Protein Alignment Pi4KIIIalpha and pik1

DIOPT Version :10

• Sequence 1: NP_001259191.1
• Gene: Pi4KIIIalpha / 31247
• FlyBaseID: FBgn0267350
• Length: 2154
• Species: Drosophila melanogaster
• Sequence 2: NP_594842.1
• Gene: pik1 / 2541887
• PomBaseID: SPAC22E12.16C
• Length: 851
• Species: Schizosaccharomyces pombe
• Alignment Length: 995
• Identity: 225/995 - (22%)
• Similarity: 371/995 - (37%)
• Gaps: 278/995 - (27%)

  Fly  1272 FIQEMVSAWQTTFEKRMGL--FAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAK 1334
            |..::..|:.:.:...:|:  |..|...|.|....|         ...|.||.|.|
pombe    20 FTSQLCVAYLSRYPNNIGIHHFLCEKLATFPYEEIE---------FFIPQLIHLVL--------- 66

  Fly  1335 YCNRDK----VEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQC-----GLSLLQGNTIPKSL 1390
              |:|.    :|.|         ::...:||.|.:.:  .|..||.     ||.       |.|.
pombe    67 --NKDSESVALEEF---------IISQCEQNTQCALI--TFWYLQAHMVDLGLQ-------PHSS 111

  Fly  1391 SRNILRERIYSNALDYFCGPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNA 1455
            ...|.: |:|:..                    .|::.:.....::|::|   .||    ::|.|
pombe   112 CFKICK-RLYNRI--------------------QILVFMSSSSLIQSQQK---ISE----NVTPA 148

  Fly  1456 SVSSTQML----------------------AVRNNPETASLISGGGLVNDYTRSMSASGN----- 1493
            .:.|..||                      |.|.:|:.:.:        |..|.:|....
pombe   149 LILSGIMLGGVCVPELLKKAGPIAIAQGRKAPRQDPDESDV--------DVLRRLSTEPRYSLDV 205

  Fly  1494 -AVGMGMGVAGGGSSSGWYNTIPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVEL 1557
             ...:...:....|........|..|.|.|.:|:.:..:..|:.....:|.::          |:
pombe   206 LRSSLNNSIVEQHSEVSLRLKAPELTRTHSYQSSATLSIDEQRRVLRSNYFQQ----------EI 260

  Fly  1558 EFLITWYNPNSLPD-----LIVPGEEQITEWRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKN 1617
            :||.      :|.|     :|||.:.:::..|            |.||...|.     ||..: |
pombe   261 QFLF------ALQDISIRLIIVPRQARLSSLR------------AELALLNNN-----LPADV-N 301

  Fly  1618 AEII---DEEVS-RLVCSDP--IAVCHIPEALKYLCTTKNLLQESPDLVYILSWSPVT-----PI 1671
            ..::   .:||| ::|..||  ..:.:..|.:.||...:.|..|       ||:.|.:     .:
pombe   302 IPLLRSYHKEVSHKIVRIDPKEATILNSAERVPYLIMVEVLSGE-------LSFEPQSKKNKAKV 359

  Fly  1672 QALAYFSRQYPS-------HPLT--AQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIK 1727
            |.:.....|...       .|.|  .......:|...:|.....:..|::.|..||:.....|
pombe   360 QKIVSHKNQRKRWFDLTDVDPYTNLQDSTDNDISESESEGGDLSMSPLIKGLVPDTLSLSKSF-- 422

  Fly  1728 NISRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKR--FYEREFDF 1790
                           :...|:.:.....|:|.::.....:.|.|   ..:||.||  .|..|
pombe   423 ---------------SSFGNVSLQVPSSHRDTDVVLLSGRHSDS---DGNGALKRSKIYASE--- 466

  Fly  1791 FGKITA-------------VSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDY 1842
               |||             ..|..|..|:....||:.:..:.|::.:    ..:.|....:.:|.
pombe   467 ---ITARMRAAATMLSQLDAEGSRRPKAETERIKNSIILDMQRLEEE----RLNEPSIYPVSVDI 524

  Fly  1843 SS------GTPMQSAAKA-----PYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESW 1896
            |.      |...|.|.:.     |..|.|:.......|...::....:.||             |
pombe   525 SCAEDLRFGKETQKAERKGDRDDPSAATFQEDWYAKKERIRKSSPYGHYPN-------------W 576

  Fly  1897 Q--AAIFKVGDDVRQDMLALQVITIFKNIFQQVGLDLFLFPYRVVATAPGCGVIECVPNAKS--- 1956
            .  :.|.|.|.|:||:..|.|:|..|:.::.:....:::...:::.|....|:||.:.||.|
pombe   577 DLVSVIVKTGADLRQETFACQLIYAFQRVWLECKEKVWVRRMKILVTGDNSGLIETITNAISVHS 641

  Fly  1957 -RDQLGRQTDSG--------------LSEYFQHQYGDESSKEFQAARANFVKSMAAYSLIGYLLQ 2006
             :..|.:|....              |.:||..|:||.:|..::.|:.||::|:.|||:|.||||
pombe   642 IKKNLTKQLREAELAQGKIAGKNVVTLKDYFIKQFGDPNSSRYRQAQTNFLQSLVAYSIISYLLQ 706

  Fly  2007 IKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFE-PDMKLTDEMVMIMGGKMDSPAFKWFCE 2070
            :|||||||::||.:||||||||||:..::| ||:||| ...|||.:.:.|:..:.|.     :..
pombe   707 LKDRHNGNVLIDSEGHIIHIDFGFLLTNTP-GNVGFESAPFKLTADYLEILDDRFDE-----YRS 765

  Fly  2071 LCVQAFLAVRPYQDAIVSLVSLMLDTG-LPCFRG--QTINLLKQRFVATKNNKEAAAHMLAVIRN 2132
            |...||.:||...|.|:.||.:|.:.. :||||.  .|...|.|||.....:||....:..:|:.
pombe   766 LMKAAFKSVRKNADQIILLVEVMQNNSTMPCFRAGENTSAQLLQRFQLQLGDKECDDFVDLLIQK 830

  Fly  2133 SYQNFRTRTYDMIQYYQNQI 2152
            :..:..||.||:.|...|.|
pombe   831 ANCSVWTRLYDLFQNITNGI 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4K_N	386..1571	CDD:437106	58/337 (17%)
		PI4Ka	1600..1775	CDD:238443	35/194 (18%)
		PI4Kc_III_alpha	1836..2153	CDD:270711	109/352 (31%)
pik1	NP_594842.1	TEL1	<1..851	CDD:227365	225/995 (23%)
		PI4Kc_III_beta	549..851	CDD:270712	103/321 (32%)