DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pi4KIIIalpha and Atr

DIOPT Version :9

Sequence 1:NP_001259191.1 Gene:Pi4KIIIalpha / 31247 FlyBaseID:FBgn0267350 Length:2154 Species:Drosophila melanogaster
Sequence 2:NP_063917.1 Gene:Atr / 245000 MGIID:108028 Length:2641 Species:Mus musculus


Alignment Length:2427 Identity:424/2427 - (17%)
Similarity:757/2427 - (31%) Gaps:879/2427 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 GVFCLDTRAQDAVIALGIYF--LEGGCQHE---GQI-----VPYLLRLAKCLP---KAVWID--- 95
            |:|.|.:..:.....:.::.  |:...|||   .|:     .|:|..|.|..|   |..:||   
Mouse   723 GMFYLSSSVEPCFEHMDLFSKNLKATSQHECSSSQVKASTCKPFLFLLTKNTPSPVKLAFIDNLH 787

  Fly    96 ----------DARSNKV-------------ERVRIPSAEKFSFCLNTLLSDIAAKCPDS--REEI 135
                      |.|..|.             :.|||..:....:.|.:|.|:      |.  :|..
Mouse   788 HLCKHLDFQEDEREVKAVLGTLLNLMEDPDKDVRIAFSGNIKYILESLNSE------DGFVKELF 846

  Fly   136 ILNQVETLSALANIVKSSRDSSSAPPPIILCKATVPLLFGLARSMGRYASNDPPLLCRIFPPELL 200
            :|...|..:. |.|.:::.           .|.|:.|..|   .:||.|..|           |:
Mouse   847 VLRMKEAYTH-AQIARNNE-----------LKDTLILTTG---DIGRAAKGD-----------LI 885

  Fly   201 PIQKGGGRDGTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGRQRCA 265
            |                             .|..|....::.:|     |....|:|.:.|...|
Mouse   886 P-----------------------------FALLHLLHCLLSKS-----ASVSGAAYTEIRALVA 916

  Fly   266 GGKPSKPSLHSYFSVPYDPRTHFFTRYGSSFNQFPNMRVCESPTKGGPRPLYRVPPFPIQHLQTI 330
             .|..|             ..:||::|.....||    :.||....   .:..:|..|.|     
Mouse   917 -AKSVK-------------LQNFFSQYKKPICQF----LVESLHSS---QMTALPSAPCQ----- 955

  Fly   331 FAVSKKLLTKDTLEHLDEQASDIFSLHQIKGYCYKSFSETLNLVLVTLLRELLQHQVDLPTPFTK 395
               |.::..:|...|.:...:.:..:..:..:      ..||..|...|:.||.   ||....:.
Mouse   956 ---SSEIRKQDVAHHREMALNTLSEIANVFDF------PDLNRFLTRTLQVLLP---DLAAKASP 1008

  Fly   396 DVQEFVKRLFLNGQTELQNKQQDQERERREENGIAVVNKYKVNVMANAACVDLLVWAIRDETVDV 460
            .....::.|         .||.:.  .|||    .::|.:|. :.::..|.     ..:||    
Mouse  1009 AASALIRTL---------GKQLNV--SRRE----ILINNFKY-IFSHLVCS-----CSKDE---- 1048

  Fly   461 DYNVPSLQNGLQFLLKKEADKLCGRLSQKLNLELSHKIVMD----HMPLLMVCLEGLGKLAHKFP 521
                  |:..|.: ||.|.:           :||...:..|    |..||:       ::...:.
Mouse  1049 ------LERALHY-LKNETE-----------IELGSLLRQDFQGLHNELLL-------RIGEHYQ 1088

  Fly   522 NIAGTSISYLRDFLVAPSPILGKLHDHAMQSLAQQKKEKELTPFKIAVQHSDSRTAVVIYGDNQK 586
            .:. ..:|.|..|..:..|..|               .:::|..::...:...:...::...|.:
Mouse  1089 QVF-NGLSILASFASSDDPYQG---------------PRDITSPELMADYLQPKLLGILAFFNMQ 1137

  Fly   587 PPGSGTGRSGHAAFESLRDAAIENLSIALRAAHTLDQFCVPALVANVSNRLFTAEKSGSESQG-- 649
            ...|..|              ||:..:||.:..:|.:...|..|::|..::.|..::|...:.  
Mouse  1138 LLSSSVG--------------IEDKKMALTSLMSLMKLMGPKHVSSVRVKMMTTLRTGLRFKDDF 1188

  Fly   650 --------ECHKSNLVSLNIIVMLGHVAVAL--------KDTSK-------TTQNILQFFIQRFC 691
                    :|....|....:..:|.||.|||        |:|:.       ..::.:|.|:....
Mouse  1189 PELCCRAWDCFVRCLDHAYLGPLLSHVIVALLPLIHMQPKETAAIFHYLIIENRDAVQDFLHEIY 1253

  Fly   692 KVPSEQNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQFHHVSDAVVN 756
            .:|...                |......:::.:.:.|.::..|..|.....:...|...|..::
Mouse  1254 FLPDHP----------------ELEKIKAVLQEYRKETSETTDLQTTLQLSMKAIQHENVDVRIH 1302

  Fly   757 ALGNIAANIQGDAEML-------ELLGKLLELFVQIGLDGERSYDNTPGAQKASSRA-------- 806
            ||.::...:..:.|.|       |.:..::...|.:.|         .|.|.|:|:|        
Mouse  1303 ALTSLKETLYKNQEKLIKYATDSETVEPVISQLVTVIL---------KGCQDANSQARLLCGECL 1358

  Fly   807 GNLGMLIPVIAVLVRRLPPIKNPRQRLHKLFKDF----------WAYCVVMGFTNARLWPADWYQ 861
            |.||.:.|      .||.......|.     |||          :||.::|..|.|.|..||   
Mouse  1359 GELGAIDP------GRLDFSTTETQG-----KDFTFVTGVEDLSFAYGLLMELTRAYLAYAD--- 1409

  Fly   862 GVQQIAAKSPLLISQTAHKSDMRELNYTLAIKSDSVNELRSQILVLLEHSSDNVATAINKLSFAQ 926
                                                 ..|:|         |:.|.||.:     
Mouse  1410 -------------------------------------NSRAQ---------DSAAYAIQE----- 1423

  Fly   927 CTYLLSVYWLEMLRVENADEPSLEPIMSYLCDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHD 991
               |||:|   ..|...::.|..:                 :|:       :..|..|.:|..|.
Mouse  1424 ---LLSIY---DCREMQSNGPGYQ-----------------LWK-------RFPEHVREILEPHL 1458

  Fly   992 EIREKVLESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWN----------------RRV 1040
            ..|.|..:....     ::.:.|||      |||.|.:.|..  |:                .::
Mouse  1459 NTRYKSSQKSTD-----WSGVTKPI------YLSKLGNNFAE--WSSSWAGYLITKVRDNLASKI 1510

  Fly  1041 LWCMLDILQ------------LLAYSLSLDPNEE------TPTLRVV--STPYTLQLMDSLPARE 1085
            ..|...:::            :|.|.| |..|:|      ...:.|:  ...:.:...||.    
Mouse  1511 FTCCSIMMKHDFKVTIYLLPHILVYVL-LGCNQEDQQEVYAEIMAVLKHDEQHAISTQDSA---- 1570

  Fly  1086 LRLKDFADRCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTM 1150
                  :|.||.......     |...||.::         |.|...||..:.:..:..: .|.:
Mouse  1571 ------SDLCQLSTQTVF-----SVLDHLTQW---------ARHKFQALNAEKLAQNKPK-GGKV 1614

  Fly  1151 SKRPSCVN----SDTPRF--------VSVLCLRSK-YAGEISGLLSVLSEKDK-----AGLADRL 1197
            :|..|.||    ....||        ::|...||| |...:....|.::||.:     .|...:|
Mouse  1615 NKILSNVNFEDYQSVTRFLDLIPQDTLAVASFRSKAYTRAVMHFESFITEKKQNIQKHLGFLQKL 1679

  Fly  1198 VSDVWE-------ACAEKSD-------ARHR--GALWRATAYLIICSEISRKL-------LHAVA 1239
            .:.:.|       :...|::       ..|.  |.|..|||    |.:.:.:|       .|.|.
Mouse  1680 YAAMHEPDGVAGVSAIRKAEPSLKEQILEHESIGLLRDATA----CYDRAIQLEPDQIIHYHGVV 1740

  Fly  1240 SSQLELFTESAMETAVE--------------------CW---QWVLTARQDLELCFIQEMVSA-- 1279
            .|.|.|...|.:.|.|.                    .|   ||.|          ::..::|  
Mouse  1741 KSMLGLGQLSTVITQVNGVHANRSEWTDELNTYRVEAAWKLSQWDL----------VENYLAADG 1795

  Fly  1280 WQTTFEKRMGLFAWETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRD----- 1339
            ..||:..|:|......:.......|:..|||.     |..::.|...|  .:...| .|.     
Mouse  1796 KSTTWSVRLGQLLLSAKKRDTTTFYDTLKLVR-----AEQIVPLSAAS--FERGSY-QRGYEFIV 1852

  Fly  1340 KVEMFCLLLHRCLPVLKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILRERIYSNAL 1404
            ::.|.|.|.|...|:.:.|..:      .|....|..|..|        .:::|..|        
Mouse  1853 RLHMLCELEHSLKPLFRKSPGD------SCNEDSLNWGARL--------EMTQNSYR-------- 1895

  Fly  1405 DYFCGPPTCPNQSREQLLEDIMILLKF-------------W-QTMRSEKK--HLVTS-----EVG 1448
                        ::|.:|.....||..             | |:.|..:|  |..|:     ..|
Mouse  1896 ------------AKEPILALRRALLSLNKRPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAG 1948

  Fly  1449 DYDLTNASVSSTQMLAVRNNPETASLISGGGLVNDYTRSMSASGNAVGMGMGVAGGGSSSGWYNT 1513
            :..|....|...:.|..:.:...|.::...|:...:..:.|.|.:.                 :.
Mouse  1949 ESRLAELYVERAKWLWSKGDVHQALIVLQKGVELCFPENKSPSESK-----------------HM 1996

  Fly  1514 IPHSTSTLSKRSNRSKRLQYQKDSYDKDYMKKRNLILELLAVELE---FLITWYNPNSLP----- 1570
            :.|..:||     ...|...:..:::.:.:.|:...:.|...|.|   |.:..|....:|     
Mouse  1997 LIHGRATL-----LVGRFMEETANFESNAVMKKYKDVTLFLPEWEDGHFYLAKYYDKLMPMVTDN 2056

  Fly  1571 ------DLI-----------VPGEEQITEWRNRPYKSTVWRDYARLAWCYNPA-----------L 1607
                  |||           ..|.:.|  :::.|...::|.|:...|:.:...           |
Mouse  2057 KMEKQGDLIRYIVLHFGRSLQYGNQFI--YQSMPRMLSLWLDFGAKAYEWEKGGRSDRLQMRNDL 2119

  Fly  1608 AVFLPQRIKNAEIIDEEVSRL-------VCSDPIA-VCHIPEALKYLCTTKNLLQESPDLVYILS 1664
            |       |...::.|..:||       ..|..|: :||                 |.|.|:::.
Mouse  2120 A-------KINSVLTEHTNRLAPYQFLTAFSQLISRICH-----------------SHDEVFVVL 2160

  Fly  1665 WSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSYPAESVLPYIPQLVQALRHDTMGYVVEFIKNI 1729
                  ::.:|.....||...:....|| :.||||                           ..:
Mouse  2161 ------MEIIAKVFLAYPQQAMWMMTAV-SKSSYP---------------------------MRV 2191

  Fly  1730 SRRSQIVAHQLIWNMQTNMYMDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKI 1794
            :|..:|:.                   |..::.::|::        |.|.|.|..::..:...  
Mouse  2192 NRCKEILT-------------------KAIHMKKSLEK--------FVGDATRLTDKLLELCN-- 2227

  Fly  1795 TAVSGEIRSFAKGIERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSS-GTPMQS-------- 1850
                       |.::..|:.|:..:..|:.         :.:|.|..:|. ..|:||        
Mouse  2228 -----------KSVDGSNSTLSMSTHFKML---------KRLVEDPTFSEILIPLQSVMIPTLPS 2272

  Fly  1851 -----AAKAPYLARFRVYRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIF--KVGDDVR 1908
                 |...|:...: .|..|..::    :|:.:  :.|:..|::|.....:..|.  |..||:|
Mouse  2273 VLGAHANHDPFPGHW-AYLAGFDDV----VEILS--SLQKPKKISLKGSDGKFYIMMCKPKDDLR 2330

  Fly  1909 QDMLALQVITIFKNIFQQVG----LDLFLFPYRVVATAPGCGVIECVPN---------------- 1953
            :|...::..::.....::..    .:|.:..|.|:.....||:||.|.|                
Mouse  2331 KDCRLMEFNSLINKSLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKIYKEKG 2395

  Fly  1954 ----AKSRDQLGRQTDSGLS-------------------EYFQHQYGDESSKEFQAARANFVKSM 1995
                .|...|......:.||                   |:|...:.|.:|  :.::|:.:.:|.
Mouse  2396 VYMTGKELRQCMLPKSAALSEKLKVFQELLLPRHPPVFHEWFLRTFPDPTS--WYSSRSAYCRST 2458

  Fly  1996 AAYSLIGYLLQIKDRHNGNIMIDK-DGHIIHIDFGFMFESSPGGNIGFEPDMKLTDEMVMIMGGK 2059
            |..|::||:|.:.|||..||:.|. .|..:|:||..:|.......:......:||..||..||..
Mouse  2459 AVMSMVGYILGLGDRHGENILFDSFTGECVHVDFNCLFNKGETFEVPEIVPFRLTHNMVNGMGPM 2523

  Fly  2060 MDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLPCFRGQTINLLKQRFVATKN------ 2118
            .....|:..||:.::   .:|..::.::|::...|...|.    :....:|....|..|      
Mouse  2524 GTEGLFRRACEVTLR---LMRDQREPLMSVLKTFLHDPLV----EWSKPVKGHSKAPLNETGEVV 2581

  Fly  2119 NKEAAAHMLAVIRNSYQNFRTR 2140
            |::|..|:|.:.:......:||
Mouse  2582 NEKAKTHVLDIEQRLQGVIKTR 2603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pi4KIIIalphaNP_001259191.1 PI4Ka 1600..1775 CDD:238443 27/193 (14%)
PI4Kc_III_alpha 1836..2153 CDD:270711 77/371 (21%)
AtrNP_063917.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 423..447
HEAT repeat 690..720 CDD:293787
HEAT repeat 729..788 CDD:293787 13/58 (22%)
HEAT 1 799..835 6/35 (17%)
HEAT repeat 802..837 CDD:293787 6/34 (18%)
UME 1119..1225 CDD:214825 21/119 (18%)
HEAT 2 1329..1365 10/44 (23%)
NR_LBD 1529..>1607 CDD:299703 19/102 (19%)
FAT 1771..2092 CDD:280429 65/396 (16%)
TEL1 <2123..2641 CDD:227365 108/597 (18%)
PIKKc_ATR 2290..2564 CDD:270625 59/288 (20%)
FATC 2610..2641 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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