||.....
  Fly  1963 VNYAKSLRYGSEHVYQSMPRLISLWLDTTESSTNTEQVKKMNDLLTNCCTALPTAV--FYTVYSQ 2025

  Fly  1790 FFGKITAVSGEIRSFAKGI-------------------------ERKNACLAALSRIKVQGGCYL 1829
            ...::.....::.:..:.:                         .|...|...|:..::|...:
  Fly  2026 MLSRLCHPVNDVFTVLRNVIIKLVEAYPQQSLWMLLPHFKSAKAHRIKRCKLVLTDSRLQNSTF- 2089

  Fly  1830 PSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELETRAMEVSNNP------------- 1881
                :.::.|.:..:...|....|...|.  |.|:  :::|:||..::...|
  Fly  2090 ----QKLLQDFNSLTERLMDLTNKEVTLD--RTYK--LSDLDTRLSKLCKQPEFSQILLPFEKYM 2146

  Fly  1882 ----------NSQEDAKM-------------TLGVESWQAAIF---------------------- 1901
                      ||.|.:.:             .:.:..:|.::.
  Fly  2147 QPTLPLNSDSNSSEGSHLPANQSTVNWFPYQQIYISGFQESVLILRSAAKPKKLTIRCSDGKDYD 2211

  Fly  1902 ---KVGDDVRQDMLALQVITIFKNIFQQVGLD-------LFLFPYRVVATAPGCGVIECVPNAKS 1956
               |..||:|:|...::...:.|....|   |       |.:..|.|:.....||::|.:||..|
  Fly  2212 VLVKPKDDLRRDARLMEFNGLVKRYLHQ---DAPARQRRLHIRTYAVLPFNEECGLVEWLPNLAS 2273

  Fly  1957 RDQL-------------GRQTDS--------------------------GLSEYFQHQYGDESSK 1982
            ...:             .||..|                          ...|:.:.::....|
  Fly  2274 YRSICMNLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHS- 2337

  Fly  1983 EFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMI-DKDGHIIHIDFGFMFESSPGGNIGFEPDM 2046
             :..||..:::::|..|::||:|.:.|||..||:. :.:|..:|:||..:|..   |.:...|::
  Fly  2338 -WYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQ---GELLPYPEV 2398

  Fly  2047 ---KLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINL 2108
               :||..|::.||......:|:..||:                                 |:.|
  Fly  2399 VPFRLTHNMIVAMGPLGVEGSFRKCCEI---------------------------------TLRL 2430

  Fly  2109 LKQRF-------------VATKNNKEAAAHMLAVIRNSYQNFRTRTYDMIQYYQ-NQIP 2153
            |||..             |..:..|.||.   |.|....|....|....::..| |.||
  Fly  2431 LKQESKTLMSILRPFVYDVGAQTRKGAAT---AKITKDVQRIADRLQGHVKRQQANSIP 2486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	43/264 (16%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	78/441 (18%)
mei-41	NP_523369.2	UME	955..1060	CDD:214825	26/125 (21%)
		FAT	1653..1985	CDD:280429	60/364 (16%)
		PIKKc_ATR	2181..2448	CDD:270625	55/307 (18%)
		FATC	2486..2517	CDD:280430	1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900