DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and Pik3c2b

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	XP_006249816.1	Gene:	Pik3c2b / 289021	RGDID:	1306541	Length:	1633	Species:	Rattus norvegicus

Alignment Length:	1293	Identity:	263/1293 - (20%)
Similarity:	442/1293 - (34%)	Gaps:	422/1293 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   897 VNELRSQILVLLEHSSDNVATAINKLSFAQCTYLLSVYWLEMLRVEN--ADEPSLEPIMSYLCDT 959
            |:|.|.:.:....|..|.:.|..:...::    |....|..:.....  .||.:|:  ::.|||
  Rat   327 VSEERDEEVAAFCHMLDILRTGSDTQDYS----LTGCVWSTVTPSPEHLGDEVNLK--VTVLCD- 384

  Fly   960 ALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVLESQATLLLVYFNHIHKPIQMVADQYL 1024
            :|:...|....|...|...:::   .:.|.|||:||          :...:.:.||
  Rat   385 SLREPLTFTCNCSSTVDLLIYQ---TLCYTHDELRE----------VDVGDFVLKP--------- 427

  Fly  1025 SFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEETPTLRVVSTPYTLQLMDSLPARELRLK 1089
                              |.|:  :.|....:|..:|.....|.......||||:....|    .
  Rat   428 ------------------CGLE--EFLQNKHALGSHEYIQHCRKFDINIRLQLMEQKAIR----S 468

  Fly  1090 DFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRP 1154
            |.|    ..||:....:..:...||||.    |.........|:|.||:
  Rat   469 DLA----RTVNDDQSPSTLNYLIHLQER----PVKQTISRQALSLLFDT---------------- 509

  Fly  1155 SCVNSDTPRFVSVLCLRSKYAGEISGLLSVLSEKDKAGLADRLVSDVWEAC-----AEKSD---- 1210
                               |..|:...|  |:|.|....|||:|..|...|     .|..:
  Rat   510 -------------------YHNEVDAFL--LAEGDFPLKADRVVQSVKAICNALAAVETPEITSA 553

  Fly  1211 --------ARHRGALWRATAYLIICSEISRKLLHAVASSQLELFT------ESAMETAVECWQWV 1261
                    :|.:..:.:..:.|.: .|...|::.|:.::.|:|..      .:..:|||..
  Rat   554 LNQLPPCPSRMQPKIQKDPSVLTV-RENREKVVEALTAAILDLVELYCSTFNADFQTAVPG---- 613

  Fly  1262 LTARQDL--ELCFIQEMVS-----------AWQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKP 1313
             :.:.||  |.|.....::           .|.|::|:    |.....::|      |.|.:..|
  Rat   614 -SRKHDLVQEACHFSGALAFTVYGTHRIPIIWATSYEE----FYLSCSLSH------GGKELCSP 667

  Fly  1314 IL-----IAPHLIWLQLLSEMVDTAKYCNR-DKVEMFCLLLHRCLPVL---KSSKQNRQ------ 1363
            :.     .:.:|..|.:..:.:......|| .:..:.|..|: .||:.   .||:.|:|
  Rat   668 LQTRRAHFSKYLFHLIIWDQQICFPVQVNRLPRETLLCATLY-ALPIPPPGSSSEANKQKRVPEA 731

  Fly  1364 ---VSTVGCRFK-LLQCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGPPTCPNQSREQLLED 1424
               |:|....|: :|.||..||.                         ..|.|..|.|..
  Rat   732 LGWVTTPLFNFRQVLTCGRKLLG-------------------------LWPATQENSSAR----- 766

  Fly  1425 IMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNP--ETASLISGGGLVNDYTRS 1487
                   |......:...|..:: |:..:...:..|.....:.:|  |..||
  Rat   767 -------WSAPNFHQPDSVILQI-DFPTSAFDIKFTSPPGDKFSPRYEFGSL------------- 810

  Fly  1488 MSASGNAVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILEL 1552
                                                |....::|        ||..:|.:|.
  Rat   811 ------------------------------------REEDQRKL--------KDITQKESLY--- 828

  Fly  1553 LAVELEFLITWYNPNSLPDLIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKN 1617
                                          |.:...|..:|.   :..:|:.
  Rat   829 ------------------------------WLSDADKKQLWE---KRYYCHT------------- 847

  Fly  1618 AEIIDEEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYIL-SWSPVTPIQALAYFSRQY 1681
                  |||.|    |:.:...| :.::.|.        ||:..:| .|:.:....||......:
  Rat   848 ------EVSSL----PLVLASAP-SWEWACL--------PDIYALLQQWTHMNHQDALGLLHATF 893

  Fly  1682 PSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNM 1744
            |...: .:.||:.:.|.....:|.|:|||||||:::..  ..:|.|:...:.....|.|...|.:
  Rat   894 PDQEV-RRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAISDLRVTHYFFWLL 957

  Fly  1745 QTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIR----SFA 1805
            :.::        ||.........|..:::.......:..:.|:......:..::.::|    |..
  Rat   958 KDSL--------KDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNTLAKLAQQVREATPSAR 1014

  Fly  1806 KGIERKNACLAALSRIK----VQGGCYLPSNPEAMV-----LDIDY--SSGTPMQSAAK--APYL 1857
            :||.|     |.|..::    :.|.|.||.:|..:|     .|..|  |:..|::.|.:  .|..
  Rat  1015 QGILR-----AGLEEVRQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLG 1074

  Fly  1858 ARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKN 1922
            ...||                                     |||.|||:|||||.||:|.|...
  Rat  1075 ENIRV-------------------------------------IFKCGDDLRQDMLTLQMIRIMSK 1102

  Fly  1923 IFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKSRDQL-------GRQTDSGLSEYFQ-HQYGDE 1979
            |:.|.|||:.:..:|..:|..|.|::|.:|||::..::       |...|..|:::.| |..|::
  Rat  1103 IWVQEGLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGED 1167

  Fly  1980 SSKEFQAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFG-FMFESSPGGNIGFE 2043
               |::.|..||:.|.|...:..|:|.|.||||.|||:...||:.||||| |:..:...|||..:
  Rat  1168 ---EYEKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRD 1229

  Fly  2044 --PDMKLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLP 2099
              |.:..:|...:|.||...|..|..|.:||.||:..:|.:....::|:.|||..|:|
  Rat  1230 RAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIP 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	35/177 (20%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	89/284 (31%)
Pik3c2b	XP_006249816.1	PI3K_rbd	363..465	CDD:395642	28/146 (19%)
		C2A_PI3K_class_II	621..793	CDD:175979	37/220 (17%)
		PI3Ka_II	812..980	CDD:238441	43/252 (17%)
		PI3Kc_C2_beta	986..1339	CDD:119421	102/347 (29%)
		PX_PI3K_C2_beta	1368..1476	CDD:132823
		C2B_PI3K_class_II	1504..1626	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810