DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pi4KIIIalpha and SMG1

DIOPT Version :9

Sequence 1:	NP_001259191.1	Gene:	Pi4KIIIalpha / 31247	FlyBaseID:	FBgn0267350	Length:	2154	Species:	Drosophila melanogaster
Sequence 2:	XP_005255239.1	Gene:	SMG1 / 23049	HGNCID:	30045	Length:	3689	Species:	Homo sapiens

Alignment Length:	2385	Identity:	429/2385 - (17%)
Similarity:	750/2385 - (31%)	Gaps:	807/2385 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MTASDKYTYQRTVLCLARVLAGIQPTPWDKVQTLFRYCPQENAAGVFCLDTRAQDAVIALGIYFL 67
            :||:::..:...||..|....|:.....|...|:  :|                |.||..|:..|
Human   440 VTAANQVFFSEAVLTAANECVGVLLGSLDPSMTI--HC----------------DMVITYGLDQL 486

  Fly    68 EGGCQHEGQIVPYLLRLAKCLPKAVWIDDAR--SNKVERVRIPSAE------------------- 111
            | .||..|  ..|::.:...|...|...:.:  |:.||::.|||::
Human   487 E-NCQTCG--TDYIISVLNLLTLIVEQINTKLPSSFVEKLFIPSSKLLFLRYHKEKEVVAVAHAV 548

  Fly   112 ----------------------KFSFCLNTLLS--DIAAKCPDSREEIILNQVET---------- 142
                                  :.:..||.||.  .:...|.:.:.|...|.|..
Human   549 YQAVLSLKNIPVLETAYKLILGEMTCALNNLLHSLQLPEACSEIKHEAFKNHVFNVDNAKFVVIF 613

  Fly   143 -LSALANIVKSSRDSSSAPPPIILCKATVPLLFGLARSMGRYASNDPPLLCRIFP----PELLPI 202
             ||||..|       .:|...:|...|..|.:|.|.........:|   |...||    ..|..:
Human   614 DLSALTTI-------GNAKNSLIGMWALSPTVFALLSKNLMIVHSD---LAVHFPAIQYAVLYTL 668

  Fly   203 QKGGGRD----GTGSSSSASGTCGGSFSSSERLAATHHFRPIIPRSMSGSLAQAQNASYDDGR-- 261
            .....|.    .:..|||:.....|:..|:...|...||..|:  ::.|.|.:..|.:.|..:
Human   669 YSHCTRHDHFISSSLSSSSPSLFDGAVISTVTTATKKHFSIIL--NLLGILLKKDNLNQDTRKLL 731

  Fly   262 -----QRCAGGKPSKPSLHSYFSVPYDPRTHFFTRYGSSFNQF----------PNMRVCESPTKG 311
                 :.....|.|: :....||:|             ||::|          .::.:|
Human   732 MTWALEAAVLMKKSE-TYAPLFSLP-------------SFHKFCKGLLANTLVEDVNIC------ 776

  Fly   312 GPRPLYRVPPFPIQHLQTIFAVSKKLLTKDTLEHLDEQASDI---------FSLHQIKGYCYKSF 367
                        :|...::.|:|..|     .:.|.::..|:         ..:.|..|...||.
Human   777 ------------LQACSSLHALSSSL-----PDDLLQRCVDVCRVQLVHSGTRIRQAFGKLLKSI 824

  Fly   368 SETLNLVLV----TLLRE----LLQHQVDLPTPFTKDVQEF--VKRLFLNGQTELQNKQQDQER- 421
              .|::||.    |.::|    |..|....|:. |...|:|  |....|.|.:....|....||
Human   825 --PLDVVLSNNNHTEIQEISLALRSHMSKAPSN-TFHPQDFSDVISFILYGNSHRTGKDNWLERL 886

  Fly   422 -------ERREENGIAVVNKYKVNVMANAACVDLLVWAIRDETVDVDYNVPSLQNGLQFLLKKEA 479
                   ::|:::.|. .|..|.:.:       |..|||.:              ..||.:
Human   887 FYSCQRLDKRDQSTIP-RNLLKTDAV-------LWQWAIWE--------------AAQFTV---- 925

  Fly   480 DKLCGRLSQKLNLELSHKIVMDHMPLLMVCLEGLGKLAHKFPNIAGTSISYLRDFLVAPSPILGK 544
                  || ||...                   ||:....|..|.|               |:..
Human   926 ------LS-KLRTP-------------------LGRAQDTFQTIEG---------------IIRS 949

  Fly   545 LHDHAMQSLAQQKKEKELTPFKIAVQ---HSDSRTAVVI---YGDNQKPPGSGTGRSGHAAFESL 603
            |..|.:      ..:::::.:..|..   |.:::..:|:   |.:|.:       :..:.|:|..
Human   950 LAAHTL------NPDQDVSQWTTADNDEGHGNNQLRLVLLLQYLENLE-------KLMYNAYEGC 1001

  Fly   604 RDAAIENLSIALRAAHTLDQFC-------------------VPALVANVSNRLFTAEKSGSESQG 649
            .:|......:.....:|..|.|                   .||:.......|.|..|:.|.|||
Human  1002 ANALTSPPKVIRTFFYTNRQTCQDWLTRIRLSIMRVGLLAGQPAVTVRHGFDLLTEMKTTSLSQG 1066

  Fly   650 ECHKSNLVSLNIIVMLGHV----------AVALKDTSKTTQNIL------QFFIQRFCK--VPSE 696
                 |.:.:.|::::..:          .:|:..:|...:|:|      |....||.|  |..:
Human  1067 -----NELEVTIMMVVEALCELHCPEAIQGIAVWSSSIVGKNLLWINSVAQQAEGRFEKASVEYQ 1126

  Fly   697 QNALIVDQLGCMIISQCETHVFDEIMKMFSRVTVQSASLAYTSDPEHRKQF----HHVSDAVVNA 757
            ::...:..:.|.|.|      ||:.:...:.....|||..::.:.|.||..    ...|..|:|.
Human  1127 EHLCAMTGVDCCISS------FDKSVLTLANAGRNSASPKHSLNGESRKTVLSKPTDSSPEVINY 1185

  Fly   758 LGNIAANIQGDAEMLELLGKLLELFVQIG-LDGERSYDNTPGAQKASSRAGNLGMLIPVIAVLVR 821
            |||                |..|.::.|. ....:.:.|.....|.|:.:.:|
Human  1186 LGN----------------KACECYISIADWAAVQEWQNAIHDLKKSTSSTSL------------ 1222

  Fly   822 RLPPIKNPRQRLHKLFKDFWAYCVVMGFTNARLWPADWYQGVQQI----AAKSPLLISQTAHKSD 882
                         .|..||.....:..|.:.:     :.:..:|:    .....||...:..|.|
Human  1223 -------------NLKADFNYIKSLSSFESGK-----FVECTEQLELLPGENINLLAGGSKEKID 1269

  Fly   883 MRELNYTLAIKSDSVNELRSQILVLLEHSSDNVATAINKLSFAQ---------CTYLLSVYWLEM 938
            |::|...:.  |....||:..|.|.|..||..:|||:|.:...|         ..||.....:.:
Human  1270 MKKLLPNML--SPDPRELQKSIEVQLLRSSVCLATALNPIEQDQKWQSITENVVKYLKQTSRIAI 1332

  Fly   939 --LRVENADEPSLEPIMSYL---CDTALQRDKTGIWQCVKCVADQVFEKFRNVLYAHDEIREKVL 998
              ||:.........|::|.|   |.:||:...:.......|:.....|..|: ...|| :|..:
Human  1333 GPLRLSTLTVSQSLPVLSTLQLYCSSALENTVSNRLSTEDCLIPLFSEALRS-CKQHD-VRPWM- 1394

  Fly   999 ESQATLLLVYFNHIHKPIQMVADQYLSFLVDRFPHLLWNRRVLWCMLDILQLLAYSLSLDPNEET 1063
              ||....:|.|.:.:.|:.......|.|::                  |.|.|...:......:
Human  1395 --QALRYTMYQNQLLEKIKEQTVPIRSHLME------------------LGLTAAKFARKRGNVS 1439

  Fly  1064 PTLRVVSTPYTLQLMDSLPARELRLKDFAD-RCQGIVNEAMKWAPRSTRSHLQEYPNQIPTPVLA 1127
            ...|:::....:||..:..|::| ::.|.. ..||.|:|  ||.|.
Human  1440 LATRLLAQCSEVQLGKTTTAQDL-VQHFKKLSTQGQVDE--KWGPE------------------- 1482

  Fly  1128 HHSGLALAFDSVVSSSAQHTGTMSKRPSCVNSDTPRFVSVLC--LRSKYA--------------- 1175
                |.:....::.::.|.|..|....||..|        .|  ::::||
Human  1483 ----LDIEKTKLLYTAGQSTHAMEMLSSCAIS--------FCKSVKAEYAVAKSILTLAKWIQAE 1535

  Fly  1176 -GEISGLLSVL----SEKDKAGLADRLVSDVWEACAEKSDARHRGALWRATAYLIICSEISRKLL 1235
             .||||.|..:    .:::..||                                  |.:|:.:|
Human  1536 WKEISGQLKQVYRAQHQQNFTGL----------------------------------STLSKNIL 1566

  Fly  1236 --------HAVASSQLELFTESAMETAVECWQWVLTARQDLELCFIQEMVSAWQTTFEKRMGLFA 1292
                    :.:......:.:||.:...|....::|.....|......|:..:|...   ....:.
Human  1567 TLIELPSVNTMEEEYPRIESESTVHIGVGEPDFILGQLYHLSSVQAPEVAKSWAAL---ASWAYR 1628

  Fly  1293 WETEVTHPLAAYEGCKLVSKPILIAPHLIWLQLLSEMVDTAKYCNRDKVEMFCLLLHR-CLPV-- 1354
            |..:|....:..||.:|:.:......:|        :.||  ....:|..::.:|... |.|.
Human  1629 WGRKVVDNASQGEGVRLLPREKSEVQNL--------LPDT--ITEEEKERIYGILGQAVCRPAGI 1683

  Fly  1355 --------LKSSKQNRQVSTVGCRFKLLQCGLSLLQGNTIPKSLSRNILR------ERIYS---- 1401
                    :..|:.|.:...|...::.|......|  :.:.:|.:..:::      :||:|
Human  1684 QDEDITLQITESEDNEEDDMVDVIWRQLISSCPWL--SELDESATEGVIKVWRKVVDRIFSLYKL 1746

  Fly  1402 NALDYFC-------------GPPTCPNQSREQLLEDIMILLKFWQTMRSEKKHLVTSEVGDYDLT 1453
            :...||.             ..|......|.:...|.||::...:.:|...||  ..|:..|...
Human  1747 SCSAYFTFLKLNAGQIPLDEDDPRLHLSHRVEQSTDDMIVMATLRLLRLLVKH--AGELRQYLEH 1809

  Fly  1454 NASVSST--------QMLAVRNNPE-----------------TASLISGGGLVNDYTRSMS---- 1489
            ....:.|        |:.:..|:||                 :..||....:|.  |.|:|
Human  1810 GLETTPTAPWRGIIPQLFSRLNHPEVYVRQSICNLLCRVAQDSPHLILYPAIVG--TISLSSESQ 1872

  Fly  1490 ASGN----AVGMGMG-VAG---------GGSSSGWYNTIPHSTSTLSK---RSNRSKRLQYQKDS 1537
            ||||    |:...:| :.|         |||        |.::...:|   :|..::.....:|.
Human  1873 ASGNKFSTAIPTLLGNIQGEELLVSECEGGS--------PPASQDSNKDEPKSGLNEDQAMMQDC 1929

  Fly  1538 YDK--DYMKKRN----LILELLAVELEFLITWYNPNSLPDL------IVPGEEQITEWRNRPYKS 1590
            |.|  |.:...|    |.:::|..||..:...::...|..|      ::...:|:.:...|...:
Human  1930 YSKIVDKLSSANPTMVLQVQMLVAELRRVTVLWDELWLGVLLQQHMYVLRRIQQLEDEVKRVQNN 1994

  Fly  1591 TVWRDYARLAWCYNPALAVFLPQRIKNAEIIDEEVSRLVCSDPIAVCH-----------IPEALK 1644
            ...|...::|.......|:..|      .:...|..|.:.:.|....|           |..||:
Human  1995 NTLRKEEKIAIMREKHTALMKP------IVFALEHVRSITAAPAETPHEKWFQDNYGDAIENALE 2053

  Fly  1645 YLCTTKNLLQESPDLVYILSWSPVTPIQALAYFSRQYPSHPLTAQYAVKTLSSY--PAESVLPYI 1707
            .|.|..|..:...      ||.|...|.             |:.|...:..:||  ..|.:.|::
Human  2054 KLKTPLNPAKPGS------SWIPFKEIM-------------LSLQQRAQKRASYILRLEEISPWL 2099

  Fly  1708 PQLVQALRHDTMGYVVEFIKNISRRSQIVAHQL-----IWNMQTN----MYMDEDQQHKDPNLYE 1763
            ..:...        .:.....:|.|..:..|.:     |...:|.    :::..|.: ..|.|::
Human  2100 AAMTNT--------EIALPGEVSARDTVTIHSVGGTITILPTKTKPKKLLFLGSDGK-SYPYLFK 2155

  Fly  1764 ALDQLS--------QSIIASFSGA-----AKRFYEREFDF------FGKITAVSGEIRSFA--KG 1807
            .|:.|.        .||:.:....     ..||:.|.:..      .|.|..|.|....|.  |.
Human  2156 GLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKR 2220

  Fly  1808 IERKNACLAALSRIKVQGGCYLPSNPEAMVLDIDYSSGTPMQSAAKAPYLARFRVYRCGITELET 1872
            .:::.|.|.|.   |.|.....|.||                                ||.
Human  2221 WQQREAALQAQ---KAQDSYQTPQNP--------------------------------GIV---- 2246

  Fly  1873 RAMEVSNNPNSQEDAKMTLGVESWQAAIFKVGDDVRQDMLALQV------ITIFKNIFQQVGLDL 1931
                    |...|            ....|:|..::...|:|.|      :.:.|.:.:::
Human  2247 --------PRPSE------------LYYSKIGPALKTVGLSLDVSRRDWPLHVMKAVLEEL---- 2287

  Fly  1932 FLFPYRVVATAPGCGVIECVPNAKSRDQLGRQTDSGLSEYFQHQYGDESSKEFQAARANFVKSMA 1996
                  :.||.|.....|...:..:.|:..|.|.|                        :.:|.|
Human  2288 ------MEATPPNLLAKELWSSCTTPDEWWRVTQS------------------------YARSTA 2322

  Fly  1997 AYSLIGYLLQIKDRHNGNIMID-KDGHIIHIDFGFMFESSPGGNI 2040
            ..|::||::.:.|||..|::|| ..|.::|||:...||.   |||
Human  2323 VMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYNVCFEK---GNI 2364

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pi4KIIIalpha	NP_001259191.1	PI4Ka	1600..1775	CDD:238443	35/204 (17%)
Pi4KIIIalpha	NP_001259191.1	PI4Kc_III_alpha	1836..2153	CDD:270711	38/212 (18%)
SMG1	XP_005255239.1	SMG1	631..1242	CDD:292413	140/792 (18%)
		PIKKc_SMG1	2121..2454	CDD:270714	65/341 (19%)
		FATC	3659..3688	CDD:280430
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900