DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and Pik3c2b

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	NP_001092746.2	Gene:	Pik3c2b / 240752	MGIID:	2685045	Length:	1632	Species:	Mus musculus

Alignment Length:	1288	Identity:	263/1288 - (20%)
Similarity:	435/1288 - (33%)	Gaps:	415/1288 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1057 LDPNEETPTLRVVSTPYTLQLMDS--------LPARELRLKDFAD-RCQGI---------VNEAM 1103
            |.|.:.:|:...:|.|..:....|        |.|::....:..| |.||.         :|:|:
Mouse   170 LPPRKGSPSPSKISQPNDINSFSSAEQPPDKLLVAQDPEEGELPDGRGQGHTLGSVDYDGINDAI 234

  Fly  1104 KWAPRSTRSHLQEYPNQIPTPVLAHHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDT------- 1161
                  ||.:|:.                  .:||.:||.|.......:.|...|.||
Mouse   235 ------TRLNLKS------------------TYDSEISSDATRGWKEGRGPLDFNKDTSGKPVAR 275

  Fly  1162 ----PRFVSVLCLRSKYAG----------EISG---------------LLSVLSEKDKAGLADRL 1197
                |..|......|:||.          .||.               |..|..|:|:...|...
Mouse   276 SKTMPPQVPPRTYTSRYANRKNATPGNNRRISAAPVGSRPHTVANGHELFEVSEERDEEVAAFCH 340

  Fly  1198 VSDVWEACAEKSDARHRGALWRATA-------------YLIICSEISRKLLHAV-ASSQLELFTE 1248
            :.|:....::..|....|.:|....             ..::|..:...|.... .||.::|...
Mouse   341 MLDILRTGSDIQDYSLTGCVWSTVTPSPEHLGDEVNLKVTVLCDSLREPLTFTCNCSSTVDLLIH 405

  Fly  1249 SAMETAVECWQWVLTARQD-----LELCFIQEMVSAWQTTFEKRMGLFAWETEVTHPLAAYEGCK 1308
            ..:     |:........|     |:.|.::|.:                  :..|.|.::|..:
Mouse   406 QTL-----CYTHDELREVDVGDFVLKPCGLEEFL------------------QNKHALGSHEYIQ 447

  Fly  1309 LVSKPILIAPHLIWLQLLSEMV---DTAKYCNRDK-VEMFCLLLHRCLPVLKSSKQNRQVSTVGC 1369
            ...|..:    .|.|||:.:..   |.|:..|.|: ......|:|         .|.|.|.....
Mouse   448 YCRKFDI----SIRLQLMEQKAIRSDLARTVNDDQSPSTLNYLIH---------LQERPVKQTIS 499

  Fly  1370 R--FKLL------QCGLSLLQGNTIPKSLSRNILRERIYSNALDYFCGP---------PTCPNQS 1417
            |  ..||      :....||.....|....|.:...:...|||.....|         |.||::.
Mouse   500 RQALSLLFDTYHNEVDAFLLADGDFPLKADRVVQSVKAICNALAAVETPEITSALNQLPPCPSRM 564

  Fly  1418 REQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLTNASVSSTQMLAVRNNPETASLISG----- 1477
            :.::.:|..:|     ::|..::.:|.:      ||.|.:...::.....|.:..:.:.|
Mouse   565 QPKIQKDPSVL-----SVRENREKVVEA------LTAAILDLVELYCSTFNADFQTAVPGSRKHD 618

  Fly  1478 ---------GGLV-----------------NDYTRSMSASGNAVGMGMGVAGGGSSSG------- 1509
                     |.|.                 .|:..|.|.|          .||.....
Mouse   619 LVQEACHFPGALAFTVYGTHRIPIIWATSYEDFYLSCSLS----------HGGKELCSPLQTRRA 673

  Fly  1510 -----------W---------YNTIPHST---STL----------SKRSNRSKRLQYQKDSYDKD 1541
                       |         .|.:|..|   :||          |..:|:.||:..........
Mouse   674 HFSKYLFHLIIWDQQICFPVQVNRLPRETLLCATLYALPVPPPGGSSEANKQKRVPEALGWVTTP 738

  Fly  1542 YMKKRNLIL---ELL----AVELEFLITWYNPN-SLPDLIV-----------------PGE---- 1577
            ....|.::.   :||    |.:......|..|| ..||.::                 ||:
Mouse   739 LFNFRQVLTCGRKLLGLWPATQENSGARWSAPNFHQPDSVILQIDFPSSAFDIKFTSPPGDKFSP 803

  Fly  1578 ---------------EQITE-----WRNRPYKSTVWRDYARLAWCYNPALAVFLPQRIKNAEIID 1622
                           :.||:     |.....|..:|.   :..:|:.
Mouse   804 RYEFGSLREEDQRKLKDITQKESLYWLTDADKKQLWE---KRYYCHT------------------ 847

  Fly  1623 EEVSRLVCSDPIAVCHIPEALKYLCTTKNLLQESPDLVYIL-SWSPVTPIQALAYFSRQYPSHPL 1686
             |||.|    |:.:...| :.::.|.        ||:..:| .|:.:....||......:|...:
Mouse   848 -EVSSL----PLVLASAP-SWEWACL--------PDIYALLQQWTHMNHQDALGLLHATFPDQEV 898

  Fly  1687 TAQYAVKTLSSYPAESVLPYIPQLVQALRHDTM--GYVVEFIKNISRRSQIVAHQLIWNMQTNMY 1749
             .:.||:.:.|.....:|.|:|||||||:::..  ..:|.|:...:.....|.|...|.::.::
Mouse   899 -RRMAVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAISDLRVTHYFFWLLKDSL- 961

  Fly  1750 MDEDQQHKDPNLYEALDQLSQSIIASFSGAAKRFYEREFDFFGKITAVSGEIR----SFAKGIER 1810
                   ||.........|..:::.......:..:.|:......:..::.::|    |..:||.|
Mouse   962 -------KDSQFSIRYQYLLAALLCCCGKGLREEFNRQCWLVNTLAKLAQQVREATPSARQGILR 1019

  Fly  1811 KNACLAALSRIK----VQGGCYLPSNPEAMV-----LDIDY--SSGTPMQSAAK--APYLARFRV 1862
                 ..|..:|    :.|.|.||.:|..:|     .|..|  |:..|::.|.:  .|.....||
Mouse  1020 -----VGLEEVKQFFALNGSCRLPLSPSLLVKGIVPRDCSYFNSNAVPLKLAFQNVDPLGENIRV 1079

  Fly  1863 YRCGITELETRAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQVITIFKNIFQQV 1927
                                                 |||.|||:|||||.||:|.|...|:.|.
Mouse  1080 -------------------------------------IFKCGDDLRQDMLTLQMIRIMSKIWVQE 1107

  Fly  1928 GLDLFLFPYRVVATAPGCGVIECVPNAKSRDQL-------GRQTDSGLSEYFQ-HQYGDESSKEF 1984
            |||:.:..:|..:|..|.|::|.:|||::..::       |...|..|:::.| |..|::   |:
Mouse  1108 GLDMRMVIFRCFSTGRGKGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNPGED---EY 1169

  Fly  1985 QAARANFVKSMAAYSLIGYLLQIKDRHNGNIMIDKDGHIIHIDFG-FMFESSPGGNIGFE--PDM 2046
            :.|..||:.|.|...:..|:|.|.||||.|||:...||:.||||| |:..:...|||..:  |.:
Mouse  1170 EKAVENFIYSCAGCCVATYILGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRDRAPFV 1234

  Fly  2047 KLTDEMVMIMGGKMDSPAFKWFCELCVQAFLAVRPYQDAIVSLVSLMLDTGLP 2099
            ..:|...:|.||...|..|..|.:||.||:..:|.:....::|:.|||..|:|
Mouse  1235 FTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLSCGIP 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	35/177 (20%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	89/284 (31%)
Pik3c2b	NP_001092746.2	PI3K_rbd	363..465	CDD:366310	18/128 (14%)
		C2A_PI3K_class_II	621..793	CDD:175979	27/181 (15%)
		PI3Ka_II	812..980	CDD:238441	40/211 (19%)
		PI3Kc_C2_beta	986..1339	CDD:119421	102/347 (29%)
		PX_PI3K_C2_beta	1368..1476	CDD:132823
		C2B_PI3K_class_II	1504..1626	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810